Abstract:
:Neuropeptide Y has direct vasoconstrictor actions and potentiates the effects of other vasoconstrictor agents. To find out whether both effects of neuropeptide Y are mediated via the same receptor and intracellular mechanism, the interaction between neuropeptide Y and angiotensin II was studied in rabbit femoral arteries. In this preparation, neuropeptide Y, but not its 13-36 fragment, induced constriction. Only neuropeptide Y potentiated the vasoconstrictor response to angiotensin II and the associated rise in inositol-1-phosphate. These potentiating effects of neuropeptide Y were totally prevented by removal of extracellular Ca2+, partially prevented by a Ca(2+)-channel blocker and mimicked by a Ca(2+)-channel activator. Pharmacological modulation of adenylate cyclase had no effect. These results suggest that the direct and indirect vascular effects of neuropeptide Y are mediated via Y1 receptors and depend on the influx of extracellular Ca2+. The rise in inositol-1-phosphate seems to be secondary to an increase in intracellular Ca2+, while modulation of adenylate cyclase is apparently not involved.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Cressier F,Criscione L,Hofbauer KGdoi
10.1016/0014-2999(94)00619-isubject
Has Abstractpub_date
1995-01-05 00:00:00pages
57-65issue
1eissn
0014-2999issn
1879-0712pii
001429999400619Ijournal_volume
272pub_type
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journal_title:European journal of pharmacology
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