Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration.

abstract：:Studies have shown a cardioprotective role of thyroid hormones (THs) in cardiac remodeling after acute myocardial infarction (MI). However, there is no data in the literature examining the influence of TH administration on the aortic tissue in an animal model of MI. This study aimed to evaluate the effects of thyroid ...

journal_title：European journal of pharmacology

authors： Ortiz VD,de Castro AL,Campos C,Fernandes RO,Bonetto JHP,Siqueira R,Conzatti A,Fernandes TRG,Belló-Klein A,Araujo ASR

更新日期：2016-11-15 00:00:00

abstract：:The effects of an inhibitor of calmodulin, trifluoperazine (TFP), were determined on the electrical activity of cultured cell reaggregates derived from chick embryonic hearts (15-day-old). The cells exhibited naturally occurring slowly rising action potentials (APs) having a maximum rate of rise (+Vmax) of less than 3...

journal_title：European journal of pharmacology

authors： Bkaily G,Sperelakis N,Eldefrawi M

更新日期：1984-10-01 00:00:00

abstract：:The effects of Bay K 8644 and of nifedipine on histamine-induced mechanical and electrical responses were studied in the longitudinal smooth muscle of the ileum and in the taenia coli isolated from the guinea-pig. Nifedipine (10(-9)-10(-7) M) depressed the tonic and phasic components of histamine contraction. Phasic t...

journal_title：European journal of pharmacology

authors： Morel N,Hardy JP,Godfraind T

更新日期：1987-03-03 00:00:00

abstract：:The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibi...

journal_title：European journal of pharmacology

authors： Matsumura Y,Sasaki Y,Shinyama H,Morimoto S

更新日期：1985-11-19 00:00:00

abstract：:The present experiments were devoted to analyzing the mechanisms involved in the captopril-dependent inhibition of human mesangial cell proliferation. Studies were performed in cultured human mesangial cells incubated with captopril, an angiotensin II-converting enzyme inhibitor with antioxidant properties, lisinopril...

journal_title：European journal of pharmacology

authors： Ruiz-Ginés JA,Pérez-Caballero C,O'Valle F,Rodríguez-Puyol M,Rodríguez-Puyol D

更新日期：1997-10-08 00:00:00

abstract：:Since its clinical inception, tamoxifen (TAM) has proved to be a powerful tool in treating estrogen receptor-positive breast cancers while exhibiting manageable side effects. Although TAM was synthesized as an estrogen receptor antagonist, reports have found that a significant fraction of women with estrogen receptor-...

journal_title：European journal of pharmacology

authors： Radin DP,Patel P

更新日期：2016-06-15 00:00:00

abstract：:The activation of adenosine A(2B) receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evidence for an inhibitory effect of benzodiazepines on mast cell mediated symptoms in patients with systemic mast cell activation disease. Therefore, we investigated the e...

journal_title：European journal of pharmacology

authors： Hoffmann K,Xifró RA,Hartweg JL,Spitzlei P,Meis K,Molderings GJ,von Kügelgen I

更新日期：2013-01-30 00:00:00

abstract：:Some conopeptides derived from cone snails act on specific subunits of the NMDA receptor and thus, exert an influence on the dopamine system. In this study, one such conopeptide, conantokin G, was administered i.c.v. in conjunction with methamphetamine, a potent central nervous system stimulant known to cause dopamine...

journal_title：European journal of pharmacology

authors： Bush L,McCabe T,Hanson GR

更新日期：2000-01-03 00:00:00

abstract：:A study was undertaken to ascertain why in the mouse vas deferens excitatory junction potentials facilitate whereas contractions depress during low frequency stimulation. In a set of contraction studies, where a conditioning stimulus was followed 2 s later by a test stimulus, depression in the first phase of contracti...

journal_title：European journal of pharmacology

authors： Karunanithi S,Lavidis NA,Bennett MR

更新日期：1994-08-11 00:00:00

abstract：:A possible cross-competition between vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor; SRIF) and their respective receptors, was investigated at native or recombinant SRIF and VIP/pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. The activity of VIP was e...

journal_title：European journal of pharmacology

authors： Hannon JP,Langenegger D,Waser B,Hoyer D,Reubi JC

更新日期：2001-08-31 00:00:00

abstract：:We investigated the effects of repeated electroconvulsive shock or imipramine treatment on inositol phosphate accumulation and on the reactivity of neurons to metabotropic glutamate (mGlu) receptor agonists in rat hippocampal slices. (1S,3R)-1-carboxycyclopentane-3-acetic acid (1S,3R-ACPD), a nonselective mGlu recepto...

journal_title：European journal of pharmacology

authors： Pilc A,Brański P,Pałucha A,Tokarski K,Bijak M

更新日期：1998-05-15 00:00:00

abstract：:In the present study, the P2Y receptor(s) mediating the effects of the pyrimidines UTP and UDP on phospholipase C activation in the mouse neuroblastoma x rat glioma hybrid cell line NG108-15 was investigated. Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) analysis detected transcripts for the P2Y(6) and P2Y(...

journal_title：European journal of pharmacology

authors： Sak K,Samuel K,Kelve M,Webb TE

更新日期：2001-03-01 00:00:00

abstract：:We investigated the effects of [D-Ala2,D-Leu5]enkephalin (DADLE). [D-Ala2,MePhe4,Gly-ol5]enkephalin (DAGO), [D-Pen2,D-Pen5]enkephalin (DPDPE) (0.01-1 microM) and bremazocine (0.001-0.3 microM) on the electrically evoked release of radiolabelled neurotransmitters and on the dopamine (DA)-stimulated cyclic AMP efflux fr...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Rice KC,Jacobson AE,Van Gelderen JG,Hogenboom F,Heijna MH,Mulder AH

更新日期：1988-09-13 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:Our recent clinical study indicated that etidronate may inhibit the progression of aortic calcification in hemodialysis patients. To determine whether etidronate inhibits aortic calcification in renal failure rats, renal failure was induced by subtotal nephrectomy, in which 5/6 of the kidneys were removed. Significant...

journal_title：European journal of pharmacology

authors： Tamura K,Suzuki Y,Matsushita M,Fujii H,Miyaura C,Aizawa S,Kogo H

更新日期：2007-03-08 00:00:00

abstract：:Clearance of apoptotic cells, so-called efferocytosis, by alveolar macrophages (AMs) is important for lung homeostasis and is impaired in pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease and asthma. Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and ...

journal_title：European journal of pharmacology

authors： Inoue M,Ishibashi Y,Nogawa H,Yasue T

更新日期：2012-02-29 00:00:00

abstract：:The ability of cannabinoid receptor stimulation or blockade to alter catalepsy produced by dopamine D1 and D2 receptor antagonists was studied in rats. The cannabinoid receptor antagonist SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H- pyrazole-3-carboxamidehydrochloride) (0.5 an...

journal_title：European journal of pharmacology

authors： Anderson JJ,Kask AM,Chase TN

更新日期：1996-01-11 00:00:00

abstract：:Quantitative characterization of the kappa opioid receptor in the rabbit ear artery was carried out using three kappa-selective agonist compounds, dynorphin-(1-13), U-69593 and ethylketocyclazocine. Kinetic analysis was performed using the antagonist, MR 2266. Two other in vitro preparations were studied for compariso...

journal_title：European journal of pharmacology

authors： Berzetei IP,Fong A,Yamamura HI,Duckles SP

更新日期：1988-07-14 00:00:00

abstract：:Morphine produces a state dependent learning. The hippocampus is involved in this kind of learning. Gap junctions (GJs) are involved in some of the effects of morphine and exist in different areas of the hippocampus. We investigated the effects of blocking GJ channels of the hippocampal CA1 area, by means of pre-test ...

journal_title：European journal of pharmacology

authors： Beheshti S,Hosseini SA,Noorbakhshnia M,Eivani M

更新日期：2014-12-15 00:00:00

abstract：:The present study was carried out to clarify the role of nonselective cation channels as a Ca2+ entry pathway in the contraction and the increase in [Ca2+]i induced by endothelin- in endothelium-denuded rat thoracic aorta rings, and their suppression by nitric oxide (NO). In Ca2+-free medium, the endothelin-1-induced ...

journal_title：European journal of pharmacology

authors： Zhang XF,Komuro T,Miwa S,Minowa T,Iwamuro Y,Okamoto Y,Ninomiya H,Sawamura T,Masaki T

更新日期：1998-07-10 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:The effects of 4-aminopyridine (4-AP) on basal and glucose-induced insulin secretion and on plasma glucose concentrations were investigated in vivo in intact mice and in mice subjected to surgical adrenalectomy plus chemical sympathectomy induced by 6-hydroxydopamine. In normal intact mice, an i.v. injection of 4-AP, ...

journal_title：European journal of pharmacology

authors： Ahrén B,Leander S,Lundquist I

更新日期：1981-09-11 00:00:00

abstract：:The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of repolarisation instability were evaluated in conscious telemetered dogs. QT duration variability was determined using a beat-to-beat analysis before and after the ...

journal_title：European journal of pharmacology

authors： Schneider J,Hauser R,Andreas JO,Linz K,Jahnel U

更新日期：2005-04-04 00:00:00

abstract：:Luminal exposure of mouse ileal mucosal sheets in vitro to 0.3% Triton X-100 for 10 min resulted in a 45.3 +/- 4.4% decrease in tissue resistance (Rt). Luminal pretreatment of tissue with epidermal growth factor (EGF, 30 nM) reduced the Triton X-100-induced decrease in Rt to 10.2 +/- 3.5%. This effect of luminal EGF w...

journal_title：European journal of pharmacology

authors： Rao R,Porreca F

更新日期：1996-05-15 00:00:00

abstract：:When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 micrograms). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The kappa 1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analges...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Jain S,Wilson R,Pasternak GW

更新日期：1996-08-29 00:00:00

abstract：:Increased motor activity and poor performance in the active avoidance test were observed in the offspring of rats treated with dl-propranolol or sotalol during pregnancy, but not with atenolol and d-propranolol. All substances were administered in drinking water from days 8-22 of gestation. A significant increase in t...

journal_title：European journal of pharmacology

authors： Speiser Z,Gordon I,Rehavi M,Gitter S

更新日期：1991-03-19 00:00:00

abstract：:Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II tria...

journal_title：European journal of pharmacology

authors： Liang X,Yu G,Su R

更新日期：2018-03-15 00:00:00

abstract：:Previously reported work has provided evidence that arylazido aminopropionyl ATP (ANAPP3), a P2-receptor antagonist, blocks the effects of ATP and other purine analogs, in the urinary bladder of the cat. This antagonism appeared limited to those effects mediated by P2-receptors, such as contraction of the urinary blad...

journal_title：European journal of pharmacology

authors： Theobald RJ Jr

更新日期：1986-01-29 00:00:00