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Neurochemical mechanisms and pharmacologic strategies in managing nausea and vomiting related to cyclic vomiting syndrome and other gastrointestinal disorders.

Abstract：

:Nausea and vomiting are common gastrointestinal complaints which could be triggered by stimuli in both the peripheral and central nervous systems. They may be considered as defense mechanisms when threatening toxins/agents enter the gastrointestinal tract or there is excessive retention of gastrointestinal contents due to obstruction. The pathophysiology of nausea and vomiting is complex and much still remains unknown. Therefore, treatments are restricted or ineffective in many cases. Nausea and vomiting with functional etiologies including cyclic vomiting syndrome are challenging in gastroenterology. In this article, we review potential pathways, neurochemical transmitters, and their receptors which are possibly involved in the pathophysiology of nausea and vomiting including the entity cyclic vomiting syndrome.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Bashashati M,McCallum RW

doi

10.1016/j.ejphar.2013.09.075

subject

Has Abstract

pub_date

2014-01-05 00:00:00

pages

79-94

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(13)00773-5

journal_volume

722

pub_type

杂志文章,评审

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