Influence of omega-conotoxin on morphine analgesia and withdrawal syndrome in rats.

abstract：:Drugs known to interact with Na+ channels were compared as antagonists of Ca2+-induced contractions of K+-depolarized taenia preparations from guinea-pig caecum. Tetracaine (apparent pA2 5.3 +/- 0.2), quinidine (5.2 +/- 0.1) quinine (5.1 +/- 0.1), d-propranolol (4.7 +/- 0.1), 1-propranolol (4.7 +/- 0.1), lignocaine (4...

journal_title：European journal of pharmacology

authors： Spedding M,Berg C

更新日期：1985-01-22 00:00:00

abstract：:The present study was conducted with an aim to explore the possible role of naringin against ischemia reperfusion induced-neurobehavioral alterations, oxidative damage, cellular and histopathological alterations in cortex, striatum, hippocampus areas of brain. Male Wistar rats (200-220 g) were subjected to bilateral c...

journal_title：European journal of pharmacology

authors： Gaur V,Aggarwal A,Kumar A

更新日期：2009-08-15 00:00:00

abstract：:Results from lesion studies show that selective damage to the temporal cortex or lateral entorhinal cortex impairs visual memory, whereas damage to the hippocampal region does not affect retention of a visual discrimination task. Major input pathways of the above structures use glutamate as neurotransmitter. The gluta...

journal_title：European journal of pharmacology

authors： Myhrer T,Andersen JM

更新日期：2001-10-12 00:00:00

abstract：:Endothelial dysfunction is associated with a reduced bioavailability of nitric oxide (NO). In this study, the effects of 17β-estradiol supplement on endothelial function were examined in ovariectomized (OVX) rats following long-term inhibition of NO synthases with L-NAME. Female Sprague Dawley rats were ovariectomized...

journal_title：European journal of pharmacology

authors： Shi Y,Leung SWS

更新日期：2020-09-05 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:Long-term treatment with sodium barbital did not alter significantly the responsiveness of the isolated rat vas deferens to noradrenaline. However, three days after barbital withdrawal there was a 4.5-fold increase in the sensitivity and an enhanced maximum response to the neurotransmitter. Pharmacological analysis of...

journal_title：European journal of pharmacology

authors： Saban R,Capaz FR,De Moraes S

更新日期：1982-08-13 00:00:00

abstract：:Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline releas...

journal_title：European journal of pharmacology

authors： Done C,Silverstone P,Sharp T

更新日期：1992-05-14 00:00:00

abstract：:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and ...

journal_title：European journal of pharmacology

authors： Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo S

更新日期：1985-08-27 00:00:00

abstract：:Neuropeptide Y has direct vasoconstrictor actions and potentiates the effects of other vasoconstrictor agents. To find out whether both effects of neuropeptide Y are mediated via the same receptor and intracellular mechanism, the interaction between neuropeptide Y and angiotensin II was studied in rabbit femoral arter...

journal_title：European journal of pharmacology

authors： Cressier F,Criscione L,Hofbauer KG

更新日期：1995-01-05 00:00:00

abstract：:Oxidative stress is proved to be harmful to the vascular endothelial cells which are important in preventing the formation and progression of atheromatous plaque. This study was designed to investigate the protective effect and potential mechanisms of dihydrotestosterone (DHT) against H(2)O(2)-induced apoptosis of hum...

journal_title：European journal of pharmacology

authors： Xu ZR,Hu L,Cheng LF,Qian Y,Yang YM

更新日期：2010-09-25 00:00:00

abstract：:Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle-enclosed Xenopus oocytes. Histamine H1 receptor antagonists, promethazine, dimethindene and chlorpheniramine all decreased cromakalim-induced K+ currents wit...

journal_title：European journal of pharmacology

authors： Sakuta H

更新日期：1994-01-01 00:00:00

abstract：:Rat hearts were perfused at 37 degrees C with three clearly-defined protocols: the Ca2+ paradox, the O2 paradox and with 20 mM caffeine. Each protocol involved an initial priming (stage 1) and a subsequent full activation (stage 2) of the damage system of the sarcolemma. Raising [K+]o from 5.4 to 6.5 mM in the Ca2+ pa...

journal_title：European journal of pharmacology

authors： Harding RJ,Duncan CJ

更新日期：1996-12-05 00:00:00

abstract：:In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependen...

journal_title：European journal of pharmacology

authors： Chand N,Harrison JE,Rooney S,Pillar J,Jakubicki R,Nolan K,Diamantis W,Sofia RD

更新日期：1992-01-28 00:00:00

abstract：:We have described here the changes of the biophysical and pharmacological properties of the sarcolemmal ATP-sensitive K+ channels (KATP) of rat skeletal muscle fibres, occurring from an early postnatal period (5 days) to adulthood (210 days). The age-dependent changes of the mean current of the KATP channel (channel a...

journal_title：European journal of pharmacology

authors： Tricarico D,Petruzzi R,Conte Camerino DC

更新日期：1997-03-05 00:00:00

abstract：:The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) binding to membrane preparations from rat cerebral cortex were studied in the absence of gamma-aminobutyric acid (GABA). Addition of low concentrations (3-10 microM) of propofol to washed mem...

journal_title：European journal of pharmacology

authors： Concas A,Santoro G,Mascia MP,Maciocco E,Dazzi L,Biggio G

更新日期：1994-04-15 00:00:00

abstract：:In the presence of RS-15385-197 to preclude binding to alpha 2-adrenoceptors, [3H]p-aminoclonidine labelled a low affinity high capacity site, (Kd = 127.6 +/- 19.7 nM, Bmax 978 +/- 172 fmol/mg protein) whereas [3H]idazoxan labelled a high affinity low capacity site (Kd = 1.66 +/- 0.28 nM, Bmax 45.3 +/- 11.4 fmol/mg pr...

journal_title：European journal of pharmacology

authors： MacKinnon AC,Stewart M,Olverman HJ,Spedding M,Brown CM

更新日期：1993-02-23 00:00:00

abstract：:In the past decade, a growing bulk of evidence has accumulated to suggest that patients suffering from major depression (MD) present some cognitive disturbances, such as impairment in attention, working memory, and executive function, including cognitive inhibition, problem- and task-planning. If the results of short-...

journal_title：European journal of pharmacology

authors： Marazziti D,Consoli G,Picchetti M,Carlini M,Faravelli L

更新日期：2010-01-10 00:00:00

abstract：:To determine if the presence of an activator of guanylate cyclase alters the depressor response to a selective inhibitor of low Km cyclic GMP (cGMP) phosphodiesterase (PDE), zaprinast (3-30 mg/kg) was given i.v. to conscious, spontaneously hypertensive rats during a steady state of i.v. infusion of sodium nitroprussid...

journal_title：European journal of pharmacology

authors： Dundore RL,Pratt PF,Hallenbeck WD,Wassey ML,Silver PJ,Buchholz RA

更新日期：1990-08-21 00:00:00

abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

journal_title：European journal of pharmacology

authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

更新日期：1992-10-01 00:00:00

abstract：:The effect of potassium on the binding of digoxin or digoxigenin to isolated Na+, K+-ATPase was compared with that of potassium on the positive inotropic action of the agents in guinea-pig hearts. The binding of digoxigenin to the enzyme in vitro was reduced to a greater extent by potassium than was the binding of dig...

journal_title：European journal of pharmacology

authors： Akera T,Wiest SA,Brody TM

更新日期：1979-08-15 00:00:00

abstract：:Recently, we reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats. In the present study, we characterized the r...

journal_title：European journal of pharmacology

authors： Shimizu T,Tanaka K,Hasegawa T,Yokotani K

更新日期：2011-03-11 00:00:00

abstract：:Glucagon-like peptide-2 (GLP-2) is a potent, intestinal-specific trophic hormone. However, the relationship between the dose and timing of GLP-2 administration and these trophic effects is not clear. We investigated the effects of variations in the dose and timing of GLP-2 administration on its intestinal trophic acti...

journal_title：European journal of pharmacology

authors： Kaji T,Tanaka H,Holst JJ,Redstone H,Wallace L,de Heuval E,Sigalet DL

更新日期：2008-10-31 00:00:00

abstract：:The effects of paeoniflorin, a glycoside isolated from the root of Paeonia lactiflora, on ion currents in a mouse neuroblastoma and rat glioma hybrid cell line, NG108-15 were investigated. Paeoniflorin (1-300 microM) reversibly produced an inhibition of L-type voltage-dependent Ca2+ current (I(Ca,L)) in a concentratio...

journal_title：European journal of pharmacology

authors： Tsai TY,Wu SN,Liu YC,Wu AZ,Tsai YC

更新日期：2005-10-31 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

journal_title：European journal of pharmacology

authors： Vlahos R,Bozinovski S

更新日期：2015-07-15 00:00:00

abstract：:Ginsenoside Rg3 (Rg3), one of the bioactive extracts found in ginseng root, was reported to have anti-cancer activity in various cancer models. The anti-proliferation effect of Rg3 on prostate cancer cells has been well reported. To test whether Rg3 has an anti-metastatic effect on prostate cancer, we treated a highly...

journal_title：European journal of pharmacology

authors： Pan XY,Guo H,Han J,Hao F,An Y,Xu Y,Xiaokaiti Y,Pan Y,Li XJ

更新日期：2012-05-15 00:00:00

abstract：:The effects of a potent non-steroidal antiinflammatory drug, indomethacin, on the inflammatory response and lymphocyte proliferation were investigated in adjuvant-arthritic rats. As shown by others, adjuvant produced a time-dependent swelling of the contralateral paw which was maximal within 14 days after administrati...

journal_title：European journal of pharmacology

authors： Seng GF,Benensohn J,Bayer BM

更新日期：1990-03-27 00:00:00

abstract：:Possible changes in noradrenergic function were investigated in rat frontal cerebral cortex after acute treatment (1, 2 h) with the GABAB agonist, baclofen. A single i.p. injection of d,l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (N...

journal_title：European journal of pharmacology

authors： Losada ME

更新日期：1991-05-02 00:00:00

abstract：:Eosinophils and their granular proteins are crucial for combating allergic airway diseases. Eosinophils derived from HL-60 clone 15 (HC15) cells have been established as a feasible alternative cell model for human primary eosinophils. Simvastatin, a cholesterol-lowering agent, has been shown to exhibit anti-inflammato...

journal_title：European journal of pharmacology

authors： Fu CH,Lee TJ,Huang CC,Chang PH,Tsai JW,Chuang LP,Su Pang JH

更新日期：2019-08-05 00:00:00

abstract：:Calcium ions are versatile and universal biological signaling factors that regulate numerous cellular processes ranging from cell fertilization, to neuronal plasticity that underlies learning and memory, to cell death. For these functions to be properly executed, calcium signaling requires precise regulation, and fail...

journal_title：European journal of pharmacology

authors： Chakroborty S,Stutzmann GE

更新日期：2014-09-15 00:00:00

abstract：:Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidep...

journal_title：European journal of pharmacology

authors： Hirao R,Fujita T,Sakai A,Kumamoto E

更新日期：2018-01-15 00:00:00