Abstract:
:The effects of morphine (0.1 mg/kg) and 5-HTP (2 mg/kg) on colonic motility were investigated in dogs fasted for 15-22 h and fitted with two strain gauge transducers on the transverse colon at 8 and 12 cm from the ileo-colonic junction. The effects were compared to those obtained after previous intravenous (i.v.) (0.2 mg/kg) or intracerebroventricular (i.c.v.) (10 micrograms/kg) administration of methysergide. Morphine (0.1 mg/kg) increased the colonic motility index by 475% from 0 to 30 min, this primary transient stimulatory response being followed 30-40 min later by a secondary response lasting 3.2 +/- 0.5 h during which the motility index was also significantly increased. Intravenous injection of 5-HTP (1 mg/kg) produced a delayed (30-40 min) colonic hyperactivity with a 160% increase in the motility index from 1 to 3 h after injection similarly to the secondary response to morphine. This secondary colonic hyperactivity induced by morphine was blocked by both i.v. and i.c.v. methysergide administration--whereas the hyperactivity induced by 5-HTP was not blocked by previous i.v. or i.c.v. administration of methysergide--indicating that the similar effects of morphine and 5-HTP on colonic motility are not caused by the same mechanism. It was concluded that the long-lasting stimulatory effects of morphine on colonic motility in dog are centrally mediated and blocked at this level by 5-HT antagonists.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Bueno L,Fioramonti Jdoi
10.1016/0014-2999(82)90503-9subject
Has Abstractpub_date
1982-08-27 00:00:00pages
147-53issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(82)90503-9journal_volume
82pub_type
杂志文章abstract::Benzodiazepines (BDZs) and non-BDZ sedative-hypnotics are effective for the management of chronic insomnia; however, they are associated with adverse effects such as headache, dizziness, and palpitations. Furthermore, long-term use of these medications is associated with decreased blood pressure (BP) or depressed baro...
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journal_title:European journal of pharmacology
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