Brain nuclear factor kappa B is involved in the corticotropin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats.

abstract：:In the present study, the inhibitory effects of hesperetin (HSP) on human cardiac Kv1.5 channels expressed in HEK 293 cells and the ultra-rapid delayed rectifier K(+) current (Ikur) in human atrial myocytes were examined by using the whole-cell configuration of the patch-clamp techniques. We found that hesperetin rapi...

journal_title：European journal of pharmacology

authors： Wang H,Wang HF,Wang C,Chen YF,Ma R,Xiang JZ,Du XL,Tang Q

更新日期：2016-10-15 00:00:00

abstract：:Alzheimer's disease is associated with glial activation and increased levels of the cytokines as well as impaired forebrain cholinergic function. Current therapies focus on enhancing cholinergic function by administrating acetylcholinesterase inhibitors, such as galantamine. Epidemiological results also suggest that a...

journal_title：European journal of pharmacology

authors： Wenk GL,Rosi S,McGann K,Hauss-Wegrzyniak B

更新日期：2002-10-25 00:00:00

abstract：:Na+-H+ exchange inhibitors may reduce myocardial damage after reperfusion. However, their effects on microvascular deterioration are not known. We examined the potency of a novel Na+-H+ exchange inhibitor, SM-20550 [ N-(Aminoiminomethyl)-1,4-dimethyl-1H-indole-2-carboxamide methanesulfonate], and its effects on microv...

journal_title：European journal of pharmacology

authors： Ito Y,Imai S,Ui G,Nakano M,Imai K,Kamiyama H,Naganuma F,Matsui K,Ohashi N,Nagai R

更新日期：1999-06-25 00:00:00

abstract：:Although previous studies have demonstrated that Ginkgo biloba extract has modest effects in the improvement of memory and cognitive function of the Alzheimer's disease patients, the mechanism(s) underlying its beneficial effects remain(s) unclear. In this study, the effect of ginkgolide B, one of the major constituen...

journal_title：European journal of pharmacology

authors： Wang SJ,Chen HH

更新日期：2005-05-09 00:00:00

abstract：:T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK293 cells stably expressing the low voltage-activated Ca(2+) channel sub-unit alpha(1I). These currents were inhibited by the known Ca(2+) channel antagonist mibefradil with an IC(50) close to 1 microM. SB-209712 (1,6,bis¿1-[4-(3-phenylpropyl)piperidinyl]¿hex...

journal_title：European journal of pharmacology

authors： McNaughton NC,Warre R,Cooper DG,Nasir S,Ranson JL,Randall A

更新日期：2000-10-27 00:00:00

abstract：:Mutant alph1 subunits of the GABA(A) receptor were coexpressed in combination with the wild-type beta2 and gamma2 subunits in human embryonic kidney (HEK) 293 cells. The binding properties of various benzodiazepine site ligands were determined by displacement of ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5...

journal_title：European journal of pharmacology

authors： Schaerer MT,Buhr A,Baur R,Sigel E

更新日期：1998-08-07 00:00:00

abstract：:The efficacy of a novel, nonpeptidic, caspase 3/7-selective inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (MMPSI) for reducing ischemic injury in isolated rabbit hearts or cardiomyocytes was evaluated. MMPSI (0.1-10 microM) evoked a concentration-dependent reduction in infarct size (up to 56% vs...

journal_title：European journal of pharmacology

authors： Chapman JG,Magee WP,Stukenbrok HA,Beckius GE,Milici AJ,Tracey WR

更新日期：2002-12-05 00:00:00

abstract：:In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ([1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCL]) and sli...

journal_title：European journal of pharmacology

authors： Smaili SS,Cavalcanti PM,Oshiro ME,Ferreira AT,Jurkiewicz A

更新日期：1998-01-19 00:00:00

abstract：:We investigated the relationship between tension development and the cytosolic free Ca2+ level ([Ca2+]i) on exposure of the endothelium-denuded isolated rat aorta to palmitoyl-L-alpha-lysophosphatidylcholine. Lysophosphatidylcholine concentration-dependently induced a gradual increase in [Ca2+]i. Application of 10(-4)...

journal_title：European journal of pharmacology

authors： Suenaga H,Kamata K

更新日期：1999-08-06 00:00:00

abstract：:Receptor autoradiography was used to examine the distribution of muscarinic cholinoceptors ([3H]QNB), alpha 2-adrenoceptors ([3H]rauwolscine), beta-adrenoceptors ([125I]CYP) and substance P receptors ([125I]BHSP) in rabbit aorta, pulmonary artery, rat aorta, dog aorta, splenic, renal and coronary arteries, bovine aort...

journal_title：European journal of pharmacology

authors： Stephenson JA,Summers RJ

更新日期：1987-01-28 00:00:00

abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

journal_title：European journal of pharmacology

authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

更新日期：1989-07-18 00:00:00

abstract：:Identification of natural products that have antitumor activity is invaluable to the chemoprevention and therapy of cancer. The embryos of lotus (Nelumbo nucifera) seeds are consumed in beverage in some parts of the world for their presumed health-benefiting effects. In this report we studied the effects of neferine, ...

journal_title：European journal of pharmacology

authors： Zhang X,Liu Z,Xu B,Sun Z,Gong Y,Shao C

更新日期：2012-02-29 00:00:00

abstract：:The binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine D2 and 5-HT1A receptors was compared to that of 5-methylurapidil, spiperone, risperidone and other prazosin-related ligands. In addition, cyclazosin was investigated at native and clo...

journal_title：European journal of pharmacology

authors： Giardinà D,Crucianelli M,Melchiorre C,Taddei C,Testa R

更新日期：1995-12-04 00:00:00

abstract：:Cytokines and cytokine-induced nitric oxide (NO) play important roles in inflammatory glomerular diseases, and both platelet-derived growth factor and transforming growth factor-beta inhibit cytokine-induced NO production. In this study, we demonstrated that a selective endothelin ET(A) receptor antagonist, BQ-485 (He...

journal_title：European journal of pharmacology

authors： Hirahashi J,Nakaki T,Hishikawa K,Marumo T,Hayashi M,Saruta T

更新日期：1999-01-15 00:00:00

abstract：:Using 3H-ligands and radioactive microspheres we studied the binding characteristics and the effects on the distribution of carotid arterial blood flow of n-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654). The compound had a Ki value of 32 nM (5-HT: 8 nM) on 5-HT1 but no or very weak affinity for 5-HT2, alpha...

journal_title：European journal of pharmacology

authors： Verdouw PD,Jennewein HM,Mierau J,Saxena PR

更新日期：1985-01-08 00:00:00

abstract：:We show that cisplatin resistance in certain lung cancer cell lines can be reversed through inhibition of mTOR (mammalian Target of Rapamycin). These cell lines appear to possess high levels of phospho-mTOR, phospho-AKT and other growth-related proteins, such as hTERT (human telomerase reverse transcriptase), and Cycl...

journal_title：European journal of pharmacology

authors： Wangpaichitr M,Wu C,You M,Kuo MT,Feun L,Lampidis T,Savaraj N

更新日期：2008-09-04 00:00:00

abstract：:Several structural analogs of mazindol were tested as inhibitors of the uptake of [3H] dopamine in rat neostriatum, of [3H] norepinephrine in rat occipital cortex and of [3H] serotonin in whole rat brain. A rather wide range of potencies was observed but a number of the drugs were even more potent than mazindol as upt...

journal_title：European journal of pharmacology

authors： Heikkila RE,Babington RG,Houlihan WJ

更新日期：1981-05-08 00:00:00

abstract：:In the presence of 3 x 10(-6) M captopril, 5 x 10(-7) M des-Asp-Angiotensin I was found to inhibit the electrically (1 and 2 Hz) induced contraction of the rabbit pulmonary artery but had no significant effect on the noradrenaline-stimulated contraction. 2.8 x 10(-6) M indomethacin and 10(-6) M losartan but not 10(-6)...

journal_title：European journal of pharmacology

authors： Sim MK,Soh KS

更新日期：1995-09-15 00:00:00

abstract：:Cancer remains a major public health problem worldwide and was responsible for 9.6 million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab (Trz) are chemotherapeutic drugs used to treat several types of cancer, including solid and non-solid malignancies. Although these drugs have a signi...

journal_title：European journal of pharmacology

authors： Prathumsap N,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

更新日期：2020-01-05 00:00:00

abstract：:Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties...

journal_title：European journal of pharmacology

authors： Abdolmaleki A,Zahri S,Bayrami A

更新日期：2020-09-05 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.), intravenous (i.v.) and oral (p.o.) administration of trimebutine on the gastric motor inhibition induced by acoustic stress were investigated in fasted dogs fitted with strain-gauge transducers on the antrum and proximal jejunum. Started 40-50 min after the last migrati...

journal_title：European journal of pharmacology

authors： Gué M,Pascaud X,Hondé C,Junien JL,Buéno L

更新日期：1988-01-27 00:00:00

abstract：:The purpose of this study is to clarify involvement ratios between central and peripheral cyclooxygenase (COX)-2 in rat inflammatory pain models, by evaluating celecoxib and [6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl]acetic acid (CIAA) on carrageenan-induced mechanical and thermal hyperalgesia. Celecoxib and CIAA exh...

journal_title：European journal of pharmacology

authors： Okumura T,Sakakibara A,Murata Y,Kita Y

更新日期：2008-01-06 00:00:00

abstract：:Rhein is one of the anthraquinones components of Rheum. It shows excellent clinical efficacy and is widely used in the management of several disease conditions including tumors, inflammation, diabetic nephropathy, and viral infections. In this review, we summarize the recent studies on the pharmacological activities o...

journal_title：European journal of pharmacology

authors： Cheng L,Chen Q,Pi R,Chen J

更新日期：2021-01-27 00:00:00

abstract：:The effect of A-317491 (5-([(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl)-1,2,4-benzenetricarboxylic acid), a recently described selective P2X3 and P2X(2/3) receptor antagonist, on inflammatory mechanical hyperalgesia was examined. In the rat Freund's complete adjuvant model of inflammatory ...

journal_title：European journal of pharmacology

authors： Wu G,Whiteside GT,Lee G,Nolan S,Niosi M,Pearson MS,Ilyin VI

更新日期：2004-11-03 00:00:00

abstract：:The aim of this study was to assess the role of nitric oxide (NO) in lipid peroxidation following 5 min of bilateral carotid occlusion in the Mongolian gerbil. The study consisted of 4 experimental groups (n = 10). Animals were either sham operated, subjected to bilateral carotid occlusion or administered the NO synth...

journal_title：European journal of pharmacology

authors： Caldwell M,O'Neill M,Earley B,Kelly JP,Leonard BE

更新日期：1995-10-16 00:00:00

abstract：:Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by an...

journal_title：European journal of pharmacology

authors： Yajima M,Hosokawa T,Ui M

更新日期：1977-03-07 00:00:00

abstract：:Bronchial and alveolar epithelial cell apoptosis is a vital step in smoke-induced lung injury. We investigated whether and how microRNA (miRNA) Let-7f-1-3p would regulate smoke-induced apoptosis in bronchial and alveolar epithelial cells. Human small airway epithelial cells (HSAEC) and human pulmonary alveolar epithel...

journal_title：European journal of pharmacology

authors： Han Z,Zhu Y,Cui Z,Guo P,Wei A,Meng Q

更新日期：2019-11-05 00:00:00

abstract：:In this study, we have examined the effect of acute and chronic administration of LY 277359, a putative 5-HT3 receptor antagonist, on the number of spontaneously active dopamine cells in the substantia nigra pars compacta (SNC or A9) and ventral tegmental area (VTA or A10). This was accomplished using the standard ext...

journal_title：European journal of pharmacology

authors： Minabe Y,Ashby CR Jr,Wang RY

更新日期：1991-12-17 00:00:00

abstract：:Lipopolysaccharide (LPS) administration in rats induces a characteristic syndrome termed 'sickness behavior', including profound changes on locomotor activity and circulating stress and inflammatory mediators. The aim of the present investigation was to evaluate whether the behavioral and the peripheral biomarker resp...

journal_title：European journal of pharmacology

authors： Bison S,Razzoli M,Arban R,Michielin F,Bertani S,Carboni L

更新日期：2011-07-01 00:00:00

abstract：:Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine's effects on locomotor activity (LMA) and food intake were also evaluated...

journal_title：European journal of pharmacology

authors： Li YW,Langdon S,Pieschl R,Strong T,Wright RN,Rohrbach K,Lelas S,Lodge NJ

更新日期：2014-08-15 00:00:00