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2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice.

Abstract：

:2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gallily R,Breuer A,Mechoulam R

doi

10.1016/s0014-2999(00)00653-1

keywords:

subject

Has Abstract

pub_date

2000-10-06 00:00:00

pages

R5-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(00)00653-1

journal_volume

406

pub_type

杂志文章

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