5-Hydroxytryptamine stimulates the release of prostacyclin but not thromboxane A2 from isolated rat dental pulp.

abstract：:1-(Meta-chloro)phenylpiperazine (m-CPP) is a 5-HT receptor agonist which has been purported to be relatively selective for the 5-HT2C receptor. In particular, the hypolocomotion produced by m-CPP has been suggested to be mediated by 5-HT2C receptors. m-CPP binds with high affinity to 5-HT1 as well as 5-HT2 receptors, ...

journal_title：European journal of pharmacology

authors： Gleason SD,Shannon HE

更新日期：1998-01-12 00:00:00

abstract：:In conscious normotensive cats intraventricular (i.c.v.) administration of histamine (2.0-50.0 mug) induced dose-related rises in blood pressure, with no increase in heart rate. The hypertensive response elicited by a sub-maximal dose of histamine (10.0 mu i.c.v.) was significantly antagonised by central pretreatment ...

journal_title：European journal of pharmacology

authors： Finch L,Hicks PE

更新日期：1976-03-01 00:00:00

abstract：:The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection o...

journal_title：European journal of pharmacology

authors： Kobari M,Tomita M,Tanahashi N,Yokoyama M,Takao M,Fukuuchi Y

更新日期：1996-12-19 00:00:00

abstract：:Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as ...

journal_title：European journal of pharmacology

authors： Roth BL,Ciaranello RD

更新日期：1991-06-19 00:00:00

abstract：:Melatonin protection against in vitro kainic acid-induced oxidative damage in rat brain is shown. Brain disrupted cell homogenates were incubated with different concentrations of kainate and with or without different concentrations of melatonin. The concentration of malonaldehyde and 4-hydroxyalkenals was measured as ...

journal_title：European journal of pharmacology

authors： Melchiorri D,Reiter RJ,Chen LD,Sewerynek E,Nisticò G

更新日期：1996-06-03 00:00:00

abstract：:The purpose of the present study was to characterize the nature of the behavioural response to substance P (SP) infusion into the substantia nigra and to evaluate this response in 6-hydroxydopamine (6-OHDA) caudate lesioned rats. The effects of SP infusions (3 microgram in 1 microliter bilaterally) were assessed in an...

journal_title：European journal of pharmacology

authors： Kelley AE,Iversen SD

更新日期：1979-12-07 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:The administration of a small dose of apomorphine (50 micrograms/kg s.c.) induced repeated episodes of yawning in male rats. Short-term (3 days) treatment with 17 beta-estradiol antagonized apomorphine-induced yawning in male rats. Moreover, apomorphine induced yawning much less effectively in female than in male rats...

journal_title：European journal of pharmacology

authors： Serra G,Collu M,Serra A,Gessa GL

更新日期：1984-09-17 00:00:00

abstract：:The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The s...

journal_title：European journal of pharmacology

authors： Li Y,Matsuda H,Wen S,Yamahara J,Yoshikawa M

更新日期：2000-01-17 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:The antinociceptive effect of nitrous oxide (N(2)O) is dependent on nitric oxide (NO); however, the next step in the pathway activated by NO is undetermined. The present study was conducted to test the hypothesis that a N(2)O action involves sequential activation of NO synthase, soluble guanylyl cyclase and protein ki...

journal_title：European journal of pharmacology

authors： Zhang Y,Quock LP,Chung E,Ohgami Y,Quock RM

更新日期：2011-03-11 00:00:00

abstract：:We investigated the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on macromolecule extravasation in the microcirculation of awake hamsters by computer-assisted image analysis of the distribution of FITC (fluorescein isothiocyanate)-dextran fluorescence in dorsal fold skin preparations. This analy...

journal_title：European journal of pharmacology

authors： Gimeno G,Carpentier PH,Desquand-Billiald S,Hanf R,Finet M

更新日期：1998-04-10 00:00:00

abstract：:Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulatio...

journal_title：European journal of pharmacology

authors： Lu C,Zhao AX,Gao YJ,Lee RM

更新日期：2011-04-25 00:00:00

abstract：:In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats. Intracerebroventricular (i.c.v.) 0.5, 1.0 and 2.0 µmol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, b...

journal_title：European journal of pharmacology

authors： Kiyici S,Basaran NF,Cavun S,Savci V

更新日期：2015-10-05 00:00:00

abstract：:The pH dependence of the facilitation by dopamine (10 microM), 5-hydroxytryptamine (10 microM), adenosine (1 and 100 microM), Zn2+ (10 microM) and Cd2+ (1 mM) of P2X2 purinoceptor/channels was tested by expressing these channels in Xenopus oocytes. In a pH range between 6.0 and 8.5, concentration-response curves for a...

journal_title：European journal of pharmacology

authors： Nakazawa K,Liu M,Inoue K,Ohno Y

更新日期：1997-10-22 00:00:00

abstract：:Pulmonary hypertension is a progressive disease of various origins that is associated with right ventricular dysfunction. In the present study, the protective effect of diosgenin was investigated in monocrotaline-induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous inject...

journal_title：European journal of pharmacology

authors： Ahmed LA,Obaid AA,Zaki HF,Agha AM

更新日期：2014-10-05 00:00:00

abstract：:In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate ...

journal_title：European journal of pharmacology

authors： Hoyle CH,Chapple C,Burnstock G

更新日期：1989-12-12 00:00:00

abstract：:[14C]Guanidinium ion influx into Na+ channel preparations from mouse and rat cerebral cortex (purified synaptosomes, and synaptoneurosomes) was characterized and its properties were compared with those for 22Na+ influx. Tetrodotoxin-sensitive influx of [14C]guanidinium ion was stimulated by aconitine, veratridine, and...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1990-01-23 00:00:00

abstract：:7-Nitroindazole (a selective neuronal nitric oxide (NO) synthase inhibitor) at 25 and 50 mg/kg, 30 min before the test, did not influence the electroconvulsive threshold. However, at 50 mg/kg, it enhanced the anticonvulsive activity of phenobarbital against maximal electroshock and did not affect that of carbamazepine...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-07-23 00:00:00

abstract：:Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and...

journal_title：European journal of pharmacology

authors： Hansen HH,Andreasen JT,Weikop P,Mirza N,Scheel-Krüger J,Mikkelsen JD

更新日期：2007-09-10 00:00:00

abstract：:Despite ample in vitro evidence that myofilament Ca(2+)-responsiveness of stunned myocardium is decreased, in vivo data are inconclusive. Conversely, while Ca(2+)-sensitizing agents increase myofilament Ca(2+)-responsiveness in vitro, it has been questioned whether this also occurs in vivo. We therefore tested in open...

journal_title：European journal of pharmacology

authors： de Zeeuw S,Trines SA,Krams R,Duncker DJ,Verdouw PD

更新日期：2000-09-01 00:00:00

abstract：:B cell antigen presentation, cytokine production, and antibody production are targets of pharmacological intervention in inflammatory and infectious diseases. Here we review recent pre-clinical evidence demonstrating that pharmacologically relevant levels of n-3 polyunsaturated fatty acids (PUFA) derived from marine f...

journal_title：European journal of pharmacology

authors： Whelan J,Gowdy KM,Shaikh SR

更新日期：2016-08-15 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:We examined the effects of YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate), a novel 5-HT3 receptor agonist, on gastrointestinal functions including visceral pain reflex in rats. Injection of YM-31636 increased the number of fecal pellets. This effect was completely inhibited by ramosetron, ...

journal_title：European journal of pharmacology

authors： Kiso T,Ito H,Miyata K,Kamato T,Naitoh Y,Iwaoka K,Yamaguchi T

更新日期：2001-11-09 00:00:00

abstract：:PCA 50941 is a novel 1,4-dihydropyridine derivative. Its vasoconstricting effects prompted a systematic comparison with the prototypic Ca2+ channel activator, Bay K 8644. The two compounds exhibit marked analogies and differences in their cardiovascular profiles. PCA 50941 exhibits a pronounced vascular over cardiac s...

journal_title：European journal of pharmacology

authors： Priego J,González-Morales MA,Cillero FJ,Villarroya M,Sunkel C,de Casa-Juana MF,López MG,Artalejo CR,de Pascual R,García AG

更新日期：1993-10-12 00:00:00

abstract：:The inhibitory actions of the Ca2+ antagonist Cd2+, morphine and noradrenaline (exogenously added + endogenously released) on electrically evoked release of [3H]noradrenaline from superfused rat neocortical slices were strongly reduced when release was enhanced by 4-aminopyridine. In the presence of 4-aminopyridine th...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Mulder AH

更新日期：1983-03-04 00:00:00

abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

journal_title：European journal of pharmacology

authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

更新日期：1992-10-01 00:00:00

abstract：:Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclin...

journal_title：European journal of pharmacology

authors： Kumar A,Ekavali,Chopra K,Mukherjee M,Pottabathini R,Dhull DK

更新日期：2015-08-15 00:00:00

abstract：:Nicotine produced antinociception in mice which was antagonized noncompetitively by naloxone. In addition, at significantly lower doses, nicotine noncompetitively antagonized morphine-induced antinociception. A speculative suggestion regarding the opiatergic and anti-opiatergic actions of nicotine is that it significa...

journal_title：European journal of pharmacology

authors： Aceto MD,Scates SM,Ji Z,Bowman ER

更新日期：1993-12-01 00:00:00