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Lack of evidence for cross-competition between vasoactive intestinal peptide and somatostatin at their respective receptors.

Abstract：

:A possible cross-competition between vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor; SRIF) and their respective receptors, was investigated at native or recombinant SRIF and VIP/pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. The activity of VIP was examined in radioligand binding assays at mouse sst(1-5), rat sst(1-2) and human sst(1-5) receptors; or at human tumours preferentially expressing each of the five SRIF receptors. Moreover, SRIF was investigated at human tumoral tissues known to exclusively express specific VIP/PACAP receptor(s). VIP had no significant effect on any of the radioligand binding sites of the SRIF receptor family of rat, mouse or human origin tested. Conversely, SRIF did not interfere with the human VIP/PACAP binding sites tested. Taken together, the results cast reservation on the claimed cross-competition between VIP and SRIF at, specifically human sst(3) receptors, or any of the cloned SRIF or VIP/PACAP receptors recognised to date.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hannon JP,Langenegger D,Waser B,Hoyer D,Reubi JC

doi

10.1016/s0014-2999(01)01223-7

keywords:

subject

Has Abstract

pub_date

2001-08-31 00:00:00

pages

165-73

issue

3

eissn

0014-2999

issn

1879-0712

pii

S0014299901012237

journal_volume

426

pub_type

杂志文章

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