The effects of lidoflazine and flunarizine on cerebral reactive hyperemia.

abstract：:Retinal ATP-dependent calcium ion uptake is stimulated by a number of agents, but none are previously reported to be as potent as taurine. We have evaluated the effects of 2-aminoethylmethyl-sulfone (AEMS), thiomorpholine-1,1-dioxide (TMS), and N-methyl-thiomorpholine-1,1-dioxide (M-TMS) on calcium ion uptake. AEMS is...

journal_title：European journal of pharmacology

authors： Liebowitz SM,Lombardini JB,Allen CI

更新日期：1986-01-14 00:00:00

abstract：:The effects of acute treatment with sibutramine on the peripheral sympathetic neurotransmission in vas deferens of young rats were still not evaluated. Therefore, we carried out this study in order to verify the effects of acute sibutramine treatment on the neuronal- and exogenous agonist-induced contractions of the y...

journal_title：European journal of pharmacology

authors： de Souza BP,da Silva ED Jr,Jurkiewicz A,Jurkiewicz NH

更新日期：2014-09-05 00:00:00

abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...

journal_title：European journal of pharmacology

authors： Akerman S,Williamson DJ,Hill RG,Goadsby PJ

更新日期：2001-07-13 00:00:00

abstract：:Statins have recently been shown to produce anti-cardiac hypertrophic effects via the regulation of small GTPases. However, the effects of statins on G protein-mediated cardiac hypertrophy, which is the main pathway of cardiac hypertrophy, have not yet been studied. We sought to evaluate whether statin treatment direc...

journal_title：European journal of pharmacology

authors： Choi EY,Chang W,Lim S,Song BW,Cha MJ,Kim HJ,Choi E,Jang Y,Chung N,Hwang KC

更新日期：2010-02-10 00:00:00

abstract：:We have previously demonstrated that (+)-morphine and (-)-morphine given spinally stereoselectively attenuate the spinally-administered (-)-morphine-produced tail-flick inhibition in the mouse. The phenomenon has been defined as antianalgesia. Present studies were then undertaken to determine if the systemic administr...

journal_title：European journal of pharmacology

authors： Wu HE,Hong JS,Tseng LF

更新日期：2007-10-01 00:00:00

abstract：:We investigated, in murine colon circular muscle, the role of adenosine 5'-triphosphate (ATP) and pituitary adenylate cyclase activating peptide (PACAP) as inhibitory neurotransmitters of the fast component of nerve-evoked inhibitory junction potential (fast IJP). Fast IJP was antagonised by apamin or suramin, abolish...

journal_title：European journal of pharmacology

authors： Serio R,Alessandro M,Zizzo MG,Tamburello MP,Mulè F

更新日期：2003-01-24 00:00:00

abstract：:The beta 1- and beta 2-adrenoceptor agonist and thromboxane A2 (TXA2) antagonist properties of trimetoquinol (TMQ, I) and 1-benzyl substituted TMQ analogues [3'-iodo-4',5'-dimethoxy TMQ, II; 3',5'-diiodo-4'-dimethoxy TMQ, III; 3',4'-dimethoxy-5'-nitro TMQ, IV; 3',4'-dimethoxy-5'-amino TMQ; V; and 3',4'-dimethoxy TMQ, ...

journal_title：European journal of pharmacology

authors： Shams G,Romstedt KJ,Gerhardt MA,Harrold MW,Miller DD,Feller DR

更新日期：1990-08-02 00:00:00

abstract：:The protective action of zinc compounds in Crohn's disease-like inflammatory bowel disease in animals has been shown. A similar action of zinc sulfate on ulcerative colitis has not been defined. The present study aimed to delineate the protective action of zinc sulfate and the pathogenic mechanisms of 2,4-dinitrobenze...

journal_title：European journal of pharmacology

authors： Luk HH,Ko JK,Fung HS,Cho CH

更新日期：2002-05-17 00:00:00

abstract：:In the guinea-pig isolated ileum, beta-(2-thienyl)-gamma-aminobutyric acid (BTG; 100-500 microM) reversibly and competitively (pA2 = 4.3 +/- 0.1) antagonised the baclofen-induced (5-100 microM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice p...

journal_title：European journal of pharmacology

authors： Ong J,Kerr DI,Berthelot P,Vaccher C,Flouquet N,Debaert M

更新日期：1992-10-06 00:00:00

abstract：:5-HT(1A) receptor activation by the very-high-efficacy, selective 5-HT(1A) receptor agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-([(5-methyl-pyridin-2-ylmethyl)-amino]-methyl)piperidin-1-yl]-methanone] was recently discovered to constitute a novel central mechanism of broad-spectrum analgesia that, remarkab...

journal_title：European journal of pharmacology

authors： Bruins Slot LA,Koek W,Tarayre JP,Colpaert FC

更新日期：2003-04-18 00:00:00

abstract：:Acute administration of delta 9-tetrahydrocannabinol (THC) (50 mg/kg) at puberty (35-40 days) significantly (P less than 0.05) reduced Ca2+ ATPase activity in hypothalamic plasma membranes but increased, although not significantly, enzyme activity in hypothalamic tissue obtained from adult mice. In contrast, testicula...

journal_title：European journal of pharmacology

authors： Dalterio SL,Bernard SA,Esquivel CR

更新日期：1987-05-07 00:00:00

abstract：:In human bronchial rings the thromboxane A2 (TxA2) mimetic, U46619, produced cumulative concentration-related contractions up to a maximum of 141 +/- 23% of the response induced by carbachol or acetylcholine. The geometric mean EC50 value was 3.2 X 10(-8) M (95% confidence interval: 1.2, 8.9 X 10(-8) M) (n = 5). Contr...

journal_title：European journal of pharmacology

authors： Armour CL,Johnson PR,Alfredson ML,Black JL

更新日期：1989-06-20 00:00:00

abstract：:Morphine produces a state dependent learning. The hippocampus is involved in this kind of learning. Gap junctions (GJs) are involved in some of the effects of morphine and exist in different areas of the hippocampus. We investigated the effects of blocking GJ channels of the hippocampal CA1 area, by means of pre-test ...

journal_title：European journal of pharmacology

authors： Beheshti S,Hosseini SA,Noorbakhshnia M,Eivani M

更新日期：2014-12-15 00:00:00

abstract：:The neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits expressed in heterologous expression systems assemble into at least two distinct subunit stoichiometries of alpha4beta2 receptor. The (alpha4)2(beta2)3 stoichiometry is about 100-fold more sensitive to acetylcholine than the (alpha4)3(beta2)2 stoi...

journal_title：European journal of pharmacology

authors： Zwart R,Broad LM,Xi Q,Lee M,Moroni M,Bermudez I,Sher E

更新日期：2006-06-06 00:00:00

abstract：:The effects of several slow channel blockers were compared on the normal fast action potentials (APs) and the slow APs of guinea pig Purkinje fibers. In spontaneously-firing Purkinje fibers perfused with normal Tyrode solution, mesudipine (analog of nifedipine) at 10(-7) and 10(-6) M, had no significant effect on the ...

journal_title：European journal of pharmacology

authors： Molyvdas PA,Sperelakis N

更新日期：1983-03-25 00:00:00

abstract：:Troglitazone has recently been introduced in the treatment of Type 2 diabetes. In addition to its anti-diabetic effects it acts as a perixosome proliferator activated receptor-gamma (PPAR-gamma) agonist and has anti-inflammatory properties by inhibiting macrophage tumour necrosis factor-alpha (TNF-alpha) secretion. It...

journal_title：European journal of pharmacology

authors： Beales PE,Liddi R,Giorgini AE,Signore A,Procaccini E,Batchelor K,Pozzilli P

更新日期：1998-09-18 00:00:00

abstract：:The beta-carboline FG7142 is a partial inverse agonist at benzodiazepine receptors. We have shown previously that a single dose of this drug causes an upregulation of cortical beta-adrenoceptor numbers in mouse cerebral cortex. This rise was seen seven days, but not 15-30 min or 24 h after FG7142 administration. We no...

journal_title：European journal of pharmacology

authors： Stanford SC,Taylor SC,Little HJ

更新日期：1987-07-09 00:00:00

abstract：:We have eliminated putative palmitoylation sites in the carboxyl tail of the human dopamine D1 receptor by replacing the two cysteine residues with alanines either separately or together. The wild type and the three mutated dopamine D1 receptors were stably expressed in baby hamster kidney cells and characterized to d...

journal_title：European journal of pharmacology

authors： Jin H,Zastawny R,George SR,O'Dowd BF

更新日期：1997-04-11 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:The Ah receptor (AhR) mediates many, if not all, of the toxic and biological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related halogenated aromatic hydrocarbons. Although wide variations in species sensitivity to these compounds have been observed, numerous biochemical and physiochemical charac...

journal_title：European journal of pharmacology

authors： Bank PA,Yao EF,Phelps CL,Harper PA,Denison MS

更新日期：1992-09-01 00:00:00

abstract：:Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have shown neuroprotective properties in animal models of neurodegenerative d...

journal_title：European journal of pharmacology

authors： Liu W,Li Y,Jalewa J,Saunders-Wood T,Li L,Hölscher C

更新日期：2015-10-15 00:00:00

abstract：:There are conflicting reports on the blood pressure effects of tyrosine. The aim of this study was to establish complete dose-response relationships and to compare the effects of various modes of administration of L-tyrosine in anaesthetised normotensive and spontaneously hypertensive rats. The intravenous injection o...

journal_title：European journal of pharmacology

authors： Ekholm S,Karppanen H

更新日期：1987-11-03 00:00:00

abstract：:Omeprazole, besides suppressing gastric acid, causes delayed gastric emptying, which may be associated with aggravated dyspeptic symptoms. Effects of omeprazole on small intestinal transit are unknown. In this study, we evaluated in mice if (a) omeprazole affects transit of a meal through the stomach and small intesti...

journal_title：European journal of pharmacology

authors： Cowan A,Earnest DL,Ligozio G,Rojavin MA

更新日期：2005-07-04 00:00:00

abstract：:Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation. Therefore, components involved in BMP activation are good targets for the development of anti-osteoporo...

journal_title：European journal of pharmacology

authors： Tang CH,Yang RS,Chien MY,Chen CC,Fu WM

更新日期：2008-01-28 00:00:00

abstract：:The novel antiepileptic drug levetiracetam has been shown to reverse anxiogenic effects of benzodiazepine withdrawal in mice tested in an elevated plus-maze without altering the behaviour of normal mice in this model. This could suggest that the effect of levetiracetam is dependent upon the level of stress/anxiety of ...

journal_title：European journal of pharmacology

authors： Lamberty Y,Falter U,Gower AJ,Klitgaard H

更新日期：2003-05-23 00:00:00

abstract：:The pre- and postsynaptic actions of the calcium entry facilitator Bay K 8644 were investigated in the rat isolated vas deferens. Bay K 8644 had no presynaptic effect on adrenergic neurotransmission in the epididymal portion. Bay K 8644 and alpha 1-adrenoceptor agonists potentiated, and the calcium entry blocker nifed...

journal_title：European journal of pharmacology

authors： Hyland L,Warnock P,Docherty JR

更新日期：1984-09-17 00:00:00

abstract：:The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic pe...

journal_title：European journal of pharmacology

authors： Ozawa Y,Komai C,Sakitama K,Ishikawa M

更新日期：1996-02-29 00:00:00

abstract：:Inactivation of gamma-aminobutric acid (GABA) as a neurotransmitter is mediated by diffusion in the synaptic cleft followed by binding to transporter sites and translocation into the intracellular compartment. The GABA transporters of which four subtypes have been cloned (GAT1-4) are distributed at presynaptic nerve e...

journal_title：European journal of pharmacology

authors： Schousboe A,Larsson OM,Sarup A,White HS

更新日期：2004-10-01 00:00:00

abstract：:Our recent study has shown that the intracerebroventricular administration of d-serine, an endogenous and selective agonist for the glycine site of the N-methyl-d-aspartate receptor, alone or in combination with morphine, leads to the potentiation of antinociception on the tail-flick response. Although there is a vari...

journal_title：European journal of pharmacology

authors： Ito K,Yoshikawa M,Maeda M,Jin XL,Takahashi S,Matsuda M,Tamaki R,Kobayashi H,Suzuki T,Hashimoto A

更新日期：2008-05-31 00:00:00

abstract：:Oxygen free radicals have been involved in the pathophysiology of cerebral ischemia, especially after spontaneous or thrombolytic reperfusion. In this study with rats, we have combined a severe focal ischemic insult (2 h) and a prolonged reperfusion time (7 days) to assess the possible sustained neuroprotective effect...

journal_title：European journal of pharmacology

authors： Salom JB,Pérez-Asensio FJ,Burguete MC,Marín N,Pitarch C,Torregrosa G,Romero FJ,Alborch E

更新日期：2004-07-08 00:00:00