Abstract:
:The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied. The results showed that C3H/He mice immunized with testicular germ cells and treated daily with either 0.3 or 3 mg/kg body weight deoxyspergualin during days 15-20 post-immunization developed experimental autoimmune orchitis lesions with a significantly lower incidence and severity than did the control mice treated under the same experimental conditions with phosphate buffered saline (PBS). The effects of deoxyspergualin were clearly dose-dependent, and the higher dose of the drug also markedly reduced the degree of delayed type hypersensitivity responses against testicular germ cells. These data suggest that deoxyspergualin may be worthy of consideration for the prevention/treatment of human immunoinflammatory orchitis.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Ablake M,Itoh M,Kaneko T,Iimura A,Nakamura Y,Meroni P,Nicoletti Fdoi
10.1016/s0014-2999(02)02045-9keywords:
subject
Has Abstractpub_date
2002-08-23 00:00:00pages
209-12issue
2eissn
0014-2999issn
1879-0712pii
S0014299902020459journal_volume
450pub_type
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