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Effects of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction.

Abstract：

:This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet rats treated with folic acid, vitaminB₆ and vitaminB₁₂ (Met+F), or with low-dose allicin (Met+L), or with high-dose allicin (Met+H). After 6 weeks, we collected blood samples of all groups to determine plasma endothelin (ET), serum homocysteine (Hcy), nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA), and detected the expression of basic fibroblast growth factors (bFGF), transforming growth factor beta (TGF-β), tumor necrosis factor-alpha (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) in the aorta. The Hcy and the expression of TGF-β in both the Met+L and Met+H groups were significantly lower than the Met and Met+F groups. The ET, ET/NO ratio and the MDA levels of the Met+L and Met+H groups were significantly lower than the Met group. The SOD and NO levels and the expression of bFGF, TNF-α and ICAM-1 of the Met+L and Met+H groups were significantly higher than the Met group. Our data indicate that allicin inhibits lipid peroxidation induced by hyperhomocysteinemia and regulates the excretion and equilibrium of ET and NO, and suggest that allicin might be useful in the prevention of endothelial dysfunction caused by hyperhomocysteinemia.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Liu DS,Gao W,Liang ES,Wang SL,Lin WW,Zhang WD,Jia Q,Guo RC,Zhang JD

doi

10.1016/j.ejphar.2013.05.038

subject

Has Abstract

pub_date

2013-08-15 00:00:00

pages

163-9

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(13)00456-1

journal_volume

714

pub_type

杂志文章

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