Participation by purines in the modulation of norepinephrine release by methoxamine.

abstract：:The chick has a practical advantage in the screening process in that chicks require only small quantities of drugs. The chick separation stress paradigm has traditionally been recognized as a valid form of anxiolytic screening. Further, chick behavior involving standing motionless with eyes closed or sitting motionles...

journal_title：European journal of pharmacology

authors： Furuse M

更新日期：2015-09-05 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:The histamine H2-receptor antagonist cimetidine potently inhibited [3H]muscimol and enhanced [3H]flunitrazepam binding in membranes prepared from several brain regions in the rat, including the dorsal raphe nucleus. As further examined in cortical membranes, this effect on both GABA and benzodiazepine binding sites wa...

journal_title：European journal of pharmacology

authors： Lakoski JM,Aghajanian GK,Gallager DW

更新日期：1983-03-25 00:00:00

abstract：:Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement disorders, including dystonia and ataxia, suggesting that propofol administratio...

journal_title：European journal of pharmacology

authors： Zhang XY,Zhang YD,Cui BR,Jin R,Chu CP,Jin XH,Qiu DL

更新日期：2020-11-15 00:00:00

abstract：:The effects of acute or repeated treatment of male albino BKW mice with caerulein, a cholecystokinin octapeptide (CCK-8) agonist, and with devazepide (MK-329) and L-365,260, antagonists at CCKA ('peripheral') and CCKB ('central') receptors respectively, on motor activity and [propionyl-3H]propionylated-CCK-8 ([3H]pCCK...

journal_title：European journal of pharmacology

authors： Vasar E,Stephenson JD,Meldrum BS

更新日期：1991-09-24 00:00:00

abstract：:The selectivity of the potent dopamine D-2 agonist 2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0437) was examined in a series of in vivo and in vitro pharmacological models. In radioligand binding assays, N-0437 showed high potency (Ki = 0.69 nM) and selectivity for D-2 receptors as compared to its potency...

journal_title：European journal of pharmacology

authors： Van der Weide J,De Vries JB,Tepper PG,Krause DN,Dubocovich ML,Horn AS

更新日期：1988-03-01 00:00:00

abstract：:Clomipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes. Since blockade of cardiac human ether-a-go-go-related gene (hERG) channels is an important cause of acquired long QT syndrome, we investigated the acute effects of clomipramine o...

journal_title：European journal of pharmacology

authors： Jo SH,Hong HK,Chong SH,Won KH,Jung SJ,Choe H

更新日期：2008-09-11 00:00:00

abstract：:Recombinant vaccinia viruses harboring the human dopamine D4 receptor cDNA containing two 48 base pair-repeats (D4.2) or the rat dopamine D2 short (D2s) receptor cDNA were used to infect rat-1 fibroblasts. Heterologous expression of both dopamine receptors was demonstrated in binding assays. The affinity constants of ...

journal_title：European journal of pharmacology

authors： Bouvier C,Bunzow JR,Guan HC,Unteutsch A,Civelli O,Grandy DK,Van Tol HH

更新日期：1995-06-23 00:00:00

abstract：:Saturable, high-affinity binding sites for [3H]saxitoxin were identified in equine portal vein smooth muscle membranes. These sites had a dissociation constant of 0.29 nM and a maximal binding capacity of 115 fmol.mg-1 of protein. A similar dissociation constant was obtained with cells prepared from rat portal vein. S...

journal_title：European journal of pharmacology

authors： Mironneau J,Martin C,Arnaudeau S,Jmari K,Rakotoarisoa L,Sayet I,Mironneau C

更新日期：1990-08-10 00:00:00

abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：European journal of pharmacology

authors： He Z,Chen C,Huang L,Liu S,Guo L

更新日期：2008-12-03 00:00:00

abstract：:Striatal neurons in primary culture express a wide variety of adenylate cyclase-coupled receptors, and particularly dopamine (DA) D1 receptors, which are known to induce an increase in cyclic AMP production. To study desensitization of those receptor-mediated responses, neurons were incubated in the presence of satura...

journal_title：European journal of pharmacology

authors： Chneiweiss H,Glowinski J,Premont J

更新日期：1990-10-30 00:00:00

abstract：:Serotonin 1A receptor agonists have attracted much interest recently as potential therapeutic agents for levodopa-induced motor complications, such as dyskinesia and motor fluctuations. The effects of piclozotan (SUN N4057) on a rat model of advanced Parkinson's disease were investigated. Parkinsonian rats, unilateral...

journal_title：European journal of pharmacology

authors： Tani Y,Ogata A,Koyama M,Inoue T

更新日期：2010-12-15 00:00:00

abstract：:To investigate the significance of endogenous, neuroleptic-like gamma-type endorphins and their putative receptors, polyclonal and monoclonal antibodies against gamma-type endorphins, which may bio-inactivate the ligands for the receptors, and monoclonal anti-idiotype antibodies, which presumably bind to the receptors...

journal_title：European journal of pharmacology

authors： Van Ree JM,Wolterink G,Igarashi Y,Vanderschuren L,Wiegant VM,Rust CJ,Bruning HW

更新日期：1995-06-12 00:00:00

abstract：:Stem cells have high potential for cell therapy in regenerative medicine. We previously isolated stem cell types from human amniotic fluid, derived from prenatal amniocentesis. One type, characterized by a fast doubling time, was designated as fast human amniotic stem cells (fHASCs). These cells exhibited high differe...

journal_title：European journal of pharmacology

authors： Romani R,Manni G,Donati C,Pirisinu I,Bernacchioni C,Gargaro M,Pirro M,Calvitti M,Bagaglia F,Sahebkar A,Clerici G,Matino D,Pomili G,Di Renzo GC,Talesa VN,Puccetti P,Fallarino F

更新日期：2018-08-15 00:00:00

abstract：:Phenylethylamine (PEA) has been implicated in a number of central and peripheral nervous system disorders. Its possible mechanisms of action include stimulation via catecholamine release and direct stimulation by PEA. We have examined the effects of PEA on isolated vascular smooth muscle (VSM) to further explore the m...

journal_title：European journal of pharmacology

authors： Hansen TR,Greenberg J,Mosnaim AD

更新日期：1980-05-02 00:00:00

abstract：:Taurine influx in the perfused rat heart was characterized and the effect of isoproterenol on this process determined. Hearts were perfused by the Langendorff technique with [3H]-taurine in a non-recirculating system. The rate of taurine influx was constant for at least 20 min and the process was saturable. A Km of 45...

journal_title：European journal of pharmacology

authors： Chubb J,Huxtable R

更新日期：1978-04-15 00:00:00

abstract：:The ability of the conotoxin rho-TIA, a 19-amino acid peptide isolated from the marine snail Conus tulipa, to antagonize contractions induced by noradrenaline through activation of alpha1A-adrenoceptors in rat vas deferens, alpha1B-adrenoceptors in rat spleen and alpha1D-adrenoceptors in rat aorta, and to inhibit the ...

journal_title：European journal of pharmacology

authors： Lima V,Mueller A,Kamikihara SY,Raymundi V,Alewood D,Lewis RJ,Chen Z,Minneman KP,Pupo AS

更新日期：2005-01-31 00:00:00

abstract：:The areas S of the ventral surface of the brain stem and the immediately surrounding zone were superficially destroyed by the means of electro-coagulation, in 14 cats. This destruction produced a drop in blood pressure, which was transient in 9 and definitive in 4 animals; in one cat only the arterial pressure did not...

journal_title：European journal of pharmacology

authors： Bousquet P,Feldman J,Velly J,Bloch R

更新日期：1975-11-01 00:00:00

abstract：:As part of a program aimed at designing irreversible antagonists of the stimulant and reinforcing properties of cocaine, derivatives of GBR-12783 containing electrophilic substituents were synthesized. GBR-12783, a potent and selective inhibitor of both stimulant binding and dopamine transport, was modified to incorpo...

journal_title：European journal of pharmacology

authors： Deutsch HM,Schweri MM,Culbertson CT,Zalkow LH

更新日期：1992-09-22 00:00:00

abstract：:The effects on rat serum prolactin level of the two isomers constituting the racemic form of amisulpride were compared. (S-)-amisulpride induced hyperprolactinemia at lower doses (ED(50) = 0.09 +/- 0.01 mg/kg) than racemic- (ED(50) = 0.24 +/- 0.03 mg/kg) and (R+)-amisulpride (ED(50) = 4.13 +/- 0.05 mg/kg), in accord w...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Saba P,Gessa GL,Pani L

更新日期：2002-07-19 00:00:00

abstract：:Previous results provided evidence for an inhibitory GABAergic influence on the dopamine neurons of the rat retina, without proving that endogenous GABA physiologically regulates the activity of these cells. We injected picrotoxinin intraocularly to dark-adapted rats and measured retinal dopamine turnover. Dopamine wa...

journal_title：European journal of pharmacology

authors： Kamp CW,Morgan WW

更新日期：1981-01-29 00:00:00

abstract：:Histamine induced a dose-dependent stimulation of 3H-catecholamine(CA) efflux (superfusion procedure) from hypothalamic, striatal, hippocampal and cortical slices. The extra-hypothalamic regions were the most sensitive to histamine. Efflux of 14C-GABA and 14C-(acetyl)choline was not affected. The effect of histamine o...

journal_title：European journal of pharmacology

authors： Subramanian N,Mulder AH

更新日期：1977-05-15 00:00:00

abstract：:Hepatic and systemic insulin resistance form the core of metabolic syndrome which is also associated with cardiovascular abnormalities, inflammation, and dyslipidemia. Skeletal muscles and adipose tissues are two main target organs for glucose disposal and hence have been studied for insulin resistance too. The liver ...

journal_title：European journal of pharmacology

authors： Patel BM,Goyal RK

更新日期：2019-11-05 00:00:00

abstract：:Concentration-relaxation curves for pinacidil and cromakalim were obtained in isolated guinea-pig tracheas contracted by histamine. Pinacidil produced complete relaxation with an EC50 value of 2.8 microM. The antidiabetic sulfonylurea, glibenclamide (0.1, 1, 10 microM), caused concentration-dependent rightward shifts ...

journal_title：European journal of pharmacology

authors： Nielsen-Kudsk JE,Bang L,Brønsgaard AM

更新日期：1990-05-16 00:00:00

abstract：:A very strong epidemiological link exists between obesity, the metabolic syndrome, diabetes and diabetes-associated cardiovascular pathologies. For this reason the peripheral effects of the centrally-acting satiety adipokines, adiponectin and leptin, and of non-adipose-derived hormones with similar effects, like ghrel...

journal_title：European journal of pharmacology

authors： Elbatarny HS,Netherton SJ,Ovens JD,Ferguson AV,Maurice DH

更新日期：2007-03-08 00:00:00

abstract：:Quantitative in vitro autoradiographic techniques were used to localize and characterize 125I-labelled human calcitonin gene-related peptide ([125I]hCGRP) binding sites in sections of bovine left anterior descending coronary artery (LAD). Specific high affinity (Kd 0.4 nM) [125I]hCGRP binding sites were localized to t...

journal_title：European journal of pharmacology

authors： Knock GA,Wharton J,Gaer JA,Yacoub MH,Taylor KM,Polak JM

更新日期：1992-09-04 00:00:00

abstract：:[123I]Iodobenzofuran ([123I]IBF) is a new single photon emission computed tomography (SPECT) tracer for visualization of the dopamine D2 receptors. A tracer constant infusion paradigm was developed to measure the binding potential, density (Bmax) and affinity (KD) of the dopamine D2 receptor in baboons. Three baboons ...

journal_title：European journal of pharmacology

authors： Laruelle M,al-Tikriti MS,Zea-Ponce Y,Zoghbi SS,Baldwin RM,Charney DS,Hoffer PB,Kung HF,Innis RB

更新日期：1994-09-22 00:00:00

abstract：:Iron overload cardiomyopathy is the major cause of death in transfusion-dependent thalassemia (TDT) patients. Growing evidence demonstrates that combined iron chelators, or the combination of an iron chelator with antioxidant(s) are effective in diminishing myocardial iron deposition and attenuating cardiac dysfunctio...

journal_title：European journal of pharmacology

authors： Wongjaikam S,Kumfu S,Chattipakorn SC,Fucharoen S,Chattipakorn N

更新日期：2015-10-15 00:00:00

abstract：:The ability of the prostacyclin (IP) receptor agonist cicaprost to activate Gs-, Gq/11- and Gi-mediated cell signalling pathways has been examined in Chinese hamster ovary (CHO) cells and human embryonic kidney 293 (HEK 293) cells expressing the cloned human (hIP) or mouse (mIP) prostacyclin receptor, and compared wit...

journal_title：European journal of pharmacology

authors： Chow KB,Jones RL,Wise H

更新日期：2003-08-01 00:00:00