Abstract:
:Haloperidol increased 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations in the striatum, nucleus accumbens and olfactory tubercle of both drug-naive rats and rats pretreated with haloperidol (10 injections). The increases in metabolite concentrations were greater in all brain regions of the naive rats, suggesting that haloperidol pretreatment resulted in a decreased responsiveness to the drug (tolerance). However, subchronic haloperidol injections also resulted in decreased basal metabolite concentrations in rats killed 48 h after the last injection. While the response of drug-experienced rats to haloperidol was attenuated relative to that of drug-naive rats, this difference could be accounted for entirely by the decreased basal metabolite concentrations that occur after repeated haloperidol injections.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Finlay JM,Jakubovic A,Fu DS,Fibiger HCdoi
10.1016/0014-2999(87)90189-0subject
Has Abstractpub_date
1987-05-07 00:00:00pages
117-21issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(87)90189-0journal_volume
137pub_type
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