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Human saphenous vein contains both endothelin ETA and ETB contractile receptors.

Abstract：

:We have investigated the endothelin receptor subtypes mediating contraction in isolated preparations of human saphenous vein. Endothelin-1 (EC50: 17.8 nM), endothelin-3 (EC50: 82.3 nM) and the endothelin ETB receptor-selective agonists, [Ala1,3,11,15]endothelin-1 (EC50: 63 nM) and sarafotoxin S6c (EC50: 0.75 nM) all produced concentration-dependent contractions of human saphenous vein, although [Ala1,3,11,15]endothelin-1 and sarafotoxin S6c only produced a contraction in approximately 50% of the preparations tested. The endothelin ETA receptor antagonist, BQ123 (D-Val,Leu,D-Trp,D-Asp,Pro; 10 microM), antagonized endothelin-1-induced contractions with an estimated potency (pKB approximately 6.0) which was an order of magnitude lower than reported previously for non-human isolated vascular tissues from other species (pA2 values approximately 7.0). These data suggest that both endothelin ETA and endothelin ETB receptors can mediate vascular smooth muscle contraction in human saphenous vein.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

White DG,Garratt H,Mundin JW,Sumner MJ,Vallance PJ,Watts IS

doi

10.1016/0014-2999(94)90144-9

subject

Has Abstract

pub_date

1994-05-23 00:00:00

pages

307-10

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(94)90144-9

journal_volume

257

pub_type

杂志文章

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