Abstract:
:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and phentolamine) or adrenergic neuron blockers (guanethidine and reserpine). These suppressions were not observed with a beta-adrenoceptor antagonist (propranolol), or an anticholinergic agent (atropine methyl nitrate). The rise in the activity of the thymidylate-synthesizing enzymes was closely correlated with the increase in the DNA content of the liver. It is concluded that catecholamine regulates the increase in the activity of thymidylate synthetase and thymidine kinase, which are key enzymes in DNA synthesis in regenerating liver. It is also suggested that sympathetic nerves play an important role in liver regeneration.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo Sdoi
10.1016/0014-2999(85)90380-2subject
Has Abstractpub_date
1985-08-27 00:00:00pages
355-60issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(85)90380-2journal_volume
114pub_type
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