Effects of GABA and diazepam on 3H-serotonin release from hippocampal synaptosomes.

abstract：:(5R)-5-hydroxytriptolide (LLDT-8) exhibits strong immunosuppressive activities in vitro and in vivo. Here, we investigated the effects of LLDT-8 on concanavalin A-induced hepatitis. Liver damage was evaluated by serum alanine transaminase (ALT) level and liver histology. The effects of LLDT-8 were determined by measur...

journal_title：European journal of pharmacology

authors： Zhou R,Tang W,Ren YX,He PL,Yang YF,Li YC,Zuo JP

更新日期：2006-05-10 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (OPC-14523) at rat and human serotonin (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. OPC-14523 (1 microM...

journal_title：European journal of pharmacology

authors： Jordan S,Chen R,Koprivica V,Hamilton R,Whitehead RE,Tottori K,Kikuchi T

更新日期：2005-07-11 00:00:00

abstract：:Persistent hyperglycemia increases a systemic oxidative stress, causing the onset of vascular endothelial dysfunction and atherosclerosis. Diallyl trisulfide (DAT), a natural organosulfur compound in garlic, has been reported to have actions of dilating blood vessels and antibacteria, etc. In this study, models of obe...

journal_title：European journal of pharmacology

authors： Liu LL,Yan L,Chen YH,Zeng GH,Zhou Y,Chen HP,Peng WJ,He M,Huang QR

更新日期：2014-02-15 00:00:00

abstract：:Bisphosphonates, which are extensively used in bone-related disorders, have been reported to inhibit atherosclerosis and neointimal hyperplasia. In the present study, we investigated the effects of a bisphosphonate, zoledronate, on the proliferation, adhesion, migration and microstructure of vascular smooth muscle cel...

journal_title：European journal of pharmacology

authors： Wu L,Zhu L,Shi WH,Zhang J,Ma D,Yu B

更新日期：2009-01-05 00:00:00

abstract：:Portulaca oleracea L. is used as a folk medicine in many countries because of its wide range of pharmacological effects. HM-chromanone, isolated from P. oleracea using bioassay-guided fractionation and HPLC, belongs to the homoisoflavonoid group and has been shown to exert several biological effects. In this study, we...

journal_title：European journal of pharmacology

authors： Je JY,Park JE,Seo Y,Han JS

更新日期：2021-02-05 00:00:00

abstract：:The effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-HT) release-inhibitory and anxiolytic-like properties was investigated. The 5-HT release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspiro...

journal_title：European journal of pharmacology

authors： Söderpalm B,Lundin B,Hjorth S

更新日期：1993-08-03 00:00:00

abstract：:Fructose-2,6-bisphosphate is a potent activator of 6-phosphofructo-1-kinase, a key enzyme in glycolysis. We previously revealed that sulfonylureas stimulate fructose-2,6-bisphosphate production in the rat liver by activating 6-phosphofructo-2-kinase. In the present study, we show that CS-045, a new antidiabetic agent,...

journal_title：European journal of pharmacology

authors： Murano K,Inoue Y,Emoto M,Kaku K,Kaneko T

更新日期：1994-03-21 00:00:00

abstract：:Hydroxytyrosol (HT), a polyphenol widely contained as an ester in olive fruits and olive leaves, exhibits a broad spectrum of effectiveness. The present study was designed to investigate the effect of HT alone as well as in the combination with cisplatin on the House Ear Institute-Organ of Corti 1 cells (HEI-OC1) and ...

journal_title：European journal of pharmacology

authors： Zhang W,Man R,Yu X,Yang H,Yang Q,Li J

更新日期：2020-11-15 00:00:00

abstract：:Knockdown of spinal metabotropic glutamate 5 (mGlu5) receptor was shown to inhibit the development of intrathecal morphine antinociceptive tolerance. The present work was designed to evaluate the expression of spinal G-protein during morphine tolerance and knockdown of spinal mGlu5 receptor with antisense oligonucleot...

journal_title：European journal of pharmacology

authors： Chen M,Zhang X,Xu H,Ma X,Jiang W,Xu T

更新日期：2014-01-15 00:00:00

abstract：:[3H]Prostaglandin E2 (PGE2) binding sites were 10-fold enriched from a porcine fundic mucosal homogenate by differential centrifugation and subsequent discontinuous sucrose gradient separation. PGE2 bound with an activation energy of 66 kJ/mol to a single class of sites with an affinity of 1.5 +/- 0.4 nM and a capacit...

journal_title：European journal of pharmacology

authors： Beinborn M,Netz S,Staar U,Sewing KF

更新日期：1988-03-01 00:00:00

abstract：:Sodium nitroprusside produced a dose-dependent increase in extracellular levels of cGMP in the cerebellar cortex in vivo. This was independent of nitric oxide synthase activity. The metalloporphyrins zinc-protoporphyrin-IX, tin-protoporphyrin-IX and zinc-deuteroporphyrin-IX,2,4-bis glycol prevented the increase in cGM...

journal_title：European journal of pharmacology

authors： Luo D,Vincent SR

更新日期：1994-05-17 00:00:00

abstract：:The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a d...

journal_title：European journal of pharmacology

authors： Walentiny DM,Gamage TF,Warner JA,Nguyen TK,Grainger DB,Wiley JL,Vann RE

更新日期：2011-04-10 00:00:00

abstract：:In the presence of thiorphan an 'enkephalinase' inhibitor, bestatin an aminopeptidase inhibitor of bacterial origin potently inhibited the hydrolysis of [3H][Leu5]enkephalin by slices from rat striatum with an IC50 value of about 0.2 microM whereas puromycin was approximately 1000 times less potent on this preparation...

journal_title：European journal of pharmacology

authors： Chaillet P,Marçais-Collado H,Costentin J,Yi CC,De La Baume S,Schwartz JC

更新日期：1983-01-21 00:00:00

abstract：:Choline acetyltransferase activity was measured in rats treated with daily injections of ethanol (0.1 g/kg body wt) and or dexamethasone (1 mg/kg body wt) for 5 consecutive days. Ethanol produced a biphasic reduction of choline acetyltransferase activity in rat cerebral cortex, which at most time points was further de...

journal_title：European journal of pharmacology

authors： Wattanathorn J,Kotchabhakdi N,Casalotti SO,Baldwin BA,Govitrapong P

更新日期：1996-10-10 00:00:00

abstract：:It has been well documented that nordihydroguaiaretic acid (NDGA), a phenolic lignan isolated from the creosote bush, Larrea tridentate, has anti-cancer activity in vitro and in vivo. Several mechanisms have been identified that could contribute to these actions, as NDGA directly inhibits metabolic enzymes and recepto...

journal_title：European journal of pharmacology

authors： Li F,Pham JD,Anderson MO,Youngren JF

更新日期：2009-08-15 00:00:00

abstract：:The present experiments were designed to characterize the mechanisms involved in the corticotropin releasing factor (CRF)-induced activation of central sympatho-adrenomedullary outflow in rats. Intracerebroventricularly (i.c.v.) administered CRF and urocortin (0.5, 1.5 and 3.0 nmol/animal) effectively and dose-depende...

journal_title：European journal of pharmacology

authors： Yokotani K,Murakami Y,Okada S,Hirata M

更新日期：2001-05-11 00:00:00

abstract：:Factor Xa inhibitors reduce stroke in patients with atrial fibrillation. Pulmonary veins (PVs) and the sinoatrial node (SAN) are crucial for genesis of atrial fibrillation. However, the electrophysiological effects of factor Xa inhibitors (edoxaban and rivaroxaban) on PVs and the SAN remain unclear. Conventional micro...

journal_title：European journal of pharmacology

authors： Chang CJ,Cheng CC,Chen YC,Higa S,Huang JH,Chen SA,Chen YJ

更新日期：2018-08-15 00:00:00

abstract：:Bacterial lipopolysaccharide and other immunostimulants induce gene expression of an isoform of nitric oxide synthase (iNOS) in vascular smooth muscle cells. This process is dependent on nuclear factor-kappa B (NF-kappa B) activation. The aim of this study was to investigate whether the NF-kappa B and Akt signaling pa...

journal_title：European journal of pharmacology

authors： Hattori Y,Hattori S,Kasai K

更新日期：2003-11-28 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:The study investigated the effects of dopamine D1-like receptor stimulation on the autonomic nervous system. Fenoldopam (20 microg/kg) was injected i.v. in conscious sinoaortic denervated dogs, that is, surgically deprived of baroreflex pathways. In barodenervated dogs, fenoldopam (20 microg/kg) induced arterial hypot...

journal_title：European journal of pharmacology

authors： Vernejoul F,Damase-Michel C,Montastruc JL,Tran MA

更新日期：2002-05-31 00:00:00

abstract：:Primary cultures of rat cerebellar granule neurons express 5-lipoxygenase, an enzyme from the inflammatory pathway of arachidonic acid. Outside the central nervous system (CNS) 5-lipoxygenase participates in cell proliferation. We hypothesized that 5-lipoxygenase is needed for proliferation of immature cerebellar gran...

journal_title：European journal of pharmacology

authors： Uz T,Manev R,Manev H

更新日期：2001-04-20 00:00:00

abstract：:Pirfenidone recently received FDA approval as one of the first two drugs designed to treat idiopathic pulmonary fibrosis. While the clinical data continues to support the efficacy of pirfenidone, the specific molecular mechanism of action of this drug has not been fully defined. From a chemical perspective the compara...

journal_title：European journal of pharmacology

authors： Haak AJ,Girtman MA,Ali MF,Carmona EM,Limper AH,Tschumperlin DJ

更新日期：2017-09-15 00:00:00

abstract：:The sialogogic effect of SNI-2011, a novel muscarinic receptor agonist, (+/-)-cis-2-methylspilo [1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, was compared with that of pilocarpine hydrochloride in a dose range in which the two muscarinic agonists exhibited approximately similar efficacy in eliciting ...

journal_title：European journal of pharmacology

authors： Masunaga H,Ogawa H,Uematsu Y,Tomizuka T,Yasuda H,Takeshita Y

更新日期：1997-11-19 00:00:00

abstract：:The nicotinic acetylcholine receptors in the rat stomach were characterized by means of a radioligand binding assay with (-)-[3H]nicotine as ligand. Saturation binding studies on the gastric fundus membranes revealed the presence of two binding sites with dissociation constant (KD) values of 3.1 and 289 nM, and maximu...

journal_title：European journal of pharmacology

authors： Nishikawa H,Taniguchi T,Ninomiya H,Fujiwara M

更新日期：1988-01-27 00:00:00

abstract：:1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE, PCT: CN02/00412), a novel thioredoxin reductase inhibitor previously synthesized in our lab, has been demonstrated to inhibit the growth of a variety of human cancer cells and to induce apoptosis. Here we report on the potential molecular mechanism of apopt...

journal_title：European journal of pharmacology

authors： Lan L,Zhao F,Wang Y,Zeng H

更新日期：2007-01-26 00:00:00

abstract：:The present study was an attempt to answer the question whether the local anesthetic [3H]tetracaine labels sodium channels in mouse brain synaptosomes. Binding of [3H]tetracaine had a Kd of 0.19 microM and a Bmax ranging from 3.7 to 5.2 pmol/mg of protein. Local anesthetics other than tetracaine and cocaine-related co...

journal_title：European journal of pharmacology

authors： Reith ME,Kim SS,Lajtha A

更新日期：1987-11-10 00:00:00

abstract：:The effects of RX 781094, a new and potent alpha 2-adrenoceptor antagonist, on locus coeruleus (LC) unit activity were examined. Low doses of RX 781094 produced suppression of spontaneous LC unit activity which could be reversed with yohimbine. The increase in LC firing produced by WB 4101 could also be reversed with ...

journal_title：European journal of pharmacology

authors： Goldstein JM,Knobloch LC,Malick JB

更新日期：1983-07-15 00:00:00

abstract：:A single administration of 40 mg/kg (i.p.) of methamphetamine caused a loss of dopamine transporter in the striatum of albino Swiss (CD-1) mouse for at least 3 weeks. The administration of a single dose of [D-Ala2,D-Leu5]enkephalin (DADLE) (18 mg/kg, i.p.), given at day 14 after the administration of methamphetamine, ...

journal_title：European journal of pharmacology

authors： Tsao LI,Cadet JL,Su TP

更新日期：1999-05-21 00:00:00

abstract：:Disturbances in oxidative metabolism are involved in many acute and chronic diseases, as well as in several other conditions. The objective of the present study was to examine the relationship between the level of intracellular reactive oxygen species in the peripheral blood granulocytes of mice, as evaluated by 2',7'...

journal_title：European journal of pharmacology

authors： Rammal H,Bouayed J,Soulimani R

更新日期：2010-02-10 00:00:00