Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy.

Abstract:

:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and phentolamine) or adrenergic neuron blockers (guanethidine and reserpine). These suppressions were not observed with a beta-adrenoceptor antagonist (propranolol), or an anticholinergic agent (atropine methyl nitrate). The rise in the activity of the thymidylate-synthesizing enzymes was closely correlated with the increase in the DNA content of the liver. It is concluded that catecholamine regulates the increase in the activity of thymidylate synthetase and thymidine kinase, which are key enzymes in DNA synthesis in regenerating liver. It is also suggested that sympathetic nerves play an important role in liver regeneration.

journal_name

Eur J Pharmacol

authors

Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo S

doi

10.1016/0014-2999(85)90380-2

subject

Has Abstract

pub_date

1985-08-27 00:00:00

pages

355-60

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90380-2

journal_volume

114

pub_type

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