The role of alpha 1-adrenoceptor subtypes in the regulation of arterial blood pressure.

abstract：:The atypical beta-adrenoceptors mediating relaxation in the guinea pig duodenum were studied using catecholamines (isoprenaline, noradrenaline and adrenaline), a selective beta3-adrenoceptor agonist BRL37344 ((R*,R*)-(+/-)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]phe noxyacetic acid sodium salt) and a non...

journal_title：European journal of pharmacology

authors： Horinouchi T,Koike K

更新日期：1999-07-02 00:00:00

abstract：:The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice. Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner. Pretreatment with inhaled ro...

journal_title：European journal of pharmacology

authors： Kamei J,Hayashi SS,Takahashi Y,Nozaki C

更新日期：2007-07-02 00:00:00

abstract：:Haloperidol increased 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations in the striatum, nucleus accumbens and olfactory tubercle of both drug-naive rats and rats pretreated with haloperidol (10 injections). The increases in metabolite concentrations were greater in all brain regions of the naive rat...

journal_title：European journal of pharmacology

authors： Finlay JM,Jakubovic A,Fu DS,Fibiger HC

更新日期：1987-05-07 00:00:00

abstract：:Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the effects of sirolimus and paclitaxel on cultured human coronary artery smooth muscle and endothelial cell function or cell cycle changes in balloon-injured arterie...

journal_title：European journal of pharmacology

authors： Parry TJ,Brosius R,Thyagarajan R,Carter D,Argentieri D,Falotico R,Siekierka J

更新日期：2005-11-07 00:00:00

abstract：:Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells...

journal_title：European journal of pharmacology

authors： Jean YH,Chen WF,Duh CY,Huang SY,Hsu CH,Lin CS,Sung CS,Chen IM,Wen ZH

更新日期：2008-01-14 00:00:00

abstract：:We studied the effects of the tyrosine kinase inhibitors genistein and tyrphostin and the tyrosine phosphatase inhibitors sodium orthovanadate and phenylarsine oxide on endotoxin-mediated induction of nitric oxide (NO) synthase in rat aorta and its effects on vascular contractility. Genistein (i.p. 10 mg/kg) inhibited...

journal_title：European journal of pharmacology

authors： Duarte J,Ocete MA,Pérez-Vizcaino F,Zarzuelo A,Tamargo J

更新日期：1997-10-29 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

journal_title：European journal of pharmacology

authors： Vlahos R,Bozinovski S

更新日期：2015-07-15 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and L-5-hydroxytryptophan (5-HTP) were studied on the monosynaptic reflex (MSR) and the polysynaptic reflex (PSR) in acute and chronic spinal rats. Radioimmunoassay showed that while chronic spinal transection (for 2 weeks)...

journal_title：European journal of pharmacology

authors： Nagano N,Ono H,Ozawa M,Fukuda H

更新日期：1988-05-10 00:00:00

abstract：:Procaine and procainamide were covalently bound to acryloyl monomers and polymers. The dose-response and time-action parameters of the cardiac antiarrhythmic protection afforded by the prototype drugs and their acryloyl derivatives against chloroform-hypoxia-induced cardiac arrhythmias in unanesthetized mice and epine...

journal_title：European journal of pharmacology

authors： Erker EF,Baker T,Okamoto M,Udenfriend S,Riker WF Jr

更新日期：1985-08-27 00:00:00

abstract：:The administration of the dopamine D-1 receptor antagonist, SCH 23390, but not of the dopamine D-2 receptor antagonist, sulpiride, suppressed the excessive grooming induced by a new environment or by various neuropeptides. In addition, administration of the dopamine D-1 agonist, SK & F 38393, induced excessive groomin...

journal_title：European journal of pharmacology

authors： Van Wimersma Greidanus TB,Maigret C,Torn M,Ronner E,Van der Kracht S,Van der Wee NJ,Versteeg DH

更新日期：1989-12-07 00:00:00

abstract：:Nitric oxide (NO) plays an important role in the cytotoxic activity of macrophages towards tumour cells and microbial pathogens. We investigated whether alteration of intracellular thiol levels modulates the cytotoxic effects of different NO donors and lipopolysaccharide-induced NO in the murine macrophage cell lin J7...

journal_title：European journal of pharmacology

authors： Zamora R,Matthys KE,Herman AG

更新日期：1997-02-19 00:00:00

abstract：:The inflammation and proliferation of vascular smooth muscle cells (VSMCs) are the basic pathological feature of proliferative vascular diseases. Tanshinone ⅡA (Tan ⅡA), which is the most abundant fat-soluble element extracted from Salvia miltiorrhiza, has potent protective effects on the cardiovascular system. Howeve...

journal_title：European journal of pharmacology

authors： Qin Y,Zheng B,Yang GS,Zhou J,Yang HJ,Nie ZY,Wang TR,Zhang XH,Zhao HY,Shi JH,Wen JK

更新日期：2020-08-05 00:00:00

abstract：:To test the hypothesis that the flavonoid compound, fisetin, protects macrophages from lipid accumulation and senescence through regulation of casein kinase 2-interacting protein-1 (CKIP-1)/REGγ (11S regulatory particles, 28 kDa proteasome activator, proteasome activator subunit 3) signaling. RAW264.7 macrophage cells...

journal_title：European journal of pharmacology

authors： Jia Q,Cao H,Shen D,Yan L,Chen C,Xing S

更新日期：2019-12-15 00:00:00

abstract：:N6-2-(4-Aminophenyl)ethyl-adenosine (APNEA, a non-selective agonist of the adenosine A3 receptors), at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiated the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at l...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-05-30 00:00:00

abstract：:Mitochondrial DNA mutations promote hypertensive renal dysfunction, but the molecular mechanism remains unclear. This study compared renal damage between spontaneously hypertensive rats (SHR) and SHR with mitochondrial transfer (t)RNA mutations. To investigate the role of mitochondrial outer membrane voltage-dependent...

journal_title：European journal of pharmacology

authors： Zhu C,Tian L,Yang H,Chen P,Li Y,Liu Y

更新日期：2019-12-15 00:00:00

abstract：:Cerebral vascular reactivity to prostaglandin E2 was investigated in newborn pigs using closed cranial windows. Exogenous prostaglandin E2 is a dilator of pial arterioles that elevates cyclic AMP in cortical cerebrospinal fluid. Pial arterioles are less sensitive to prostaglandin E2 than to the prostacyclin receptor a...

journal_title：European journal of pharmacology

authors： Parfenova H,Leffler CW

更新日期：1995-05-15 00:00:00

abstract：:The pathophysiology of chronic neurodegenerative diseases, as Alzheimer's diseases, has remained inaccessible till recently. But this situation is changing quickly. In the past decades, genes causing familiar forms of the disease have been identified and provided the genetic framework for the emerging amyloid hypothes...

journal_title：European journal of pharmacology

authors： Epis R,Gardoni F,Marcello E,Genazzani A,Canonico PL,Di Luca M

更新日期：2010-01-10 00:00:00

abstract：:Our previous studies demonstrated that light-induced vascular relaxation (photorelaxation) was mediated by a tissue source of nitric oxide that was independent of endothelial nitric oxide synthase (eNOS), but sensitive to inhibitors of soluble guanylate cyclase, extracellular nitric oxide scavengers and possessed the ...

journal_title：European journal of pharmacology

authors： Ng ES,Cheng ZJ,Ellis A,Ding H,Jiang Y,Li Y,Hollenberg MD,Triggle CR

更新日期：2007-04-10 00:00:00

abstract：:Statins have recently been shown to produce anti-cardiac hypertrophic effects via the regulation of small GTPases. However, the effects of statins on G protein-mediated cardiac hypertrophy, which is the main pathway of cardiac hypertrophy, have not yet been studied. We sought to evaluate whether statin treatment direc...

journal_title：European journal of pharmacology

authors： Choi EY,Chang W,Lim S,Song BW,Cha MJ,Kim HJ,Choi E,Jang Y,Chung N,Hwang KC

更新日期：2010-02-10 00:00:00

abstract：:The aim of the present study was to find out the mechanism by which the inflammatory mediator, bradykinin, induces an increase of the cytosolic Ca(2+) concentration ([Ca(2+)](i)) in enteric neurons. For this purpose, ganglia in the isolated submucosa from rat colon were loaded with the Ca(2+)-sensitive dye, fura-2, an...

journal_title：European journal of pharmacology

authors： Rehn M,Diener M

更新日期：2012-04-15 00:00:00

abstract：:Previous studies have shown that repeated injections of acidic saline, given into the lateral gastrocnemius muscle of rats, results in a bilateral reduction in withdrawal threshold to tactile stimulation of the hindpaws. We have now characterised this model of muscoskeletal pain pharmacologically, by evaluating the an...

journal_title：European journal of pharmacology

authors： Nielsen AN,Mathiesen C,Blackburn-Munro G

更新日期：2004-03-08 00:00:00

abstract：:Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...

journal_title：European journal of pharmacology

authors： Dhein S,Pejman P,Krüsemann K

更新日期：2000-06-16 00:00:00

abstract：:It has been well documented that nordihydroguaiaretic acid (NDGA), a phenolic lignan isolated from the creosote bush, Larrea tridentate, has anti-cancer activity in vitro and in vivo. Several mechanisms have been identified that could contribute to these actions, as NDGA directly inhibits metabolic enzymes and recepto...

journal_title：European journal of pharmacology

authors： Li F,Pham JD,Anderson MO,Youngren JF

更新日期：2009-08-15 00:00:00

abstract：:Chlorogenic acid (CA) is one of the active ingredients in some Chinese herbal injections, which may cause allergic reactions in clinic therapy. However, the criterion of test for allergen had not been employed in current Pharmacopeia of United States, European Pharmacopeia, Japanese Pharmacopeia and British Pharmacope...

journal_title：European journal of pharmacology

authors： Xiao GN,Sun QP,Chen HA

更新日期：2013-01-15 00:00:00

abstract：:Two clinically effective anticonvulsants, phenobarbitone and diazepam, protected 5-day old chicks against picrotoxin convulsions without reducing brain GABA-transaminase activity or raising brain GABA concentration. Ethanolamine-O-sulphate and amino-oxyacetic acid, in doses which inhibited GABA-transminase by at least...

journal_title：European journal of pharmacology

authors： Horton RW,Meldrum BS,Sawaya MC,Stephenson JD

更新日期：1976-11-01 00:00:00

abstract：:Previous studies of myocardium have shown that ischemic preconditioning could be mimicked by nitroglycerin through stimulating the release of calcitonin gene-related peptide (CGRP). The present study examined whether nitroglycerin could also provide a preconditioning stimulus in the peripheral vascular bed (the anse i...

journal_title：European journal of pharmacology

authors： Dun Y,Hao YB,Wu YX,Zhang Y,Zhao RR

更新日期：2001-11-02 00:00:00

abstract：:The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspiro...

journal_title：European journal of pharmacology

authors： Söderpalm B,Lundin B,Hjorth S

更新日期：1993-08-03 00:00:00

abstract：:Canine cerebral arterial strips denuded of endothelium responded to nicotine and transmural electrical stimulation with relaxations, which were abolished by NG-nitro-L-arginine and methylene blue. Magnitudes of relaxation did not differ in the arteries contracted with prostaglandin F2alpha and sumatriptan, an effectiv...

journal_title：European journal of pharmacology

authors： Ayajiki K,Fujioka H,Noda K,Okamura T,Toda N

更新日期：2001-05-18 00:00:00

abstract：:Fat tissue plays an important role in the regulation of inflammatory processes. Increased visceral fat has been associated with a higher production of cytokines that triggers a low-grade inflammatory response, which eventually may contribute to the development of insulin resistance. In the present study, we investigat...

journal_title：European journal of pharmacology

authors： Alarcon-Aguilar FJ,Almanza-Perez J,Blancas G,Angeles S,Garcia-Macedo R,Roman R,Cruz M

更新日期：2008-12-03 00:00:00

abstract：:Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes. The liver is an important organ responsible for the development of insulin resistance, and exploring liver glucose metabolism is important to study insulin resistance. We first established the model of insulin resistance in...

journal_title：European journal of pharmacology

authors： Fan X,Tao J,Zhou Y,Hou Y,Wang Y,Gu D,Su Y,Jang Y,Li S

更新日期：2019-01-15 00:00:00