Chlorimipramine--but not imipramine--rapidly reduces [3H]imipramine binding in human platelet membranes.

abstract：:The effect of depletion of catecholamines by tyramine or reserpine on the bradykinin-induced relaxation of the rat duodenum aan rabbit ileum was the object of this study. The relaxation was not affected by catecholamine depletion due to repeated addition of tyramine to the isolated organs from either normal or reserpi...

journal_title：European journal of pharmacology

authors： Ufkes JG,Van der Meer C

更新日期：1975-08-01 00:00:00

abstract：:Brain microvessel endothelial cell monolayers have been shown to be a suitable blood-brain barrier in vitro system to study adrenergic regulation of permeability. We tested adrenergic drugs on bovine brain microvessel endothelial cell monolayer permeability to a biomembrane impermeant molecule, sodium fluorescein. End...

journal_title：European journal of pharmacology

authors： Borges N,Shi F,Azevedo I,Audus KL

更新日期：1994-10-14 00:00:00

abstract：:Pedigreed inbred lines of pigmented mice were compared with albino lines differing at either a single locus or by a chromosomal segment of interest, for their responses to morphine. In either of two tests, behavioral activation or reduction in core temperature, albino mice were aberrant in their responses, demonstrati...

journal_title：European journal of pharmacology

authors： Katz RJ

更新日期：1980-11-21 00:00:00

abstract：:There is some controversy as to whether 5-HT(2C) receptor agonists are anxiogenic or anxiolytic. The effects of the novel 5-HT(2C) receptor agonist, (S)-2-chloro-5-fluoro-indol-1-yl)-1-methyl ethylamine fumarate (RO 60 0175), in three models of anxiety were therefore tested. RO 60 0175 was found to induce hypolocomoti...

journal_title：European journal of pharmacology

authors： Kennett G,Lightowler S,Trail B,Bright F,Bromidge S

更新日期：2000-01-10 00:00:00

abstract：:This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (OPC-14523) at rat and human serotonin (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. OPC-14523 (1 microM...

journal_title：European journal of pharmacology

authors： Jordan S,Chen R,Koprivica V,Hamilton R,Whitehead RE,Tottori K,Kikuchi T

更新日期：2005-07-11 00:00:00

abstract：:Myocardial pH was measured continuously with a micro pH electrode inserted into the left ventricular wall in dogs. Anterior descending coronary flow was reduced to about 1/3 of the original flow by partial occlusion of the coronary artery. Myocardial pH decreased from 7.50--7.60 to 7.06--7.24 after partial occlusion. ...

journal_title：European journal of pharmacology

authors： Abiko Y,Sakai K

更新日期：1980-06-27 00:00:00

abstract：:In the present study, the functional properties of α7 nicotinic acetylcholine receptors (α7 nAChRs) and N-methyl-D-aspartate receptors (NMDARs) endogenously expressed in SH-SY5Y human neuroblastoma cells were characterized in an extracellular-signal regulated kinase (ERK) phosphorylation assay. Both choline and N-meth...

journal_title：European journal of pharmacology

authors： Elnagar MR,Walls AB,Helal GK,Hamada FM,Thomsen MS,Jensen AA

更新日期：2018-05-05 00:00:00

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00

abstract：:The effect of cannabinoid receptor activation and blockade on the propulsive activity in the mouse small intestine was assessed in the present study by measuring the transit of an orally administered, non-absorbable marker. The cannabinoid receptor agonist WIN 55,212-2 (R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl...

journal_title：European journal of pharmacology

authors： Colombo G,Agabio R,Lobina C,Reali R,Gessa GL

更新日期：1998-02-26 00:00:00

abstract：:The localization of neuroleptic receptors was studied in the caudate-putamen (CP) and the zona compacta of the substantia nigra using light microscopic autoradiography of 3H-spiperone binding sites. Lesion of the dopaminergic input to the caudate-putamen produced an increase in receptors in the CP, possibly reflecting...

journal_title：European journal of pharmacology

authors： Murrin LC,Gale K,Kuhar MJ

更新日期：1979-12-07 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:The thromboxane mimetic U46619 (11 alpha,9 alpha-epoxymethano PGH2) increased 45Ca2+ uptake in sheep coronary artery rings. A larger increase occurred in endothelium-denuded than in endothelium-inact rings (increase in 45Ca2+ uptake: endothelium intact = 9.6 +/- 3.8, endothelium-denuded = 33.2 +/- 8.1 nmol g-1), in ag...

journal_title：European journal of pharmacology

authors： Dalen T,Vestereng M,Wadsworth R,Kane K

更新日期：1994-08-03 00:00:00

abstract：:The cocaine analog 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (RTI-55 or beta CIT) has a higher affinity for the dopamine transporter and may be potentially useful in interfering with cocaine's actions in brain. However, imaging studies have demonstrated displacement of tracer doses of [123I]RTI-...

journal_title：European journal of pharmacology

authors： Gatley SJ,Volkow ND,Chen R,Fowler JS,Carroll FI,Kuhar MJ

更新日期：1996-01-25 00:00:00

abstract：:Soluble guanylyl cyclase activity and its stimulation by diethylamineNONOate was measured in aortae from hypertensive TGR(mREN2)27 rats (TGR) and Sprague-Dawley controls. Superoxide dismutase was added in vitro to evaluate the contribution of oxidative breakdown of nitric oxide (NO) by superoxide anions. Expression of...

journal_title：European journal of pharmacology

authors： Jacke K,Witte K,Huser L,Behrends S,Lemmer B

更新日期：2000-09-01 00:00:00

abstract：:Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in...

journal_title：European journal of pharmacology

authors： Bowers MB Jr

更新日期：1984-03-16 00:00:00

abstract：:The involvement of brain monoamines in the mechanism of action of nefopam, a new analgesic, was investigated in rats. The study was designed to evaluate the effect of various means of impairing monoaminergic transmission on nefopam analgesia as measured with the hot plate method. Pretreatment with reserpine (2 mg/kg) ...

journal_title：European journal of pharmacology

authors： Esposito E,Romandini S,Merlo-Pich E,Mennini T,Samanin R

更新日期：1986-09-09 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Despite the impact of this pathology in the population, nowadays there is no specific treatment for this disease, focusing its treatment on risks factors. However, it is imperative the existence of a specific treatment, due to this...

journal_title：European journal of pharmacology

authors： de Jesús Acosta-Cota S,Aguilar-Medina EM,Ramos-Payán R,Rendón Maldonado JG,Romero-Quintana JG,Montes-Avila J,Sarmiento-Sánchez JI,Plazas-Guerrero CG,Vergara-Jiménez MJ,Sánchez-López A,Centurión D,Osuna-Martínez U

更新日期：2019-11-15 00:00:00

abstract：:The effect of A-317491 (5-([(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl)-1,2,4-benzenetricarboxylic acid), a recently described selective P2X3 and P2X(2/3) receptor antagonist, on inflammatory mechanical hyperalgesia was examined. In the rat Freund's complete adjuvant model of inflammatory ...

journal_title：European journal of pharmacology

authors： Wu G,Whiteside GT,Lee G,Nolan S,Niosi M,Pearson MS,Ilyin VI

更新日期：2004-11-03 00:00:00

abstract：:We evaluated roles of kinins in allergen-induced nasal blockage and sneezing, and development of nasal hyperresponsiveness to leukotriene D4 in a Japanese cedar pollen-induced allergic rhinitis model of guinea pigs. Sensitised guinea pigs were repeatedly challenged by pollen inhalation once every week. Neither a brady...

journal_title：European journal of pharmacology

authors： Sugahara S,Nabe T,Mizutani N,Takenaka H,Kohno S

更新日期：2003-08-29 00:00:00

abstract：:We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior. Metrifonate (10-100 mg/kg, orally, p.o.) did not improve the water maze or passive avoidance performance of young intact rats. H...

journal_title：European journal of pharmacology

authors： Riekkinen P Jr,Schmidt B,Stefanski R,Kuitunen J,Riekkinen M

更新日期：1996-08-08 00:00:00

abstract：:In isolated guinea pig bronchi, the influence of ruthenium red, capsazepine and extracellular Ca2+ on capsaicin-induced desensitization was examined to investigate whether this desensitization was mediated via a specific receptor coupled with an ion channel. Pre-exposure of tissues to capsaicin (1, 3 or 10 microM) cau...

journal_title：European journal of pharmacology

authors： Jung YS,Cho TS,Moon CH,Shin HS

更新日期：1998-12-04 00:00:00

abstract：:GABAA and GABAB receptor agonists and antagonists were administered locally in the striatum of intact and kainic acid lesioned rats. (+/-)-Baclofen, a GABAB receptor agonist, significantly decreased the level of extracellular dopamine in the striatum of intact rats. (+/-)-Phaclofen, a GABAB receptor antagonist, increa...

journal_title：European journal of pharmacology

authors： Smolders I,De Klippel N,Sarre S,Ebinger G,Michotte Y

更新日期：1995-09-15 00:00:00

abstract：:Several lines of evidence point to the association of vitamin D deficiency with the different components of metabolic syndrome. Yet, the effect of vitamin D supplementation on metabolic syndrome is not clearly elucidated. Herein, we tested the hypothesis that administration of vitamin D, either alone or in combination...

journal_title：European journal of pharmacology

authors： Mostafa DK,Nasra RA,Zahran N,Ghoneim MT

更新日期：2016-12-05 00:00:00

abstract：:The sialogogic effect of SNI-2011, a novel muscarinic receptor agonist, (+/-)-cis-2-methylspilo [1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, was compared with that of pilocarpine hydrochloride in a dose range in which the two muscarinic agonists exhibited approximately similar efficacy in eliciting ...

journal_title：European journal of pharmacology

authors： Masunaga H,Ogawa H,Uematsu Y,Tomizuka T,Yasuda H,Takeshita Y

更新日期：1997-11-19 00:00:00

abstract：:The response of convergent dorsal horn cells to tonic and phasic noxious heating and to noxious pinching was studied before and after topical application of a solution (30 nmol) of the kappa agonist U-50,488H to the dorsal surface of the spinal cord. U-50,488H depressed the discharge of convergent units evoked by ther...

journal_title：European journal of pharmacology

authors： Hernández A,Paeile C,Pérez H,Pelissier T,Soto-Moyano R

更新日期：1990-09-21 00:00:00

abstract：:The alpha 2-adrenoceptor antagonist, yohimbine, has been reported to protect hypoxic myocardium. Yohimbine has several other activities, including 5-HT receptor antagonism, at the concentrations at which protection was found. Therefore we designed a study to determine if yohimbine was protecting ischemic myocardium vi...

journal_title：European journal of pharmacology

authors： Sargent CA,Dzwonczyk S,Grover GJ

更新日期：1994-08-11 00:00:00

abstract：:LK 204-545 ((+/-)-1-(2-(3-(2-cyano-4-(2-cyclopropyl-methoxy-ethoxy)phenoxy)-2-hydro xy-propyl-amino)-ethyl)-3-(4-hydrxy-phenyl) urea), an antagonist that possesses high beta1-/beta2-selectivity in the rat, and a range of cardio-selective and non-selective beta-adrenoceptor antagonists were examined to compare their ra...

journal_title：European journal of pharmacology

authors： Louis SN,Nero TL,Iakovidis D,Jackman GP,Louis WJ

更新日期：1999-02-19 00:00:00

abstract：:Recent studies suggest that endocannabinoid signaling is modulated by 17β-estradiol (17Eβ) however it is unclear if this applies to the cardiovascular actions of anandamide, a major endocannabinoid. This study examined the in vitro effects of 17Eβ on vasorelaxation to anandamide in myograph-mounted small mesenteric ar...

journal_title：European journal of pharmacology

authors： Ho WS

更新日期：2013-02-15 00:00:00

abstract：:Unexpectedly, it was observed that the P2-purinoceptor antagonist, suramin (10 microM to 1 mM), reversed the muscle paralysis caused by structurally unrelated non-depolarizing relaxants. Suramin competitively reversed the blocking action of pancuronium. Both the pre- and postsynaptic blockade of nicotinic receptors by...

journal_title：European journal of pharmacology

authors： Henning RH,Nelemans A,Scaf AH,Van Eekeren J,Agoston S,Den Hertog A

更新日期：1992-05-27 00:00:00

abstract：:The effect of lidocaine on alpha 1-adrenoceptors in cultured neonatal rat ventricular cardiocytes was studied by binding assay. When the cells were cultured in the presence of lidocaine, the binding of (+/-)-beta-([125I]iodo-4-hydroxyphenyl)-ethyl-aminomethyl-tetralone to the cells increased in a concentration- and ti...

journal_title：European journal of pharmacology

authors： Mizuki T,Kobayashi H,Nakashima Y,Kuroiwa A,Izumi F

更新日期：1995-04-24 00:00:00