Potentiation by neuropeptide Y of 5HT2A receptor-mediated contraction in porcine coronary artery.

abstract：:Brain microvessel endothelial cell monolayers have been shown to be a suitable blood-brain barrier in vitro system to study adrenergic regulation of permeability. We tested adrenergic drugs on bovine brain microvessel endothelial cell monolayer permeability to a biomembrane impermeant molecule, sodium fluorescein. End...

journal_title：European journal of pharmacology

authors： Borges N,Shi F,Azevedo I,Audus KL

更新日期：1994-10-14 00:00:00

abstract：:The effect of omeprazole, a proton pump inhibitor, on the forward passage of the crop contents of chicks receiving 20% medium chain or long chain triacylglycerol was studied. Medium chain triacylglycerol significantly delayed the crop emptying of chicks compared with long chain triacylglycerol. Omeprazole also signifi...

journal_title：European journal of pharmacology

authors： Mabayo RT,Furuse M,Okumura J

更新日期：1995-01-24 00:00:00

abstract：:This study evaluated the possible involvement of 5-HT(2B) receptors in long-lasting hypotension to 5-hydroxytryptamine (5-HT), which is predominantly mediated by 5-HT7 receptors, in anaesthetised vagosympathectomized rats. Intravenous injections of 5-HT and 5-carboxamidotryptamine (5-CT) elicited a dose-dependent hypo...

journal_title：European journal of pharmacology

authors： Centurión D,Glusa E,Sánchez-López A,Valdivia LF,Saxena PR,Villalón CM

更新日期：2004-10-19 00:00:00

abstract：:cRNA encoding the human IsK protein was injected into Xenopus oocytes and the expressed channels were investigated using the two-microelectrode voltage-clamp method. The novel class III antiarrhythmic NE-10064 (1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]-amino]-3- [4-(4-methyl-1-piperazinyl)-butyl]-2,4-imidazolidined...

journal_title：European journal of pharmacology

authors： Busch AE,Herzer T,Takumi T,Krippeit-Drews P,Waldegger S,Lang F

更新日期：1994-10-13 00:00:00

abstract：:The tolerance to analgesia and dependence liability of dihydroetorphine following topical application were investigated in hairless rats with and without formalin-induced inflammation. The analgesic effect of dihydroetorphine (s.c.) was 4600- to 7200-fold more potent than that of morphine. In non-inflamed rats, the an...

journal_title：European journal of pharmacology

authors： Ohmori S,Fang L,Kawase M,Saito S,Morimoto Y

更新日期：2001-07-06 00:00:00

abstract：:The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three agents shifted calcium dose-force relationships parallel and to the right. D600 acted as a competitive antagonist of calcium, as a plot of log...

journal_title：European journal of pharmacology

authors： Bristow MR,Green RD

更新日期：1977-10-01 00:00:00

abstract：:The mechanisms underlying myocardial dysfunction in sepsis remain poorly understood. The theoretical benefits of nitric oxide synthase (NOS) inhibition in reversing the haemodynamic changes that characterise septic shock have not been supported by clinical trials, some of which have demonstrated detrimental myocardial...

journal_title：European journal of pharmacology

authors： Price S,Evans TW,Mitchell JA

更新日期：2002-08-09 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-boun...

journal_title：European journal of pharmacology

authors： Luly P,Baldini P,Cocco C,Incerpi S,Tria E

更新日期：1977-11-15 00:00:00

abstract：:We recently observed that the 5-hydroxytryptamine (5-HT)(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)-cycloh exanecarboxamide (WAY 100635) enhanced antipsychotic-induced catalepsy, which we hypothesized to be due to a blockade of tonic 5-HT(1A) receptor activation. Here, we ex...

journal_title：European journal of pharmacology

authors： Prinssen EP,Koek W,Kleven MS

更新日期：2000-04-28 00:00:00

abstract：:The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery...

journal_title：European journal of pharmacology

authors： Shimazawa M,Takiguchi Y,Umemura K,Kondo K,Nakashima M

更新日期：1997-06-11 00:00:00

abstract：:In the presence of 3 x 10(-6) M captopril, 5 x 10(-7) M des-Asp-Angiotensin I was found to inhibit the electrically (1 and 2 Hz) induced contraction of the rabbit pulmonary artery but had no significant effect on the noradrenaline-stimulated contraction. 2.8 x 10(-6) M indomethacin and 10(-6) M losartan but not 10(-6)...

journal_title：European journal of pharmacology

authors： Sim MK,Soh KS

更新日期：1995-09-15 00:00:00

abstract：:Edaravone is a potent scavenger of hydroxyl radicals and attenuates oxidative damage-related neurodegenerative diseases. Previous studies suggest that oxidative stress plays a key role in the pathogenesis of diabetes. The present study examined the effect of edaravone on diabetes in multiple low-dose streptozotocin-tr...

journal_title：European journal of pharmacology

authors： Fukudome D,Matsuda M,Kawasaki T,Ago Y,Matsuda T

更新日期：2008-03-31 00:00:00

abstract：:We aimed to develop an anovulation model, using sulpiride-induced hyperprolactinemia in common marmosets. The serum prolactin level gradually increased during the twice-daily administration of sulpiride and reached a plateau after 4 days. Sulpiride produced as big a response at 10 mg kg(-1) as at 50 mg kg(-1). In this...

journal_title：European journal of pharmacology

authors： Moro M,Inada Y,Kojima M,Miyata H,Komatsu H,Torii R

更新日期：1999-02-26 00:00:00

abstract：:This study compares the antimitogenic effects of iloprost and prostaglandin E1 on platelet-derived growth factor-BB stimulated DNA synthesis ([3H]thymidine incorporation) in bovine coronary artery smooth muscle cells. When added 20-24 h after stimulation with platelet-derived growth factor-BB (20 ng/ml), both iloprost...

journal_title：European journal of pharmacology

authors： Zucker TP,Bönisch D,Hasse A,Grosser T,Weber AA,Schrör K

更新日期：1998-03-19 00:00:00

abstract：:Neurotrophic and neuroprotective properties of Hsp70 were studied in olfactory cortex slices of hypertensive rats under normal conditions and under influence of autologous blood (blood clot). Under normal conditions, synaptic response in slices depended on Hsp70 amount in medium. Incubation of slices with Hsp70 showed...

journal_title：European journal of pharmacology

authors： Mokrushin AA,Pavlinova LI

更新日期：2012-02-29 00:00:00

abstract：:Venlafaxine is a dual serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake inhibitor which has been claimed to have an onset of antidepressant action which is faster than for other comparable drugs. The effects of venlafaxine on brain 5-HT levels in vivo have not yet been examined. Acute administration of ve...

journal_title：European journal of pharmacology

authors： Gur E,Dremencov E,Lerer B,Newman ME

更新日期：1999-05-07 00:00:00

abstract：:Mice, subjected footshock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects were partially antagonized by pretreatment with naloxone at high doses. The magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in mo...

journal_title：European journal of pharmacology

authors： Nabeshima T,Yamada K,Kameyama T

更新日期：1983-09-02 00:00:00

abstract：:The effects of conditioned fear on gross activity, heart rate, PQ interval, noradrenaline and adrenaline were studied in freely moving rats. Subcutaneous (s.c.) injections of atropine methyl nitrate (0.5 mg/kg) during rest resulted in a significant shortening of the PQ interval, indicating that the PQ interval can be ...

journal_title：European journal of pharmacology

authors： Nijsen MJ,Croiset G,Diamant M,Stam R,Delsing D,de Wied D,Wiegant VM

更新日期：1998-06-05 00:00:00

abstract：:A novel growth hormone secretagogues type 1a (GHS1a) receptors antagonist (2R)-N'-[3,5- bis(trifluoromethyl)phenyl]-2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(3- pyridinyl)ethanohydrazide (GSK1614343) was functionally characterised in rat pituitary adenoma cell line, RC-4B/C endogenously expressing GHS1a rec...

journal_title：European journal of pharmacology

authors： Perdonà E,Faggioni F,Buson A,Sabbatini FM,Corti C,Corsi M

更新日期：2011-01-10 00:00:00

abstract：:We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro. KB-5666 (3-100 microM) inhibited lipid peroxidation in brain homogenate...

journal_title：European journal of pharmacology

authors： Hara H,Kogure K,Kato H,Ozaki A,Sukamoto T

更新日期：1991-05-02 00:00:00

abstract：:The inhibitors of advanced glycation endproduct and oxidative stress, as well as N-methyl-d-aspartate (NMDA) receptor antagonists have received considerable interest because of their close association with renoprotective effects. The therapeutic potential of 20(S)-ginsenoside Rg(3) (20(S)-Rg(3)), isolated from Panax g...

journal_title：European journal of pharmacology

authors： Kang KS,Yamabe N,Kim HY,Park JH,Yokozawa T

更新日期：2008-09-04 00:00:00

abstract：:High temperature requirement A2 (HtrA2)/Omi is a mitochondrial serine protease that is released into the cytosol from mitochondria and in turn promotes caspase activation by proteolyzing inhibitor of apoptosis proteins. Here we asked whether treatment with an HtrA2/Omi inhibitor, 5-[5-(2-nitrophenyl)furfuryliodine]-1,...

journal_title：European journal of pharmacology

authors： Bhuiyan MS,Fukunaga K

更新日期：2007-02-28 00:00:00

abstract：:The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties ...

journal_title：European journal of pharmacology

authors： Bottlaender M,Schmid L,Fuseau C,Fournier D,Brouillet E,Mazière M

更新日期：1997-02-19 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are drugs very effective to decrease low-density lipoprotein (LDL) cholesterol. In addition, a number of studies suggest that statins have other beneficial clinical effects beyond cholesterol lowering. We recently reported that statins decr...

journal_title：European journal of pharmacology

authors： Ortego M,Hernández AG,Bustos C,Blanco-Colio LM,Hernández-Presa MA,Tuñón J,Egido J

更新日期：2002-07-19 00:00:00

abstract：:[3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. [3H]Rauwolscine binding was reversible, stereospecific, and saturable. Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM,...

journal_title：European journal of pharmacology

authors： Perry BD,U'Prichard DC

更新日期：1981-12-17 00:00:00

abstract：:The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate ...

journal_title：European journal of pharmacology

authors： Arvola P,Pörsti I,Vuorinen P,Huhtala H,Metsä-Ketelä T,Vapaatalo H

更新日期：1992-04-22 00:00:00

abstract：:Activation of cannabinoid receptor 1 (CB1) inhibits synaptic transmission in hippocampal neurons. The goal of this study was to evaluate the ability of benchmark and emerging synthetic cannabinoids to suppress neuronal activity in vitro using two complementary techniques, Ca(2+) spiking and multi-electrode arrays (MEA...

journal_title：European journal of pharmacology

authors： Tauskela JS,Comas T,Hewitt M,Aylsworth A,Zhao X,Martina M,Costain WJ

更新日期：2016-09-05 00:00:00

abstract：:5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-pip...

journal_title：European journal of pharmacology

authors： Habara T,Hamamura T,Miki M,Ohashi K,Kuroda S

更新日期：2001-04-13 00:00:00

abstract：:Phasic release of calcium from the sarcoplasmic reticulum occurs in all mammalian cardiac preparations when the intracellular calcium concentration is sufficiently high. The phasic calcium release is often sufficient to trigger electrophysiological responses and aftercontractions. These can be detrimental to normal ca...

journal_title：European journal of pharmacology

authors： Briggs GM,Morgan JP,Gwathmey JK

更新日期：1989-11-07 00:00:00