Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors.


UNLABELLED:The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar rats were used after the induction of a chronic acetic acid ulcer. The animals were treated orally for 8 and 15 days, twice daily, with the conventional NSAID, piroxicam (0.35 mg/kg), the non-narcotic analgesic, metamizol (33 mg/kg), the selective cyclooxygenase-2 inhibitor, celecoxib (1.8 mg/kg) and the proton pump inhibitor, omeprazole (0.35 mg/kg). Macroscopic ulcer index, myeloperoxidase activity and prostaglandin E(2) content (both biochemical parameters were evaluated in ulcerated and in intact tissue) as well as histological and immunohistochemical evaluations were carried out at 8 and 15 days. Omeprazole accelerated ulcer healing at 8 and 15 days (P<0.05), while celecoxib delayed healing significantly at 15 days (P<0.01). At 8 days, the prostaglandin E2 content decreased with all NSAIDs at the ulcer site as well as in intact tissue. The same happened at 15 days except for celecoxib, which only diminished prostaglandins in intact mucosa. Immunohistochemistry showed differences in the location of cyclooxygenase-2 and -1. The highest cyclooxygenase-2 expression was found with piroxicam and the lowest expression was with celecoxib. CONCLUSIONS:Down-regulation of cyclooxygenase-2 expression as well as a possible involvement of the chemical structure of celecoxib, a 1,5-dirarylpirazole with a sulphonamide moiety, may account for the delay in ulcer healing.


Eur J Pharmacol


Berenguer B,Alarcón de la Lastra C,Moreno FJ,Martín MJ





Has Abstract


2002-05-03 00:00:00














  • Interaction between halothane and morphine on isolated heart muscle.

    abstract::The present study describes the effects of halothane on morphine activity in the isolated left atria of the rat. Concentration-response curves were obtained for the negative inotropic effects of morphine on electrically stimulated left atria. Morphine significantly decreased the contractile force, with an inhibitory c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Laorden ML,Hernandez J,Carceles MD,Miralles FS,Puig MM

    更新日期:1990-01-17 00:00:00

  • Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists.

    abstract::The coronary vasoconstrictor effect of endothelin-1 was characterized in the isolated rat heart by using the endothelin ETA receptor antagonist D-Asp-L-Pro-D-Val-L-Leu-D-Trp (BQ-123) and the endothelin ETB receptor antagonist [Cys11-Cys15]endothelin-1-(11-21) (IRL 1038). In addition, the involvement of nitric oxide an...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Wang QD,Li XS,Pernow J

    更新日期:1994-12-12 00:00:00

  • Effect of 3-isobutyl-1-methylxanthine and zaprinast on non-adrenergic non-cholinergic relaxation in the rat gastric fundus.

    abstract::Vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) have been proposed as inhibitory non-adrenergic non-cholinergic (NANC) neurotransmitters in the rat gastric fundus. The smooth muscle relaxant actions of VIP and NO are medaited by cAMP and cGMP, respectively; therefore the effect of inhibitors of phosphodi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Barbier AJ,Lefebvre RA

    更新日期:1992-01-21 00:00:00

  • Cobalt(II) β-ketoaminato complexes as novel inhibitors of neuroinflammation.

    abstract::Neuroinflammation contributes to the pathogenesis of neurological disorders including stroke, head trauma, multiple sclerosis, amyotrophic lateral sclerosis as well as age-associated neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Therefore, anti-inflammatory drugs could be used to slow the...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Madeira JM,Beloukhina N,Boudreau K,Boettcher TA,Gurley L,Walker DG,McNeil WS,Klegeris A

    更新日期:2012-02-15 00:00:00

  • The inhibitory effect of opioid and alpha 2-adrenoceptor agonists on cardiac sensory neurones is pertussis toxin-insensitive.

    abstract::The role of pertussis toxin-sensitive G proteins on the alpha 2-adrenoceptor and mu-opioid receptor-mediated inhibition of the efferent function of capsaicin-sensitive neurones was investigated in guinea-pig atria pretreated with guanethidine. In the presence of atropine, CGP 20712A (2-hydroxy-5-(2-[hydroxy-3-(4-[(1-m...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Amerini S,Rubino A,Mantelli L,Filippi S,Ledda F

    更新日期:1992-06-17 00:00:00

  • Characterisation of the non-5-HT3 high-affinity 'R' binding site for (R)-zacopride in brain and other tissues.

    abstract::Previous studies showed that whereas the potent 5-HT3 receptor antagonist (S)-[3H]zacopride only labels 5-HT3 receptor binding sites, the (R)-enantiomer, (R)-[3H]zacopride, labels these receptors and another class of high-affinity binding sites, named the R sites, in membranes from the rat cerebral cortex and NG 108-1...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Kidd FJ,Levy JC,Nielsen M,Hamon M,Gozlan H

    更新日期:1993-09-15 00:00:00

  • Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine.

    abstract::Cocaine interacts with sigma receptors, suggesting that these sites are important for many of its behavioral effects. Therefore, two novel sigma receptor ligands, BD1008 (N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine) and BD1063 (1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine), were evaluat...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: McCracken KA,Bowen WD,Matsumoto RR

    更新日期:1999-01-15 00:00:00

  • Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.

    abstract::We have examined the pharmacology of kainate receptors in cultured hippocampal neurons (6-8 days in vitro (DIV)) from embryonic rats (E17). Cultured neurons were pre-treated with concanavalin A to remove kainate receptor desensitization and whole-cell voltage clamp electrophysiology employed to record inward currents ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Bleakman D,Ogden AM,Ornstein PL,Hoo K

    更新日期:1999-08-13 00:00:00

  • Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo.

    abstract::Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline releas...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Done C,Silverstone P,Sharp T

    更新日期:1992-05-14 00:00:00

  • Diazepam induces tolerance in the isolated skin of Pleurodema thaul.

    abstract::The effects of the long-term administration of diazepam on the potential difference and short-circuit current of the isolated skin of the toad Pleurodema thaul (P. thaul) were investigated. Diazepam applied in a concentration range of 4.6 x 10(-6) to 5.2 x 10(-5) M decreased both electrical parameters. This response w...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Norris B,Contreras E,Nunez G,Contreras G

    更新日期:1995-07-04 00:00:00

  • Tanshinone ⅡA inhibits VSMC inflammation and proliferation in vivo and in vitro by downregulating miR-712-5p expression.

    abstract::The inflammation and proliferation of vascular smooth muscle cells (VSMCs) are the basic pathological feature of proliferative vascular diseases. Tanshinone ⅡA (Tan ⅡA), which is the most abundant fat-soluble element extracted from Salvia miltiorrhiza, has potent protective effects on the cardiovascular system. Howeve...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Qin Y,Zheng B,Yang GS,Zhou J,Yang HJ,Nie ZY,Wang TR,Zhang XH,Zhao HY,Shi JH,Wen JK

    更新日期:2020-08-05 00:00:00

  • Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.

    abstract::Corticotropin-releasing factor (CRF) plays an important role in sympathetic regulation. Centrally administered CRF elevates plasma catecholamine levels, resulting in CRF-dependent hypertension and tachycardia. We previously reported that brain thromboxane A2 mediates CRF-induced elevation of plasma adrenaline levels, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Yamaguchi N,Mimura K,Okada S

    更新日期:2019-11-15 00:00:00

  • Participation by purines in the modulation of norepinephrine release by methoxamine.

    abstract::The alpha 1-receptor agonist methoxamine reduced, by a prazosin sensitive mechanism, the nerve stimulation evoked release of norepinephrine in the rat caudal artery. The effect of methoxamine was also antagonized by the purinoceptor antagonist 8-(p-sulfophenyl)theophylline suggesting an involvement of endogenous purin...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Shinozuka K,Sedaa KO,Bjur RA,Westfall DP

    更新日期:1991-01-17 00:00:00

  • Acute phorbol ester treatment inhibits thapsigargin-induced cell death in porcine aortic smooth muscle cells.

    abstract::We have previously shown that, in porcine aortic smooth muscle cells, endoplasmic reticulum (ER) stressor thapsigargin simultaneously activate the mitochondrial caspase-dependent death cascade and an extracellular signal-regulated kinase (ERK)-dependent pathway, which inhibits the caspase-independent death pathway. Ou...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Lin KC,Liu PS,Peng PY,Chueh SH

    更新日期:2012-07-05 00:00:00

  • Increased Rho-kinase-mediated prostate contractions associated with impairment of β-adrenergic-cAMP-signaling pathway by chronic nitric oxide deficiency.

    abstract::Impairment of nitric oxide (NO) - cyclic GMP signaling pathway is likely to contribute to human begnin prostate hyperplasia (BPH). In the present study we have used a model of chronic NO synthesis inhibition to evaluate the functional alterations of prostate smooth muscle (PSM) machinery, and involvement of Rho-kinase...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Calmasini FB,Leiria LO,Alves Junior MJ,Báu FR,Alexandre EC,Silva FH,Mónica FZ,Antunes E

    更新日期:2015-07-05 00:00:00

  • Propofol facilitates climbing fiber-Purkinje cell synaptic transmission via NMDA receptor in vitro in mice.

    abstract::Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement disorders, including dystonia and ataxia, suggesting that propofol administratio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Zhang XY,Zhang YD,Cui BR,Jin R,Chu CP,Jin XH,Qiu DL

    更新日期:2020-11-15 00:00:00

  • Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition.

    abstract::The aim of this study has been to investigate the antiplatelet activity of a new series of thienylacylhydrazone derivatives analogous to the lead compound LASSBio-294 ((2-thienylidene) 3,4-methylenedioxybenzoylhydrazine). The antiplatelet effect was investigated in rabbit and human platelet rich plasma stimulated by a...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Brito FC,Kummerle AE,Lugnier C,Fraga CA,Barreiro EJ,Miranda AL

    更新日期:2010-07-25 00:00:00

  • The effect of alpha 2-adrenoceptor antagonists in isolated globally ischemic rat hearts.

    abstract::The alpha 2-adrenoceptor antagonist, yohimbine, has been reported to protect hypoxic myocardium. Yohimbine has several other activities, including 5-HT receptor antagonism, at the concentrations at which protection was found. Therefore we designed a study to determine if yohimbine was protecting ischemic myocardium vi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Sargent CA,Dzwonczyk S,Grover GJ

    更新日期:1994-08-11 00:00:00

  • Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.

    abstract::Antiarrhythmic drugs have been considered to be transported by the organic cation transport system. The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Hasannejad H,Takeda M,Narikawa S,Huang XL,Enomoto A,Taki K,Niwa T,Jung SH,Onozato ML,Tojo A,Endou H

    更新日期:2004-09-19 00:00:00

  • Lipopolysaccharide-induced inhibition of gastric acid and pepsin secretion in rats.

    abstract::We used male Wistar rats to determine the effects of lipopolysaccharide (LPS) on gastric secretion. After pylorus ligation, 24-h fasted rats received i.p. injections of different doses of LPS dissolved in sterile saline. The amounts of gastric acid and pepsin secreted were determined 2, 4 or 8 h after injection. Small...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Uehara A,Okumura T,Okamura K,Takasugi Y,Namiki M

    更新日期:1990-05-31 00:00:00

  • Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia.

    abstract::A 5-min period of cerebral ischemia induced in rats by the four-vessel occlusion method increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) assessed by a working memory procedure applied in a three-panel runway task. The protein kinase C (PKC) i...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Ohno M,Yamamoto T,Watanabe S

    更新日期:1991-10-29 00:00:00

  • Studies on the reproductive effects of chronic treatment with agomelatine in the rat.

    abstract::Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproduct...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Canpolat S,Ulker N,Yardimci A,Bulmus O,Ozdemir G,Sahin Z,Ercan Z,Serhatlioglu I,Kacar E,Ozcan M,Turk G,Ozkan Y,Atmaca M,Yilmaz B,Kelestimur H

    更新日期:2016-01-05 00:00:00

  • Direct evidence for an angiotensin AT1 receptor type in rat vas deferens.

    abstract::Physiological experiments suggest that the angiotensin AT1 receptor type predominates in rat vas deferens. Membrane binding experiments, using 125I-[Sarl,Ile8]angiotensin II, confirm the presence of angiotensin AT1 receptors and the absence of angiotensin AT2 receptors in this tissue. Angiotensin II and the angiotensi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Maletínská L,Slaninová J,Kunes J,Zelezná B

    更新日期:1998-06-26 00:00:00

  • Characterization of muscarinic receptors in canine bronchial smooth muscle.

    abstract::Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: O'Rourke ST,Flavahan NA,Vanhoutte PM

    更新日期:1987-08-04 00:00:00

  • The discriminative stimulus properties of cocaine: effects of BAY K 8644 and nimodipine.

    abstract::Calcium channel blockers appear to reduce the cardiac toxicity of cocaine and some stimulant-induced behaviors. The present experiment was designed to test whether the internal state induced by cocaine is altered by the calcium antagonist nimodipine. Substitution tests with the calcium agonist BAY K 8644 were also con...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Callahan PM,Cunningham KA

    更新日期:1990-09-04 00:00:00

  • Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally.

    abstract::We previously reported the synthesis of three new opioid agonists as well as their in vitro and in vivo activity [Girón, R., Abalo, R., Goicoechea, C., Martín, M.I., Callado, L.F., Cano, C., Goya, P., Jagerovic, N. 2002. Synthesis and opioid activity of new fentanyl analogs. Life Sci. 71, 1023-1034]. One of them, N-[1...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Goicoechea C,Sánchez E,Cano C,Jagerovic N,Martín MI

    更新日期:2008-10-24 00:00:00

  • Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation.

    abstract::Intravenous (i.v.) administration of cytidine-5'-diphosphate choline (CDP-choline) (100, 250 and 500 mg/kg) increased blood pressure in normal rats and reversed hypotension in haemorrhagic shock. Choline (54 mg/kg; i.v.), at the dose equimolar to 250 mg/kg CDP-choline decreased blood pressure of rats in both condition...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Savci V,Goktalay G,Cansev M,Cavun S,Yilmaz MS,Ulus IH

    更新日期:2003-05-09 00:00:00

  • In vivo quantification of dopamine D2 receptor parameters in nonhuman primates with [123I]iodobenzofuran and single photon emission computerized tomography.

    abstract::[123I]Iodobenzofuran ([123I]IBF) is a new single photon emission computed tomography (SPECT) tracer for visualization of the dopamine D2 receptors. A tracer constant infusion paradigm was developed to measure the binding potential, density (Bmax) and affinity (KD) of the dopamine D2 receptor in baboons. Three baboons ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Laruelle M,al-Tikriti MS,Zea-Ponce Y,Zoghbi SS,Baldwin RM,Charney DS,Hoffer PB,Kung HF,Innis RB

    更新日期:1994-09-22 00:00:00

  • Study of plasma protein C and inflammatory pathways: biomarkers for dimethylnitrosamine-induced liver fibrosis in rats.

    abstract::The present investigation was designed to identify potential biomarker(s) and assess the involvement of inflammatory pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Following DMN-treatment (10 mg/ml/kg, i.p., given three consecutive days each week for 4 weeks) body and liver weights were significa...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Saha JK,Xia J,Sandusky GE,Chen YF,Gerlitz B,Grinnell B,Jakubowski JA

    更新日期:2007-12-01 00:00:00

  • Effect of hyperosmotic xylitol on gastric secretion in the rat: lack of influence of cyclooxygenase inhibitors.

    abstract::The effects of hyperosmotic solutions of xylitol were tested on acid and bicarbonate outputs from the rat stomach as well as on acid back-diffusion. Hyperosmotic solutions were instilled into anesthetized rats by an esophageal cannula and drained through a duodenal catheter. Spontaneously secreting and histamine-stimu...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章


    authors: Assouline G,Danon A

    更新日期:1984-07-13 00:00:00