Abstract：
:Gastric vascular responses to histamine and its selective H1- and H2-agonists in vitro were investigated in the isolated vascular-perfused stomach of rabbit and rat. In the rabbit stomach under resting conditions bolus injection of histamine (5-80 nmol) caused a small increase in perfusion pressure (PP). However, during infusion of noradrenaline (1 microM), which elevated vascular tone, histamine (5-80 nmol) caused a dose-dependent biphasic vascular response, an initial increase followed by a fall in PP. Under similar conditions, the H1-agonist 2-pyridyl ethylamine, (2-PE; 50-400 nmol) elevated PP, whereas the H2-agonist dimaprit (80-640 nmol) reduced PP. The H1-antagonist mepyramine (0.25 microM) converted the biphasic response of histamine (5-50 nmol) to a monophasic vasodilation whereas the H2-receptor antagonist, cimetidine (1 microM) converted the biphasic response to a vasoconstriction. Similar responses were observed during conditions of elevated vascular tone induced by vasopressin or angiotensin II. In the rat stomach, histamine and both dimaprit and 2-PE reduced PP during conditions of elevated vascular tone. These findings support the presence of both H1- and H2 receptors in the gastric vasculature of both rat and rabbit; in both species, the H2-response is vasodilation whereas the nature of the H1-response is species dependent.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Salvati P,Whittle BJdoi
10.1016/0014-2999(83)90608-8subject
Has Abstractpub_date
1983-04-22 00:00:00pages
63-8issue
1-2eissn
0014-2999issn
1879-0712pii
0014-2999(83)90608-8journal_volume
89pub_type
杂志文章abstract：:[D-Ala2,Met5]enkephalinamide (DAME), [D-Ala2,Leu5]enkephalinamide (DALE) and morphine sulfate (MS) increase activity in the recurrent laryngeal nerve (RLN) within 1 s subsequent to right atrial administration. The activation of the RLN was correlated with a large increase in the resistance to airflow in the in situ is...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(82)90177-7
更新日期：1982-05-07 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2001-06-01 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(82)90495-2
更新日期：1982-03-26 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1996-04-22 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90572-3
更新日期：1987-09-23 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1996-12-05 00:00:00
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更新日期：1987-06-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0922-4106(94)90071-x
更新日期：1994-08-16 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(88)90780-7
更新日期：1988-03-01 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(91)90407-h
更新日期：1991-04-10 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2019-01-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2005-03-14 00:00:00
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doi：10.1016/j.ejphar.2003.11.041
更新日期：2004-02-06 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1990-07-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1993-04-06 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(86)90338-9
更新日期：1986-09-23 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90407-9
更新日期：1987-09-02 00:00:00
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pub_type： 杂志文章
doi：10.1016/0014-2999(91)90149-k
更新日期：1991-02-14 00:00:00
abstract：:Sanguinarine is a natural isoquinoline alkaloid derived from the root of Sanguinaria canadensis and from other poppy fumaria species, and is known to have a broad spectrum of pharmacological properties. Here we have found that sanguinarine, at low micromolar concentrations, showed a remarkably rapid killing activity a...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2013-04-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90111-7
更新日期：1987-10-13 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(89)90361-0
更新日期：1989-08-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2009.12.005
更新日期：2010-03-10 00:00:00
abstract：:Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction,...
journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.ejphar.2018.04.003
更新日期：2018-06-15 00:00:00
