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cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation.

Abstract：

:The present study investigates the role of cGMP and cAMP on the memory performance in the object recognition task in rats. The analogue 8-Br-GMP or 8-Br-cAMP was administered bilaterally into the hippocampus (0, 1, 3 and 10 microg in 0.5 microl saline/site) immediately after the exposure to two identical objects. After 24 h, saline-treated animals spent equal times exploring a new and the familiar object demonstrating that they did not recognize the familiar one. However, a dose-dependent improvement in object recognition was found after injection of 8-Br-cGMP. In contrast, 8-Br-cAMP did not improve the memory performance at the doses tested. These results indicate that hippocampal cGMP but not cAMP is involved in early stages of consolidation of object memory.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Prickaerts J,de Vente J,Honig W,Steinbusch HW,Blokland A

doi

10.1016/s0014-2999(01)01614-4

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

83-7

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

S0014299901016144

journal_volume

436

pub_type

杂志文章

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