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Ketamine depression of excitatory and inhibitory cholinergic responses in Aplysia neurons.

Abstract：

:The effects of ketamine on the cholinergic excitatory and inhibitory (Cl component) responses in Aplysia neurons were examined using the iontophoretic application of ACh and the two-microelectrode voltage clamp technique. Ketamine reduced both responses non-competitively to the same extent in a dose-dependent and reversible manner at concentrations between 10(-6) and 10(-3) M, without changing the reversal potentials. These findings suggest that ketamine depresses the cholinergic responses by affecting the gating mechanism at postsynaptic membranes.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ikemoto Y

doi

10.1016/0014-2999(86)90018-x

subject

Has Abstract

pub_date

1986-12-02 00:00:00

pages

97-100

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90018-X

journal_volume

132

pub_type

杂志文章

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