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Both substance P agonists and antagonists inhibit ion conductance through nicotinic acetylcholine receptors on PC12 cells.

Abstract：

:Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors. Substance P analogs, classified as agonists or antagonists based on their actions on smooth muscle, were tested to determine if they also could act at nicotinic receptors on the pheochromocytoma, PC12. All of the analogs tested, [D-Pro2, D-Trp7,9]SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP, [pGlu5, MePhe8, Sar9]SP-(5-11), and [D-Pro4, D-Trp7,9,10]SP-(4-11), inhibited agonist-induced uptake of 86Rb+ through the nicotinic receptors at concentrations quite similar to those required for action at substance P receptors on smooth muscle. Thus, the chemical modifications in the analogs do not substantially alter their ability to inhibit nicotinic receptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Eardley D,McGee R Jr

doi

10.1016/0014-2999(85)90529-1

subject

Has Abstract

pub_date

1985-08-07 00:00:00

pages

101-4

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90529-1

journal_volume

114

pub_type

杂志文章

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