Effect of isoproterenol on the isolated pregnant rat myometrium.

Abstract:

:In pregnant rat myometrium, isoproterenol (10(-8) M) inhibited spontaneous contractions without causing hyperpolarization. Isoproterenol (10(-6) M) relaxed the depolarized muscle without affecting the membrane potential. The presence of 80 mM Na+ did not affect the degree of high-K+ depolarization. It was also without any influence on the effects of isoproterenol on the depolarized uterus. The results are consistent with the concept that hyperpolarization is not a prerequisite for beta-adrenoceptor induced relaxation of uterine smooth muscle.

journal_name

Eur J Pharmacol

authors

Meisheri KD,McNeill JH,Marshall JM

doi

10.1016/0014-2999(79)90045-1

subject

Has Abstract

pub_date

1979-11-23 00:00:00

pages

1-6

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(79)90045-1

journal_volume

60

pub_type

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