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The calcium channel agonist, Bay K 8644, inhibits renin release from rat kidney cortical slices.

Abstract：

:The effects of Bay K 8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) -pyridine-5-carboxylate], a calcium channel agonist, on renin release in rat kidney cortical slices were examined. Bay K 8644 produced a dose-related inhibition of renin release in the presence of 15 mM potassium. The inhibitory effect of Bay K 8644 on this release was abolished when calcium was excluded from the incubation medium. Nifedipine exerted a concentration-dependent blocking action on the inhibition of renin release by Bay K 8644. These findings support the proposal that calcium influx into the renin secretory cells is an inhibitory signal for renin release.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Matsumura Y,Sasaki Y,Shinyama H,Morimoto S

doi

10.1016/0014-2999(85)90011-1

subject

Has Abstract

pub_date

1985-11-19 00:00:00

pages

369-72

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90011-1

journal_volume

117

pub_type

杂志文章

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