Pitrazepin: a central glycine and GABA antagonist.

abstract：:Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in vivo studies to be at least partly responsible for the drug's...

journal_title：European journal of pharmacology

authors： Abdel-Aziz H,Windeck T,Ploch M,Verspohl EJ

更新日期：2006-01-13 00:00:00

abstract：:Potentiation by neuropeptide Y of serotonin (5-HT)-induced vasoconstriction was investigated in porcine coronary artery. 5-HT caused concentration-dependent contraction through 5-HT2A receptors. Neuropeptide Y (30 nM) significantly increased the 5HT-induced contraction by 16+/-5% in arteries with intact endothelium. R...

journal_title：European journal of pharmacology

authors： Tsurumaki T,Nagai S,Bo X,Toyosato A,Higuchi H

更新日期：2006-08-21 00:00:00

abstract：:As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and G...

journal_title：European journal of pharmacology

authors： Harold C,Wallace T,Friedman R,Gudelsky G,Yamamoto B

更新日期：2000-07-14 00:00:00

abstract：:Our aim in performing this study was to analyze in vivo the cell death mechanism induced by toxic doses of digitalis compounds on guinea-pig cardiomyocytes. We analyzed three study groups of five male guinea pigs each. Guinea pigs were intoxicated under anesthesia with ouabain or digoxin (at a 50-60% lethal dose); the...

journal_title：European journal of pharmacology

authors： Ramirez-Ortega M,Zarco G,Maldonado V,Carrillo JF,Ramos P,Ceballos G,Melendez-Zajgla J,Garcia N,Zazueta C,Chanona J,Suarez J,Pastelin G

更新日期：2007-07-02 00:00:00

abstract：:Apoptosis has received widespread attention for its essential roles in biology, medicine and cancer. We previously found that normal, human papillomavirus (HPV) 16-immortalized and their transformed endocervical cells were increasingly resistant to apoptosis induced by a cancer therapeutic drug. Here, analogously, ano...

journal_title：European journal of pharmacology

authors： Mo B,Pater A

更新日期：2003-04-25 00:00:00

abstract：:Brefelamide is an aromatic amide isolated from Dictyostelium cellular slime molds. We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human astrocytoma cells. The inhibition was associated with reduced phosphorylation of extracellular signal-regulated kinase (ERK). Brefelam...

journal_title：European journal of pharmacology

authors： Honma S,Saito M,Kikuchi H,Saito Y,Oshima Y,Nakahata N,Yoshida M

更新日期：2009-08-15 00:00:00

abstract：:P815, a murine mastocytoma cell line, possesses beta-adrenergic binding sites as assessed by using [3H]dihydroalprenolol (antagonist) and [3H]hydroxybenzylisoproterenol (agonist). The number of binding sites per cell was 29 000 for the agonist and 75 000 for the antagonist, as determined by direct binding assays and i...

journal_title：European journal of pharmacology

authors： Durieu-Trautmann O,Delavier-Klutchko C,Hoebeke J,Strosberg AD

更新日期：1985-01-22 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:The new antisecretory drug, telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno-[3,4 - b][1,5]benzodiazepin-10-one), was investigated for its inhibition of functionally intact muscarinic receptors involved in gastric acid secretion in rabbit fundic glands, perfused mouse stomach in vitro, p...

journal_title：European journal of pharmacology

authors： Eltze M,Gönne S,Riedel R,Schlotke B,Schudt C,Simon WA

更新日期：1985-06-07 00:00:00

abstract：:The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential invol...

journal_title：European journal of pharmacology

authors： Blaschuk OW,Devemy E

更新日期：2009-12-25 00:00:00

abstract：:The uptake and release of 3H-dopamine was studied in slices of corpus striatum and substantia nigra in the presence of nialamide. High potassium triggered the outflow of tritium in both brain structures and this release was potentiated by GABA in a dose related fashion, whereas the spontaneous overflow of radioactivit...

journal_title：European journal of pharmacology

authors： Starr MS

更新日期：1979-01-15 00:00:00

abstract：:Animal studies reveal that diverse environmental stimuli that generate anxiety-like behaviors also induce antinociception; conversely, clinical data show that pain perception is reduced under anxiolysis. This study was conducted to investigate the influence of pharmacologically induced-anxiety on nociception and antin...

journal_title：European journal of pharmacology

authors： Jiménez-Velázquez G,Fernández-Guasti A,López-Muñoz FJ

更新日期：2006-10-10 00:00:00

abstract：:Platycodi Radix is the root of Platycodon grandiflorum and it is widely used in the traditional Oriental medicine as an expectorant for pulmonary diseases and a remedy for respiratory disorders. Platycodin D is the major constituent of triterpene saponins in the root. This study investigates apoptosis by platycodin D ...

journal_title：European journal of pharmacology

authors： Ahn KS,Hahn BS,Kwack K,Lee EB,Kim YS

更新日期：2006-05-10 00:00:00

abstract：:Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical application. The purpose...

journal_title：European journal of pharmacology

authors： Li T,Chen H,Yang Z,Wang W,Wang YT,Zhang LM,Zhao JH,Zhou X,Li YM

更新日期：2014-12-15 00:00:00

abstract：:Mouse GluK5 was expressed in Sf9 insect cells and radiolabelled with [(3)H]-kainate in receptor binding assays (Kd=6.9nM). Western immunoblotting indicated an Sf9 GluK5 band doublet corresponding to the glycosylated (128kDa) and deglycosylated (111kDa) protein, which was identical to the band pattern of native rat bra...

journal_title：European journal of pharmacology

authors： Møllerud S,Kastrup JS,Pickering DS

更新日期：2016-10-05 00:00:00

abstract：:The effects of paxilline, a mycotoxin, on whole-cell outward currents from freshly isolated cells of the rat mesenteric artery were studied. Paxilline inhibited a component of the outward current that was also sensitive to iberiotoxin. Inhibition could be observed at a concentration of 10 nM and complete inhibition of...

journal_title：European journal of pharmacology

authors： Li G,Cheung DW

更新日期：1999-05-07 00:00:00

abstract：:The effect of a leukotriene D(4) receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl(3-dimethyl amino-3-oxo propyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin ...

journal_title：European journal of pharmacology

authors： Gök S,Onal A,Cinar MG,Evinç A

更新日期：1999-12-15 00:00:00

abstract：:In the present study 12 of 13 untreated pigs died of ventricular fibrillation during three 10 min episodes of left anterior descending coronary artery occlusion interrupted by 20 min of reperfusion. The selective beta-adrenoceptor antagonist bevantolol in a dose of 1.5 mg X kg-1, but not 0.5 mg X kg-1, offered nearly ...

journal_title：European journal of pharmacology

authors： Verdouw PD,Van Bremen RH,Verkeste CM,Van der Giessen WJ

更新日期：1985-05-20 00:00:00

abstract：:The actions of 5-hydroxytryptamine have been studied in the chick biventer cervicis nerve--muscle preparation. At concentrations between 2.5 X 10(-3) and 3.7 X 10(-3) M, 5HT produced a transient increase in responses to indirect stimulation, but not to direct stimulation. At higher concentrations, 5HT produced a rever...

journal_title：European journal of pharmacology

authors： Teerapong P,Harvey AL

更新日期：1977-07-15 00:00:00

abstract：:Receptor activation of G-proteins can be measured by agonist-stimulated [35S]GTP gamma S binding in the presence of excess guanosine diphosphate (GDP). To determine whether opioid and cannabinoid receptor-mediated G-protein activation correlate with their receptor densities, this study compared opioid- and cannabinoid...

journal_title：European journal of pharmacology

authors： Sim LJ,Selley DE,Xiao R,Childers SR

更新日期：1996-06-20 00:00:00

abstract：:The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condi...

journal_title：European journal of pharmacology

authors： Widdop RE,Krstew E,Jarrott B

更新日期：1990-08-21 00:00:00

abstract：:There is controversy concerning the inhibitory effect of arginine-vasopressin (AVP) on human platelet adenylate cyclase activity, which putatively involves Gi as the G-protein. To clarify this point, the effects of AVP on human platelet membranes were studied by measuring the activities of the high-affinity GTPase, as...

journal_title：European journal of pharmacology

authors： Vittet D,Mathieu MN,Cantau B,Chevillard C

更新日期：1988-06-10 00:00:00

abstract：:In the present study, the mechanism of relaxant response of nitric oxide precursor, L-arginine, was investigated in goat isolated coronary artery. L-arginine (1 mM) reversed the U-46619 (1 microM)-induced contraction both in endothelium-intact and endothelium-denuded arterial ring preparations. L-arginine analogues, L...

journal_title：European journal of pharmacology

authors： Deka DK,Mishra SK,Raviprakash V

更新日期：2009-05-01 00:00:00

abstract：:Endogenous cannabinoid ligands and cannabinoid CB(1) receptor agonists have been shown to exert potent anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA; N-(2-chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, ...

journal_title：European journal of pharmacology

authors： Luszczki JJ,Czuczwar P,Cioczek-Czuczwar A,Czuczwar SJ

更新日期：2006-10-10 00:00:00

abstract：:We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain cyclooxygenase (COX) (COX-1 for bombesin), thereby eliciting the secretion of both catecholamines (CA) from the adrenal medulla by brain thromboxane A(2)-mediated mechanis...

journal_title：European journal of pharmacology

authors： Tanaka K,Shimizu T,Lu L,Yokotani K

更新日期：2012-03-15 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter synthesized in peripheral tissues by the enzyme cystathionine gamma-lyase (CSE). This gas has been documented to be involved in a wide variety of processes including inflammation and nociception. The aim of the present study was to investigate the role of the peripheral H2S ...

journal_title：European journal of pharmacology

authors： Donatti AF,Araujo RM,Soriano RN,Azevedo LU,Leite-Panissi CA,Branco LG

更新日期：2014-09-05 00:00:00

abstract：:We have investigated the endothelin receptor subtypes mediating contraction in isolated preparations of human saphenous vein. Endothelin-1 (EC50: 17.8 nM), endothelin-3 (EC50: 82.3 nM) and the endothelin ETB receptor-selective agonists, [Ala1,3,11,15]endothelin-1 (EC50: 63 nM) and sarafotoxin S6c (EC50: 0.75 nM) all p...

journal_title：European journal of pharmacology

authors： White DG,Garratt H,Mundin JW,Sumner MJ,Vallance PJ,Watts IS

更新日期：1994-05-23 00:00:00

abstract：:In Parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. In consequence, excessive glutamatergic activity will cause excitotoxicity and oxidative ...

journal_title：European journal of pharmacology

authors： Oster S,Radad K,Scheller D,Hesse M,Balanzew W,Reichmann H,Gille G

更新日期：2014-02-05 00:00:00

abstract：:A single dose of 50 mg chlorimipramine was followed by a rapid and pronounced decrease in [3H]imipramine binding to platelet membranes. Incubation of human platelets or platelet membranes with 25 nM chlorimipramine similarly reduced [3H]imipramine binding. Imipramine, desmethylchlorimipramine, chlorpromazine and some ...

journal_title：European journal of pharmacology

authors： Mellerup ET,Plenge P

更新日期：1986-07-15 00:00:00

abstract：:Neurotrophic and neuroprotective properties of Hsp70 were studied in olfactory cortex slices of hypertensive rats under normal conditions and under influence of autologous blood (blood clot). Under normal conditions, synaptic response in slices depended on Hsp70 amount in medium. Incubation of slices with Hsp70 showed...

journal_title：European journal of pharmacology

authors： Mokrushin AA,Pavlinova LI

更新日期：2012-02-29 00:00:00