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Impaired cyclic AMP generation in outer medullary tubules of gentamicin-treated rats.

Abstract：

:We have examined the effects of chronic gentamicin treatment on arginine8-vasopressin (AVP)-dependent cyclic AMP (cAMP) metabolism in rat medullary collecting tubules (oMCT) and medullary thick ascending limbs of Henle's loop (mTALH). Gentamicin attenuated AVP-stimulated cAMP accumulation to a greater extent in the mTALH (delta -51%) than in the oMCT (delta -25%). The mechanism of attenuation differed between segments, and could not be attributed to either direct inhibition of adenylate cyclase activity nor direct potentiation of cAMP-phosphodiesterase activity. These data suggest that the gentamicin-induced decrease in renal concentrating ability may be due at least in part to reduced AVP-dependent cAMP accumulation in the oMCT and mTALH.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Kidwell D,Subramaniam S,Ott C,Jackson B

doi

10.1016/0014-2999(90)94186-2

subject

Has Abstract

pub_date

1990-12-04 00:00:00

pages

489-92

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(90)94186-2

journal_volume

191

pub_type

杂志文章

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