Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats.

abstract：:In bovine aortic endothelial cells (BAEC), pertussis toxin (PTx) ADP-ribosylated two major substrates with apparent molecular masses of 40 and 41 kDa, whereas cholera toxin (CTx) ADP-ribosylated two other substrates of 44 and 50 kDa. [alpha-32P]GTP bound to three bands in the 22-27 kDa range. Immunoblot analysis revea...

journal_title：European journal of pharmacology

authors： Gil-Longo J,Dufour MN,Guillon G,Lugnier C

更新日期：1993-10-15 00:00:00

abstract：:Rheumatoid Arthritis is a chronic autoimmune disease with a complex disease pathogenesis leading to inflammation and destruction of synovial tissue in the joint. Several molecules lead to activation of immune pathways, including autoantibodies, Toll-Like Receptor ligands and cytokines. These pathways can cooperate to ...

journal_title：European journal of pharmacology

authors： Suurmond J,van der Velden D,Kuiper J,Bot I,Toes RE

更新日期：2016-05-05 00:00:00

abstract：:The distribution of the binding of [3H]GR65630 (0.2 nM) to putative 5-HT3 recognition sites in the brain of the common marmoset was assessed using autoradiography. Specific binding was heterogeneously distributed with the highest densities found in discrete nuclei of the lower medulla (nucleus tractus solitarii, dorsa...

journal_title：European journal of pharmacology

authors： Jones DN,Barnes NM,Costall B,Domeney AM,Kilpatrick GJ,Naylor RJ,Tyers MB

更新日期：1992-04-29 00:00:00

abstract：:The interaction of 5 alpha-pregnane-3 alpha-ol-20-one (5 alpha 3 alpha P), a progesterone metabolite, with the GABAA receptor chloride channel complex was investigated at the pituitary level. In nanomolar concentrations this steroid potentiated the inhibitory effect of muscimol (a GABAA agonist) on prolactin release f...

journal_title：European journal of pharmacology

authors： Vincens M,Shu C,Moguilewsky M,Philibert D

更新日期：1989-09-01 00:00:00

abstract：:The occurrence and characteristics of binding sites specific for gamma-aminobutyric acid (GABA) and muscimol in the rat stomach were examined by biochemical and autoradiographic techniques, and the effects of GABAergic model compounds on gastric ulceration induced by chemical irritation was studied in intact and unila...

journal_title：European journal of pharmacology

authors： Erdö SL,Ezer E,Matuz J,Wolff JR,Amenta F

更新日期：1989-06-08 00:00:00

abstract：:Previous studies from this laboratory have shown that administration of nitric oxide (NO) donors reduces the early phase (which peaks at 4 h) of carrageenan-induced paw oedema. The aim of this study was to investigate the influence of NO donors on the delayed phase of the mouse paw oedema, which peaks 48 h after carra...

journal_title：European journal of pharmacology

authors： Fernandes D,Assreuy J

更新日期：2004-10-06 00:00:00

abstract：:A single undrugged experience of the elevated plus-maze modifies future drug responses in the test. The present study investigated the effects of maze-experience on the acute behavioral effects of the monoamine oxidase inhibitor phenelzine and the serotonin reuptake inhibitor fluoxetine. Phenelzine (2.5-12.5 mg/kg) ha...

journal_title：European journal of pharmacology

authors： Holmes A,Rodgers RJ

更新日期：2003-01-17 00:00:00

abstract：:Intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of morphine (10 micrograms or 25 mg/kg, respectively) increased the mortality rate in experimental anaphylaxis in mice. This effect was blocked by the opiate antagonist naltrexone administered systemically (5 mg/kg) or i.c.v. (10 micrograms). Moreov...

journal_title：European journal of pharmacology

authors： Amir S

更新日期：1983-11-11 00:00:00

abstract：:Cyclosporin A is shown to attenuate antinociceptive effects of morphine, development and expression of morphine-induced tolerance and dependency via nitric oxide (NO) pathway. In the present study, the effect of systemic cyclosporin A on morphine-induced conditioned place preference (CPP) and the probable involvement ...

journal_title：European journal of pharmacology

authors： Motiei Langroudi R,Khoshnoodi MA,Abadi NY,Tahsili Fahadan P,Ghahremani MH,Dehpour AR

更新日期：2005-01-10 00:00:00

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:Malignant gliomas are the most common primary brain tumors. Due to both their invasive nature and resistance to multimodal treatments, these tumors have a very high percentage of recurrence leading in most cases to a rapid fatal outcome. Recent data demonstrated that neural stem/progenitor cells possess an inherent ab...

journal_title：European journal of pharmacology

authors： Ginisty A,Oliver L,Arnault P,Vallette F,Benzakour O,Coronas V

更新日期：2019-07-15 00:00:00

abstract：:Three peptide components of atrial natriuretic factor (ANF) caused relaxation of carbachol-contracted guinea-pig isolated tracheal smooth muscle. These were the 1-28, 5-28 and 5-27 peptide sequences (ANF(1-28), ANF-(5-28) and ANF-(5-27)). The peptides were 10-30 times more potent in epithelium-denuded than in epitheli...

journal_title：European journal of pharmacology

authors： Fernandes LB,Preuss JM,Goldie RG

更新日期：1992-03-03 00:00:00

abstract：:Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

journal_title：European journal of pharmacology

authors： Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

更新日期：1996-06-13 00:00:00

abstract：:In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. Cross-tachyphylaxis and additivity experiments evidenced distinct receptors for these agonists. BQ-...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Matsuda Y,Paiva AC,Rae GA

更新日期：1999-03-19 00:00:00

abstract：:Previous work has demonstrated that neuropeptide tyrosine (NPY), Y(1) receptor and Y(2) receptor are critical in modulation of pain after nerve injury. We hypothesized that NPY was important for nociception after surgical incision. As a model of postoperative pain, rats underwent a plantar incision in one hindpaw. Wes...

journal_title：European journal of pharmacology

authors： Yalamuri SM,Brennan TJ,Spofford CM

更新日期：2013-01-05 00:00:00

abstract：:We have described here the changes of the biophysical and pharmacological properties of the sarcolemmal ATP-sensitive K+ channels (KATP) of rat skeletal muscle fibres, occurring from an early postnatal period (5 days) to adulthood (210 days). The age-dependent changes of the mean current of the KATP channel (channel a...

journal_title：European journal of pharmacology

authors： Tricarico D,Petruzzi R,Conte Camerino DC

更新日期：1997-03-05 00:00:00

abstract：:Previous studies show that naringenin promotes insulin sensitivity in fructose-fed rats. This study investigates whether naringenin prevents oxidative events and apoptotic changes triggered in the rat liver by a high fructose diet. Male Wistar rats of body weight 150-180 g were fed either diet containing starch (60% c...

journal_title：European journal of pharmacology

authors： Kannappan S,Palanisamy N,Anuradha CV

更新日期：2010-10-25 00:00:00

abstract：:The vascular response to most neurotransmitters of different vascular beds is altered under hypertensive condition. The modulatory effect of genetic pulmonary arterial hypertension on histamine responses is not known. The present study was undertaken to evaluate the modulatory effect of enzymatic degradation (via hist...

journal_title：European journal of pharmacology

authors： Lau WH,Kwan YW,Au AL,Cheung WH

更新日期：2003-05-30 00:00:00

abstract：:Soluble amyloid β-protein (Aβ) oligomers are primary mediators of synaptic dysfunction associated with the progression of Alzheimer's disease. Such Aβ oligomers exist dependent on their rates of aggregation and metabolism. Use of selective somatostatin receptor-subtype agonists have been identified as a potential mean...

journal_title：European journal of pharmacology

authors： Sandoval KE,Farr SA,Banks WA,Crider AM,Morley JE,Witt KA

更新日期：2012-05-15 00:00:00

abstract：:There is increasing evidence in support of an important role played by neurotensin (NT), a tridecapeptide originally found in bovine hypothalamus, in regulation of cardiovascular system. Elevated systemic levels of NT may contribute to pathogenesis of acute circulatory disoders, and predict the risk for cardiovascular...

journal_title：European journal of pharmacology

authors： Osadchii OE

更新日期：2015-09-05 00:00:00

abstract：:Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-D...

journal_title：European journal of pharmacology

authors： Quock RM,Lucas TS

更新日期：1983-11-25 00:00:00

abstract：:Although, several effects of glucosamine and its sulfated form (sulfated glucosamine) have been proposed for the suppression of osteoarthritis, their exact mechanisms have not been completely elucidated. This study explains the novel possibility of involvement of sulfated glucosamine in improving cellular antioxidant ...

journal_title：European journal of pharmacology

authors： Mendis E,Kim MM,Rajapakse N,Kim SK

更新日期：2008-01-28 00:00:00

abstract：:The aim was to determine whether blockade of store-operated Ca(2+) entry, or inhibition of Ca(2+) sensitisation, is the predominant mechanism by which neuronally released nitric oxide mediates relaxation of the mouse anococcygeus. Nitrergic relaxations to field stimulation (10 Hz, 10 s trains) were unaffected by the s...

journal_title：European journal of pharmacology

authors： Gibson A,Wallace P,McFadzean I

更新日期：2003-06-27 00:00:00

abstract：:The purposes of the present study were to clarify whether some Cl(-) channels exist in rat pleural mesothelial cells, and to investigate functional and molecular characteristics of these channels. Electrophysiological recordings were performed at room temperature using the whole-cell configuration of the patch-clamp t...

journal_title：European journal of pharmacology

authors： Yoshise Y,Ito K,Tsubone H,Kuwahara M

更新日期：2009-07-01 00:00:00

abstract：:To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. E...

journal_title：European journal of pharmacology

authors： He Y,Zeng H,Yu Y,Zhang J,Liu Q,Yang B

更新日期：2017-11-15 00:00:00

abstract：:There is a large body of evidence to suggest that the sympathetic nervous system plays a critical role in the development of hypertension and vascular medial hypertrophy in the spontaneously hypertensive rat (SHR). The synthesis of a water soluble, specific alpha 1-adrenoceptor antagonist (terazosin) has permitted an ...

journal_title：European journal of pharmacology

authors： Jonsson JR,Head RJ,Frewin DB

更新日期：1992-02-11 00:00:00

abstract：:The vasodepressor actions of the cyclic endoperoxides PGG2 and PGH2 were compared with those of their products PGD2 and PGE2 using anaesthetised normotensive and genetically hypertensive rats. Given into the aortic arch of normotensives PGE2 was approximately 6 times more potent than PGH2 and 11 times more potent tha...

journal_title：European journal of pharmacology

authors： Armstrong JM,Boura AL,Hamberg M,Samuelsson B

更新日期：1976-10-01 00:00:00

abstract：:The effects of endothelin-1 on normal and everted rabbit aorta rings and on cultured rat aortic smooth muscle cells were studied. Endothelin-1 (40 nM) contracted both normal and everted rings, and was still able to induce a prolonged contraction in Ca2(+)-free medium. Treatment of cultured cells with 100 nM endothelin...

journal_title：European journal of pharmacology

authors： Miasiro N,Paiva AC

更新日期：1990-04-10 00:00:00

abstract：:d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions prod...

journal_title：European journal of pharmacology

authors： Zhang L,Dyer DC

更新日期：1993-01-05 00:00:00

abstract：:Cervical cancer is the third most prevalent cancer among women worldwide. Theanine from tea and its derivatives show some anticancer activities. However, the role of theanine and its derivatives against human cervical cancer and the molecular mechanisms of action remain unclear. Thus, in this study, we aim to investig...

journal_title：European journal of pharmacology

authors： Liu J,Sun Y,Zhang H,Ji D,Wu F,Tian H,Liu K,Zhang Y,Wu B,Zhang G

更新日期：2016-11-15 00:00:00