Abstract:
:The effects of paxilline, a mycotoxin, on whole-cell outward currents from freshly isolated cells of the rat mesenteric artery were studied. Paxilline inhibited a component of the outward current that was also sensitive to iberiotoxin. Inhibition could be observed at a concentration of 10 nM and complete inhibition of the iberiotoxin-sensitive current was achieved at 300 nM. The inhibition could be described by a single site of interaction with a Ki of 35.7 nM. Paxilline had no effect on the component of the current that was sensitive to 4-aminopyridine. It is concluded that paxilline is a potent inhibitor of large conductance Ca2+ -activated K+ currents in vascular smooth muscle cells.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Li G,Cheung DWdoi
10.1016/s0014-2999(99)00188-0keywords:
subject
Has Abstractpub_date
1999-05-07 00:00:00pages
103-7issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(99)00188-0journal_volume
372pub_type
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journal_title:European journal of pharmacology
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abstract::Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic...
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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