Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice.

Abstract:

:The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunization developed experimental autoimmune orchitis lesions with a significantly lower incidence and severity than did the control mice treated under the same experimental conditions with phosphate buffered saline (PBS). The effects of deoxyspergualin were clearly dose-dependent, and the higher dose of the drug also markedly reduced the degree of delayed type hypersensitivity responses against testicular germ cells. These data suggest that deoxyspergualin may be worthy of consideration for the prevention/treatment of human immunoinflammatory orchitis.

journal_name

Eur J Pharmacol

authors

Ablake M,Itoh M,Kaneko T,Iimura A,Nakamura Y,Meroni P,Nicoletti F

doi

10.1016/s0014-2999(02)02045-9

keywords:

subject

Has Abstract

pub_date

2002-08-23 00:00:00

pages

209-12

issue

2

eissn

0014-2999

issn

1879-0712

pii

S0014299902020459

journal_volume

450

pub_type

杂志文章
  • Cannabidiol administration reduces sublesional cancellous bone loss in rats with severe spinal cord injury.

    abstract::Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2017.05.011

    authors: Li D,Lin Z,Meng Q,Wang K,Wu J,Yan H

    更新日期:2017-08-15 00:00:00

  • Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats.

    abstract::Previous studies show that naringenin promotes insulin sensitivity in fructose-fed rats. This study investigates whether naringenin prevents oxidative events and apoptotic changes triggered in the rat liver by a high fructose diet. Male Wistar rats of body weight 150-180 g were fed either diet containing starch (60% c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2010.07.015

    authors: Kannappan S,Palanisamy N,Anuradha CV

    更新日期:2010-10-25 00:00:00

  • Reduced contractile function after balloon denudation of rat carotid arteries.

    abstract::In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phe...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(94)90610-6

    authors: Antonaccio MJ,Normandin D,Ferrer P

    更新日期:1994-04-11 00:00:00

  • Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries.

    abstract::Inhibitors of phosphodiesterases 3 and 4, the main cyclic AMP (cAMP) degrading enzymes in arteries, may have therapeutic potential in cerebrovascular disorders. We analysed the effects of such phosphodiesterases in guinea pig cerebral arteries with organ bath technique and cyclic nucleotide assays. Guinea pig and huma...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2004.02.038

    authors: Birk S,Edvinsson L,Olesen J,Kruuse C

    更新日期:2004-04-05 00:00:00

  • Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.

    abstract::We have eliminated putative palmitoylation sites in the carboxyl tail of the human dopamine D1 receptor by replacing the two cysteine residues with alanines either separately or together. The wild type and the three mutated dopamine D1 receptors were stably expressed in baby hamster kidney cells and characterized to d...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(97)00059-9

    authors: Jin H,Zastawny R,George SR,O'Dowd BF

    更新日期:1997-04-11 00:00:00

  • Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats.

    abstract::We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deo xy-6,9 alpha- nitriloprostaglandin F1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4h caused a d...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90836-9

    authors: Terawaki T,Takakuwa T,Iguchi S,Wakitani K,Kira H,Okegawa T,Kawasaki A,Masuda Y

    更新日期:1988-07-26 00:00:00

  • Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.

    abstract::The pharmacologic profile of Ib, 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a novel nonpeptide angiotensin AT(1) receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2008.05.007

    authors: Wu J,Wang Q,Guo J,Hu Z,Yin Z,Xu J,Wu X

    更新日期:2008-07-28 00:00:00

  • Antitussive effect of moguisteine on allergic coughs in the guinea pig.

    abstract::The effect of moguisteine, a novel peripherally acting non-narcotic antitussive drug, on allergic coughs was examined in guinea pigs. Male Hartley guinea pigs were actively sensitized to ovalbumin. The number of coughs elicited over 5 min following a 2-min exposure to ovalbumin was counted. Exposure of sensitized guin...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00176-9

    authors: Kamei J,Morita K,Kashiwazaki T,Ohsawa M

    更新日期:1998-04-24 00:00:00

  • 2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils.

    abstract::This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2018.03.037

    authors: Liao HR,Chen IS,Liu FC,Lin SZ,Tseng CP

    更新日期:2018-06-15 00:00:00

  • Autoregulation of acetylcholine release in isolated hippocampal nerve endings.

    abstract::The existence of presynaptic autoreceptors modulating acetylcholine release from central cholinergic nerve endings was investigated by using rat hippocampal synaptosomes in a superfusion system. The presence of exogenous acetylcholine, carbachol or oxotremorine in the superfusion fluid produced a dose-dependent inhibi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(81)90147-3

    authors: Marchi M,Paudice P,Raiteri M

    更新日期:1981-07-17 00:00:00

  • Atrial natriuretic factor and endothelin interactions in control of vascular tone.

    abstract::Endothelin-1 (ET-1) is reported to be the most powerful constrictor of blood vessels known. Atrial natriuretic factor is a potent relaxor of contracted vessels. This study examined the potential interaction between these vasoactive peptides on rabbit aortic rings. ET-1 contracted the rings in a dose-dependent manner w...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)94168-w

    authors: Opgenorth TJ,Novosad EI

    更新日期:1990-12-04 00:00:00

  • Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice.

    abstract::Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca2+-permeable channel. The activation of TRPM2 by H2O2 causes cell death in various types of cells. 5-Fluorouracil (5-FU) is an important anticancer drug, but myelosuppression is one of the most frequent adverse effects. The involvemen...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2020.173671

    authors: Ishibashi M,Ishii M,Yamamoto S,Mori Y,Shimizu S

    更新日期:2021-01-15 00:00:00

  • Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.

    abstract::NTP42 is a novel antagonist of the thromboxane A2 receptor (TP) in development for the treatment of pulmonary arterial hypertension (PAH). Recent studies demonstrated that NTP42 and TP antagonism have a role in alleviating PAH pathophysiology. However, the efficacy of NTP42 when used in combination with existing PAH t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2020.173658

    authors: Mulvaney EP,Reid HM,Bialesova L,Mendes-Ferreira P,Adão R,Brás-Silva C,Kinsella BT

    更新日期:2020-12-15 00:00:00

  • The reversal by oximes and their de oximinomethyl analogues of neuromuscular block produced by soman.

    abstract::A series of oximes and related compounds were assessed for their ability to restore soman-induced neuromuscular block in the isolated diaphragm preparation of the rat, guinea-pig and marmoset. In the rat the bispyridinium oximes HS6, HI6 and HS14 were superior to P2S and all other compounds tested. Conversely, in the ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(83)90164-4

    authors: French MC,Wetherell JR,White PD

    更新日期:1983-08-05 00:00:00

  • Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.

    abstract::Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2015.12.021

    authors: Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

    更新日期:2016-01-15 00:00:00

  • An antiarrhythmic effect of adenosine during myocardial ischaemia and reperfusion.

    abstract::Adenosine (10 micrograms kg-1 min-1, infused into the lumen of the left ventricle) and dipyridamole (0.25 mg kg-1 intravenously, a dose that potentiated markedly the fall in arterial pressure in response to bolus doses of adenosine) each reduced the number of extrasystoles which occurred during the first 30 minutes fo...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90229-4

    authors: Wainwright CL,Parratt JR

    更新日期:1988-01-12 00:00:00

  • (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart.

    abstract::The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(96)00442-6

    authors: Yang HT,Endoh M

    更新日期:1996-10-03 00:00:00

  • Nature of functional tolerance produced by chronic flurazepam treatment in the cat.

    abstract::Cats were treated once daily for 35 days with flurazepam (FZP). Different groups received 2, 5 or 20 mg/kg per day. A fourth group was started at 20 mg/kg per day, then the dose was increased to 30, and finally 40 mg/kg per day. Muscle relaxation, ataxia, and other measures of neurological impairment were used to meas...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(82)90100-5

    authors: Rosenberg HC,Chiu TH

    更新日期:1982-07-16 00:00:00

  • Vasoconstricting effect in rat aorta caused by thaliporphine isolated from the plant Neolitsea konishii K.

    abstract::Thaliporphine (0.1-100 microM) produced sustained, concentration-dependent contraction in isolated rings of rat aorta. Thaliporphine (ED50 = 1.5 +/- 0.5 microM) was less potent than endothelin (ED50 = 3.9 +/- 0.4 nM), but was more potent than Bay K 8644 (ED50 = 5.5 +/- 0.6 microM). Thaliporphine also contracted guinea...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(93)90342-f

    authors: Teng CM,Yu SM,Lee SS,Ko FN,Su MJ,Huang TF

    更新日期:1993-03-16 00:00:00

  • Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.

    abstract::Crocetin, an aglycone of crocin, is found both in the saffron crocus (Crocus starus L.) and in gardenia fruit (Gardenia jasminoides Ellis). We evaluated the protective effects of crocetin against the retinal ischemia induced by 5h unilateral ligation of both the pterygopalatine artery (PPA) and the external carotid ar...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2013.02.007

    authors: Ishizuka F,Shimazawa M,Umigai N,Ogishima H,Nakamura S,Tsuruma K,Hara H

    更新日期:2013-03-05 00:00:00

  • Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes.

    abstract::Tacrine and physostigmine were tested for direct nicotinic actions on Xenopus oocytes microinjected with Torpedo electroplaque membranes. In this preparation, responses to acetylcholine arise 6-8 h after microinjection, due to the incorporation of nicotinic receptors into the plasma membrane by a process not involving...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00793-6

    authors: Cantí C,Bodas E,Marsal J,Solsona C

    更新日期:1998-12-18 00:00:00

  • Long-term benzodiazepine treatment reduces neuronal responsiveness to cholecystokinin: an electrophysiological study in the rat.

    abstract::Acute benzodiazepine administration has been reported to antagonize the effect of cholecystokinin both in the periphery and in the central nervous system. A two-week treatment with either diazepam (5 mg/kg per day) or flurazepam (15 mg/kg per day) markedly reduced the excitatory effect of microiontophoretically applie...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90703-0

    authors: Bouthillier A,De Montigny C

    更新日期:1988-06-22 00:00:00

  • Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors.

    abstract::The targets which mediate the actions of the volatile general anaesthetic isoflurane are unknown. Based on pharmacological studies using GABA(A) receptor antagonists it has recently been suggested that GABA(A) receptors would not mediate the immobilizing action of isoflurane. Using the beta3(N265M) knock-in mouse mode...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2005.04.030

    authors: Lambert S,Arras M,Vogt KE,Rudolph U

    更新日期:2005-05-23 00:00:00

  • Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine.

    abstract::The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine. CM 57373 and dl-fenfluramine administered orally caused a dose-related reductio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90762-5

    authors: Miranda GF,Poggesi E,Bianchetti A,Unkovic J,Samanin R

    更新日期:1988-05-20 00:00:00

  • Timely administration of nisoldipine essential for prevention of myocardial ATP catabolism.

    abstract::Calcium entry blockers can effectively preserve high-energy phosphates in ischemic heart. However, little is known about the optimal timing of drug therapy. The moment of nisoldipine administration in relation to its protective efficacy during ischemia and reperfusion was studied in rat hearts. Nisoldipine (50 nM), gi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(85)90662-4

    authors: De Jong JW

    更新日期:1985-11-26 00:00:00

  • Effect of an antihypertensive hydrazine derivative on Ca2+ current of single frog cardiac cells.

    abstract::The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0922-4106(93)90016-3

    authors: Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

    更新日期:1993-01-15 00:00:00

  • Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.

    abstract::The effects of intra-amygdalar neuropeptide Y infusions were assessed in rats using the social interaction test. Neuropeptide Y administered into the central nucleus of the amygdala did not alter behavior, while injections into the basolateral nucleus of the amygdala produced an increased social interaction time. Furt...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(99)00018-7

    authors: Sajdyk TJ,Vandergriff MG,Gehlert DR

    更新日期:1999-03-05 00:00:00

  • Effect of 5-HT1A and 5-HT2A/2C receptor modulation on neuroleptic-induced vacuous chewing movements.

    abstract::Tardive dyskinesia is a serious motor side effect of chronic neuroleptic therapy. Chronic treatment or rats with neuroleptics leads to the development of abnormal oral movements called vacuous chewing movements. Vacuous chewing movements in rats are widely accepted as an animal model of tardive dyskinesia. Atypical an...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(01)01284-5

    authors: Naidu PS,Kulkarni SK

    更新日期:2001-09-28 00:00:00

  • Dopamine receptor antagonists prevent expression, but not development, of morphine sensitization.

    abstract::The present experiments determined the effects of selective dopamine receptor antagonists on the initiation and expression of sensitization to the locomotor-stimulating effects of morphine in rats. Although both the dopamine D1 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(94)00779-7

    authors: Jeziorski M,White FJ

    更新日期:1995-03-14 00:00:00

  • In vivo characterization of novel full and partial 2-(4-aminophenyl)-N,N-dipropylethylamine dopamine D(2) receptor agonists.

    abstract::Behavioral and biochemical techniques were used to compare the in vivo intrinsic efficacy of two new 2-(4-aminophenyl)-N, N-dipropylethylamine dopamine D(2) receptor agonists, 2-(4-amino-3-trifluoromethylphenyl)-N-N-dipropyl-ethylamine (NBF-203) and 2-(4-amino-3-bromo-5-trifluoromethylphenyl)-N-N-dipropylethylamine (N...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00158-8

    authors: Ahlenius S,Ericson E,Florvall L,Jiménez P,Hillegaart V,Wijkström A

    更新日期:2000-04-14 00:00:00