Abstract:
:This review selectively explores some areas of pain research that, until recently, have been poorly understood. We have chosen four topics that relate to clinical pain and we discuss the underlying mechanisms and related pathophysiologies contributing to these pain states. A key issue in pain medicine involves crucial events and mediators that contribute to normal and abnormal pain signaling, but remain unseen without genetic, biomarker or imaging analysis. Here we consider how the altered genetic make-up of familial pains reveals the human importance of channels discovered by preclinical research, followed by the contribution of receptors as stimulus transducers in cold sensing and cold pain. Finally we review recent data on the neuro-immune interactions in chronic pain and the potential targets for treatment in cancer-induced bone pain.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Sikandar S,Patel R,Patel S,Sikander S,Bennett DL,Dickenson AHdoi
10.1016/j.ejphar.2013.01.069subject
Has Abstractpub_date
2013-09-15 00:00:00pages
188-202issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(13)00168-4journal_volume
716pub_type
杂志文章,评审abstract::We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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