JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.

abstract：:Rat pheochromocytoma PC12W cell membranes have previously been shown to exclusively contain the AT2 receptor subtype. The present study extended these binding data and explored the functional expression of these binding sites. Our binding competition studies show a potency series of Ang II = Ang III greater than saral...

journal_title：European journal of pharmacology

authors： Leung KH,Roscoe WA,Smith RD,Timmermans PB,Chiu AT

更新日期：1992-09-01 00:00:00

abstract：:Ketamine, a non-selective inhibitor of NMDA (N-methyl-D-aspartate) channels is used in anesthetic or sub-anesthetic doses to induce analgesia, amnesia, to suppress fear, anxiety and depression. Although the ketamine's effect on memory acquisition is known, its effects on other aspects of memory are controversial. Morr...

journal_title：European journal of pharmacology

authors： Moosavi M,Yadollahi Khales G,Rastegar K,Zarifkar A

更新日期：2012-02-29 00:00:00

abstract：:We have investigated the role of tyrosine kinase in the antiarrhythmic effects of peroxynitrite preconditioning in rat isolated heart by using a tyrosine phosphatase inhibitor, sodium orthovanadate, and tyrosine kinase inhibitors, genistein and tyrphostin. Rat hearts were preconditioned by peroxynitrite administration...

journal_title：European journal of pharmacology

authors： Söylemez S,Demiryürek AT,Kanzik I

更新日期：2003-03-19 00:00:00

abstract：:The effects of intracisternal injections of [Lys8]vasopressin and [Arg8]vasopressin (25, 50, 100, 200 mU/kg) and related compounds oxytocin (25, 50, 100, 200 mU/kg), felypressin (25, 50, 100, 200 mU/kg) and vasotocin (100, 200, 400, 800 ng/kg) on the acute neurogenic pressor responses to afferent vagal stimulation (5,...

journal_title：European journal of pharmacology

authors： Montastruc P,Dang Tran L,Montastruc JL

更新日期：1985-11-19 00:00:00

abstract：:Nitric oxide (NO) has been described to exert various anti-atherogenic actions. However, NO, in some cases, has been shown to stimulate the oxidation of low-density lipoprotein (LDL), which constitute an important triggering event in atherosclerosis. Thus, some NO donors, despite their advantages, might also induce ox...

journal_title：European journal of pharmacology

authors： Jaworski K,Kinard F,Goldstein D,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-08-03 00:00:00

abstract：:Acute noise stress decreased [3H]5-hydroxytryptamine ([3H]5-HT) uptake in synaptosomes from rat hypothalamus, hippocampus and cerebral cortex. The decrease was due to the maximum rate of [3H]5-HT uptake, which peaked 30 min after stress and partly returned to resting values within 4 h, with no changes in affinity (Km ...

journal_title：European journal of pharmacology

authors： Mennini T,Taddei C,Codegoni A,Gobbi M,Garattini S

更新日期：1993-09-14 00:00:00

abstract：:The purpose of this study was to investigate whether the selective angiotensin AT2 receptor ligands, CGP 42112B (Nic-Tyr-(N alpha-benzoyloxycarbonyl-Arg)Lys-His-Pro-Ile-OH) and PD 123319 ((s)-1-[[4-(dimethylamino)-3-methyl-phenyl]methyl]-5-(diphenylacetyl+ ++)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-6-carboxylic...

journal_title：European journal of pharmacology

authors： Macari D,Whitebread S,Cumin F,De Gasparo M,Levens N

更新日期：1994-06-23 00:00:00

abstract：:The vasodepressor actions of the cyclic endoperoxides PGG2 and PGH2 were compared with those of their products PGD2 and PGE2 using anaesthetised normotensive and genetically hypertensive rats. Given into the aortic arch of normotensives PGE2 was approximately 6 times more potent than PGH2 and 11 times more potent tha...

journal_title：European journal of pharmacology

authors： Armstrong JM,Boura AL,Hamberg M,Samuelsson B

更新日期：1976-10-01 00:00:00

abstract：:Crocetin, an aglycone of crocin, is found both in the saffron crocus (Crocus starus L.) and in gardenia fruit (Gardenia jasminoides Ellis). We evaluated the protective effects of crocetin against the retinal ischemia induced by 5h unilateral ligation of both the pterygopalatine artery (PPA) and the external carotid ar...

journal_title：European journal of pharmacology

authors： Ishizuka F,Shimazawa M,Umigai N,Ogishima H,Nakamura S,Tsuruma K,Hara H

更新日期：2013-03-05 00:00:00

abstract：:Selegiline, a therapeutic agent of Parkinson's disease, and its metabolite, desmethylselegiline, were explored for their neuroprotective effects against N-methyl-D-aspartate (NMDA)-induced cell death in rat retina. Morphometric analysis of the retina revealed that an intravitreal injection of NMDA induced a significan...

journal_title：European journal of pharmacology

authors： Takahata K,Katsuki H,Kobayashi Y,Muraoka S,Yoneda F,Kume T,Kashii S,Honda Y,Akaike A

更新日期：2003-01-01 00:00:00

abstract：:Evidence for an analgesic interaction between delta-9-tetrahydrocannabinol (Delta(9)-THC) and morphine was sought using an experimental pain model applied to normal volunteers. The study incorporated a double blinded, four treatment, four period, four sequence, crossover design. Subjects received Delta(9)-THC 5 mg ora...

journal_title：European journal of pharmacology

authors： Roberts JD,Gennings C,Shih M

更新日期：2006-01-13 00:00:00

abstract：:Although the vasorelaxant effects of taurine have been studied in rabbit ear artery, rat isolated aorta and mesenteric artery, its pharmacological properties in other vascular beds and underlying mechanism(s) are still not well clarified. The present study was designed to observe the effects of taurine on the contract...

journal_title：European journal of pharmacology

authors： Niu LG,Zhang MS,Liu Y,Xue WX,Liu DB,Zhang J,Liang YQ

更新日期：2008-02-02 00:00:00

abstract：:This study sought to determine the potential role of nitric oxide (NO) in N-methyl-D-aspartate (NMDA)-stimulated efflux of [14C] gamma-aminobutyric acid (GABA) and [3H]acetylcholine from striatal slices in vitro. In Mg2+-free buffer, NMDA-stimulated [14C]GABA and [3H]acetylcholine release were inhibited by the guanyla...

journal_title：European journal of pharmacology

authors： Hanania T,Johnson KM

更新日期：1998-10-23 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:This report describes the molecular pharmacological properties of LR-B/081 (methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[2'-(1H-tetrazol-5- yl) [1,1'-biphenyl]-4-yl]methyl]-1 (6H)-pyrimidinyl]methyl]- 3-thiophenecarboxilate), a novel non-peptide angiotensin II receptor antagonist. This compound potently displaced [3H]angiote...

journal_title：European journal of pharmacology

authors： Renzetti AR,Criscuoli M,Salimbeni A,Subissi A

更新日期：1995-07-18 00:00:00

abstract：:The effects of amiloride on contraction evoked by perivascular nerve stimulation were studied in a ring preparation of rat mesenteric artery. The contraction evoked by nerve stimulation was abolished by tetrodotoxin or prazosin. Amiloride depressed the nerve-induced contraction concentration dependently. Noradrenaline...

journal_title：European journal of pharmacology

authors： Shimamura K,Zou LB,Moriyama K,Yamamoto K,Sekiguchi F,Sunano S

更新日期：1997-02-05 00:00:00

abstract：:The object of the present paper was to investigate the in vivo pharmacological profile of the dihydropyridine neuropeptide Y Y(1) receptor antagonist 1,4-Dihydro-4-[3-[[[[3-[spiro(indene-4,1'-piperidin-1-yl)]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridine dicarboxylic acid, dimethylester (H 394/84). The ...

journal_title：European journal of pharmacology

authors： Malmström RE,Balmér KC,Weilitz J,Nordlander M,Sjölander M

更新日期：2001-04-20 00:00:00

abstract：:Statins have been demonstrated to elicit a broad range of cellular events resulting in an attenuation of the inflammatory response and enhanced protection to the components of the vessel wall. The present study was designed to examine the effect of pitavastatin on pathways associated with the proinflammatory gene, ear...

journal_title：European journal of pharmacology

authors： Lamon BD,Summers BD,Gotto AM Jr,Hajjar DP

更新日期：2009-03-15 00:00:00

abstract：:Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very importan...

journal_title：European journal of pharmacology

authors： Maggi A,Perez J

更新日期：1984-08-03 00:00:00

abstract：:Nitric oxide can exert either protective or damaging effects on the gastric mucosa. To further explore the role of nitric oxide in the modulation of gastric mucosal defense, the effects of intra-arterial administration of the precursor, L-arginine, on susceptibility of the gastric mucosa to damage induced by topically...

journal_title：European journal of pharmacology

authors： Ferraz JG,Tigley A,Wallace JL

更新日期：1994-07-21 00:00:00

abstract：:WEB 2086, a novel specific platelet activating factor (PAF) antagonist derived from triazolodiazepines, inhibited in a dose-related manner the hypotensive and lethal effect of PAF as well as of E. coli endotoxin in the rat. The hypotension induced by endotoxin (15 mg/kg i.v.) or PAF (30 ng/(kg X min) i.v.) in anaesthe...

journal_title：European journal of pharmacology

authors： Casals-Stenzel J

更新日期：1987-03-17 00:00:00

abstract：:The effects of drugs that inhibit human ether-a-go-go-related gene (HERG) related cardiac potassium channels on the variability of QT duration as a sign of repolarisation instability were evaluated in conscious telemetered dogs. QT duration variability was determined using a beat-to-beat analysis before and after the ...

journal_title：European journal of pharmacology

authors： Schneider J,Hauser R,Andreas JO,Linz K,Jahnel U

更新日期：2005-04-04 00:00:00

abstract：:Inhibitory effects of the saponin fraction and its principal constituents, escins Ia, Ib, IIa, and IIb, from horse chestnuts on gastric emptying were investigated in mice loaded with a non-nutrient or nutrient meal. The saponin fraction and escins Ia-IIb inhibited gastric emptying of a 1.5% carboxymethyl cellulose sod...

journal_title：European journal of pharmacology

authors： Matsuda H,Li Y,Murakami T,Yamahara J,Yoshikawa M

更新日期：1999-03-05 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:Immunopharmacology is one of the most dynamic areas in pharmacology encompassing classical immunosuppressive drugs which reveal completely new clues concerning their mode of action as well as novel molecular biology approaches for treating inflammatory and autoimmune diseases, infections and cancer. This article focus...

journal_title：European journal of pharmacology

authors： Pfeilschifter J,Mühl H

更新日期：1999-06-30 00:00:00

abstract：:The effects of cytosolic ATP on Ca2+-dependent K+ (K(Ca)) channel activation in cultured bovine adrenal chromaffin cells were investigated by using single-channel recording patch-clamp techniques. Application of ATP to the intracellular surface of excised inside-out patches activated K(Ca) channels in a dose-dependent...

journal_title：European journal of pharmacology

authors： Chen C,Houchi H,Tamaki T,Nakaya Y

更新日期：1998-06-05 00:00:00

abstract：:In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systemically the specific NMDA receptor/channel antagonists MK801 and CPP (...

journal_title：European journal of pharmacology

authors： Darlington CL,Smith PF

更新日期：1989-12-19 00:00:00

abstract：:Ifoxetine (CGP 15210 G; (+/-)-bis-[cis-3-hydroxy-4-(2,3-dimethyl-phenoxy)]-piperidine sulfate) prevented the depletion of serotonin (5-HT) induced by H 75/12 and p-chloromethamphetamine in the rat brain, and that caused by endogenously released dopamine after the combined administration of haloperidol and amfonelic ac...

journal_title：European journal of pharmacology

authors： Waldmeier PC,Maître L,Baumann PA,Hauser K,Bischoff S,Bittiger H,Paioni R

更新日期：1986-10-14 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors. Substance P analogs, classified as agonists or antagonists based on their actions on smooth muscle, were tested to determine if they also could act at nicotinic receptors on the pheochromocytoma, P...

journal_title：European journal of pharmacology

authors： Eardley D,McGee R Jr

更新日期：1985-08-07 00:00:00