Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats.

abstract：:The administration to mice of 1-methyl-4-(2'-methylphenyl)-1,2,3, 6-tetrahydropyridine (2'-CH3-MPTP), a substituted analog of the dopaminergic neurotoxin MPTP caused even more dopaminergic toxicity than MPTP itself. Under conditions in which MPTP was relatively ineffective (i.e. two injections per day of 0.113 mmol/kg...

journal_title：European journal of pharmacology

authors： Youngster SK,Duvoisin RC,Hess A,Sonsalla PK,Kindt MV,Heikkila RE

更新日期：1986-03-18 00:00:00

abstract：:The intravenous infusion of catecholamines to rats induced a dose dependent increase of immunoreactive beta-endorphin (beta-Endi) in plasma. The ED50 values of 1-epinephrine and 1-isoproterenol were 110 and 100 ng/kg X min respectively. 1-Propranolol, but not d-propranolol prevented the effect of 1-epinephrine. Infusi...

journal_title：European journal of pharmacology

authors： Berkenbosch F,Vermes I,Tilders FJ

更新日期：1981-06-10 00:00:00

abstract：:Identification of the roles of epigenetic alterations in cancers has suggested that different molecules involved in this process are potentially therapeutic targets. Given the role of histone deacetylases (HDACs) enzymes in leukemogenesis, we designed a study to investigate the anti-leukemic property of panobinostat, ...

journal_title：European journal of pharmacology

authors： Mehrpouri M,Safaroghli-Azar A,Pourbagheri-Sigaroodi A,Momeny M,Bashash D

更新日期：2020-05-15 00:00:00

abstract：:Melatonin, an emphatic endogenous molecule exerts protective effects either via activation of G-protein coupled receptors (Melatonin receptors, MTR 1-3), tumor necrosis factor receptor (TNFR), toll like receptors (TLRS), nuclear receptors (NRS) or by directly scavenging the free radicals. MTRs are extensively expresse...

journal_title：European journal of pharmacology

authors： Randhawa PK,Gupta MK

更新日期：2020-10-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by an airways inflammation and by an enhanced generation of reactive oxygen species. The aim of our study was to assess the inflammation and the oxidative stress in airways of COPD patients with acute exacerbation of disease and in stability. Furthermore, w...

journal_title：European journal of pharmacology

authors： Carpagnano GE,Resta O,Foschino-Barbaro MP,Spanevello A,Stefano A,Di Gioia G,Serviddio G,Gramiccioni E

更新日期：2004-11-28 00:00:00

abstract：:In this study, we examined the effects of Salvia miltiorrhiza (Danshen) crude extract, some of its lipid-soluble components (tanshinone I, tanshinone II(A), cryptotanshinone, dihydroisotanshinone I) and the water-soluble compounds (danshensu and salvianolic acid B) on the K(+) channels such as the iberiotoxin-sensitiv...

journal_title：European journal of pharmacology

authors： Lam FF,Seto SW,Kwan YW,Yeung JH,Chan P

更新日期：2006-09-28 00:00:00

abstract：:The Kd values of the multiple agonist binding sites in cardiac muscarinic receptors (mAChR) and pD2 values for negative inotropic actions were determined independently and their relation was examined. The guinea-pig cardiac mAChR is known to have three agonist binding sites (super-high (SH), high (H) and low (L) affin...

journal_title：European journal of pharmacology

authors： Mizushima A,Uchida S,Matsumoto K,Osugi T,Kagiya T,Zhou XM,Higuchi H,Yoshida H

更新日期：1985-12-17 00:00:00

abstract：:Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced excitatory pain neu...

journal_title：European journal of pharmacology

authors： Tumati S,Milnes TL,Yamamura HI,Vanderah TW,Roeske WR,Varga EV

更新日期：2008-12-28 00:00:00

abstract：:The effects of local application of a cream containing nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine (SNAP) or isosorbide dinitrate were studied in a rat model of incision pain. An incision was made in the plantar aspect of a hind paw and the cream was applied inside the surgical wound. SNAP (1-10%) or iso...

journal_title：European journal of pharmacology

authors： Prado WA,Schiavon VF,Cunha FQ

更新日期：2002-04-19 00:00:00

abstract：:The involvement of delta opioid receptors in supraspinal analgesia was investigated. With this aim, opioids that produced analgesia in the tail immersion test were administered i.c.v. to mice a few minutes before the irreversible antagonist, beta-funaltrexamine (beta-FNA). Protection of the respective analgesic effect...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1989-01-02 00:00:00

abstract：:Corticotropin releasing factor (CRF) is a hypothalamic hormone that also displays autocrine/paracrine roles at peripheral sites. High concentrations of CRF have been identified in endothelial cells and other inflammatory tissues. We investigated the effects of CRF and antagonists in the regulation of prostaglandin syn...

journal_title：European journal of pharmacology

authors： Fleisher-Berkovich S,Rimon G,Danon A

更新日期：1998-07-24 00:00:00

abstract：:The effects of acute treatment with sibutramine on the peripheral sympathetic neurotransmission in vas deferens of young rats were still not evaluated. Therefore, we carried out this study in order to verify the effects of acute sibutramine treatment on the neuronal- and exogenous agonist-induced contractions of the y...

journal_title：European journal of pharmacology

authors： de Souza BP,da Silva ED Jr,Jurkiewicz A,Jurkiewicz NH

更新日期：2014-09-05 00:00:00

abstract：:Ca2+-handling disturbances play an important role in the genesis of myocardial ischemia/reperfusion (I/R) injury. Ischemic preconditioning (IPC) is a powerful strategy to induce tolerance against subsequent ischemic episodes. IPC signaling pathways may be triggered by Ca2+ ion. Since Na+/Ca2+ exchanger 1 (NCX1) partic...

journal_title：European journal of pharmacology

authors： Castaldo P,Macrì ML,Lariccia V,Matteucci A,Maiolino M,Gratteri S,Amoroso S,Magi S

更新日期：2017-01-05 00:00:00

abstract：:In anesthetized, artificially ventilated guinea pigs immunized against ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a substantial and sustained increase of insufflation pressure. The inhibitor of endogenous nitric oxide (NO) synthesis, L-NAME (N omega-nitro-L-arginine methylester, 30 mg kg-1 i.v.)...

journal_title：European journal of pharmacology

authors： Persson MG,Friberg SG,Hedqvist P,Gustafsson LE

更新日期：1993-11-16 00:00:00

abstract：:The anti-inflammatory activity of avarol and avarone, sesquiterpenoid derivatives from the Mediterranean sponge Dysidea avara, was investigated. Both compounds potently inhibited paw oedema induced by carrageenan (approximated ED50 = 9.2 and 4.6 mg/kg, p.o., respectively) as well as ear oedema induced by 12-O-tetradec...

journal_title：European journal of pharmacology

authors： Ferrándiz ML,Sanz MJ,Bustos G,Payá M,Alcaraz MJ,De Rosa S

更新日期：1994-02-21 00:00:00

abstract：:Eating disorders constitute major medical health problems in the western world. Even though little is known about the mechanisms behind abnormal eating behavior, it has become clear that the central nervous system (CNS), particularly the hypothalamus, plays a significant role. The anorexic anx/anx mouse is a unique mo...

journal_title：European journal of pharmacology

authors： Johansen JE,Fetissov S,Fischer H,Arvidsson S,Hökfelt T,Schalling M

更新日期：2003-11-07 00:00:00

abstract：:To elucidate the mechanism of age-related changes in the cardiovascular function stimulated with angiotensin II, we examined the effects of angiotensin II on the coronary flow, production of nitric oxide (NO) and prostacyclin, and on the cardiac function in the Langendorff-perfused young and aged rats' hearts. Angiote...

journal_title：European journal of pharmacology

authors： Ishihata A,Katano Y,Nakamura M,Doi K,Tasaki K,Ono A

更新日期：1999-10-01 00:00:00

abstract：:Substituted benzamides such as metoclopramide, cisapride, zacopride, renzapride or BRL 20627, stimulate intestinal motility in various species. As they are antagonists at 5-HT3 and agonists at 5-HT4 receptors and as both mechanisms could potentially contribute to their gastrointestinal prokinetic effect, the underlyin...

journal_title：European journal of pharmacology

authors： Buchheit KH,Buhl T

更新日期：1991-11-26 00:00:00

abstract：:We have assessed the capacity of two novel inhibitors to block cytokine-induced nitric oxide (NO) synthesis by macrophages and vascular smooth muscle cells, as well as NO production by the constitutive enzyme in central nervous system tissue. NG-Cyclopropyl-L-arginine selectively inhibited Ca2+/calmodulin-dependent NO...

journal_title：European journal of pharmacology

authors： Lambert LE,French JF,Whitten JP,Baron BM,McDonald IA

更新日期：1992-05-27 00:00:00

abstract：:Although a number of muscarinic agonists have been used in clinical trials for Alzheimer's Disease, many of these compounds are low in potency and have only limited intrinsic efficacy. The present study describes four non-quaternary oxadiazole based muscarinic agonists from a quinuclidine and a 1-azanorbornane series....

journal_title：European journal of pharmacology

authors： Freedman SB,Harley EA,Marwood RS,Patel S

更新日期：1990-10-09 00:00:00

abstract：:The in vivo cardiovascular effect and in vitro vasorelaxant effect of harman, one of harmala alkaloids isolated from Peganum harmala, were examined in this study. Harman (1-10 mg/kg, i.v.) dose-dependently produced transient hypotension and long-lasting bradycardia in pentobarbital-anesthetized rats, which were attenu...

journal_title：European journal of pharmacology

authors： Shi CC,Chen SY,Wang GJ,Liao JF,Chen CF

更新日期：2000-03-03 00:00:00

abstract：:Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as ...

journal_title：European journal of pharmacology

authors： Melchiorri D,Reiter RJ,Chen LD,Sewerynek E,Nisticò G

更新日期：1996-06-03 00:00:00

abstract：:This study examined alterations in the beta-adrenoceptor-G5-adenylyl cyclase system in cerebral cortex membranes from vitamin B12-deficient rats fed a diet lacking vitamin B12 (mecobalamin) for 15 weeks. Basal, 5(7)-guanylylimidodiphosphate (GppNHp)-, isoproterenol-, and forskolin-stimulated adenylyl cyclase activitie...

journal_title：European journal of pharmacology

authors： Hatta S,Watanabe M,Ikeda H,Kamada H,Saito T,Ohshika H

更新日期：1995-11-30 00:00:00

abstract：:The molecular mechanisms regulating the trafficking of the CRTH2 receptor are poorly understood. In the present study, we characterize C-terminal tail determinants involved in the agonist-induced trafficking of the CRTH2 receptor for prostaglandin D(2). Our results showed that progressive deletion of C-terminal tail r...

journal_title：European journal of pharmacology

authors： Roy SJ,Parent A,Gallant MA,de Brum-Fernandes AJ,Stanková J,Parent JL

更新日期：2010-03-25 00:00:00

abstract：:To determine if an Ag(+)-induced contracture is associated with the Ca(2+)-induced Ca2+ release mechanism in the sarcoplasmic reticulum, effects of Ca(2+)-induced Ca2+ release modulators on the Ag(+)-induced contracture were studied with single fibers of frog toe skeletal muscle. The fiber treated with 1 mM caffeine c...

journal_title：European journal of pharmacology

authors： Oba T,Nihonyanagi K,Yamaguchi M

更新日期：1995-03-16 00:00:00

abstract：:The stress-induced hyperthermia procedure, in which effects of drugs on basal (T(1)) and stress-induced body temperature (T(2)) are measured, predicts anxiolytic drug effect. Serotonergic drugs alter these responses and here, we studied the role of 5-HT(1A) receptors in stress-induced hyperthermia by using 5-HT(1A) re...

journal_title：European journal of pharmacology

authors： Van Bogaert M,Oosting R,Toth M,Groenink L,van Oorschot R,Olivier B

更新日期：2006-11-21 00:00:00

abstract：:We previously reported the synthesis of three new opioid agonists as well as their in vitro and in vivo activity [Girón, R., Abalo, R., Goicoechea, C., Martín, M.I., Callado, L.F., Cano, C., Goya, P., Jagerovic, N. 2002. Synthesis and opioid activity of new fentanyl analogs. Life Sci. 71, 1023-1034]. One of them, N-[1...

journal_title：European journal of pharmacology

authors： Goicoechea C,Sánchez E,Cano C,Jagerovic N,Martín MI

更新日期：2008-10-24 00:00:00

abstract：:In pregnant rat myometrium, isoproterenol (10(-8) M) inhibited spontaneous contractions without causing hyperpolarization. Isoproterenol (10(-6) M) relaxed the depolarized muscle without affecting the membrane potential. The presence of 80 mM Na+ did not affect the degree of high-K+ depolarization. It was also without...

journal_title：European journal of pharmacology

authors： Meisheri KD,McNeill JH,Marshall JM

更新日期：1979-11-23 00:00:00

abstract：:Cultured retina cells released accumulated [3H]GABA (gamma-aminobutyric acid) when stimulated by L-glutamate, N-methyl-D-aspartate (NMDA) and kainate. In the absence of Mg2+, dopamine at 200 microM (IC50 60 microM), inhibited in more than 50% the release of [3H]GABA induced by L-glutamate and NMDA, but not by kainate....

journal_title：European journal of pharmacology

authors： Do Nascimento JL,Kubrusly RC,Reis RA,De Mello MC,De Mello FG

更新日期：1998-02-05 00:00:00

abstract：:The involvement of spinal glial cells in the nociceptive behaviors induced by 1600 pmol of histamine was determined in mice. Histamine injected intrathecally (i.t.) produced nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by histamine were significantly suppressed...

journal_title：European journal of pharmacology

authors： Mizoguchi H,Komatsu T,Iwata Y,Watanabe C,Watanabe H,Orito T,Katsuyama S,Yonezawa A,Onodera K,Sakurada T,Sakurada S

更新日期：2011-02-25 00:00:00