Abstract：
:Unexpectedly, it was observed that the P2-purinoceptor antagonist, suramin (10 microM to 1 mM), reversed the muscle paralysis caused by structurally unrelated non-depolarizing relaxants. Suramin competitively reversed the blocking action of pancuronium. Both the pre- and postsynaptic blockade of nicotinic receptors by pancuronium was counteracted, as shown by the action of suramin, using train-of-four stimulation. Suramin did not affect the paralysis caused by the depolarizing relaxant, succinylcholine. The reversal action of suramin was not due to an increase in the acetylcholine concentration in the synaptic cleft, since neither the contraction of preparations partially paralysed by diminished acetylcholine release in the presence of low Ca2+ or high Mg2+ nor acetylcholinesterase activity were affected. Suramin did not affect the reduction in twitch tension caused by adenosine and potentiated the ATP-induced reduction in twitch, indicating that ATP-sensitive receptors are not involved in the reversal action of suramin. Consequently, these results suggest that the action of suramin is due to binding with a site on the acetylcholine receptor also occupied by non-depolarizing relaxants, but different from the site occupied by succinylcholine.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Henning RH,Nelemans A,Scaf AH,Van Eekeren J,Agoston S,Den Hertog Adoi
10.1016/0014-2999(92)90211-lkeywords:
subject
Has Abstractpub_date
1992-05-27 00:00:00pages
73-9issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(92)90211-Ljournal_volume
216pub_type
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journal_title：European journal of pharmacology
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