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Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy.

Abstract：

:d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Zhang L,Dyer DC

doi

10.1016/0014-2999(93)90420-m

subject

Has Abstract

pub_date

1993-01-05 00:00:00

pages

115-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90420-M

journal_volume

230

pub_type

杂志文章

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