Different contributions of ATP and noradrenaline to neurotransmission in the isolated canine intermediate auricular artery.

abstract：:The antinociceptive profile of selected histamine H(2) and histamine H(3) receptor antagonists led to the discovery of improgan, a non-brain-penetrating analgesic agent which does not act on known histamine receptors. Because no chemical congener of improgan has yet been discovered which has both antinociceptive and b...

journal_title：European journal of pharmacology

authors： Hough LB,Nalwalk JW,Lu Q,Shan Z,Svokos K,Wentland MP,Montero MJ

更新日期：2005-10-17 00:00:00

abstract：:G protein-coupled receptors, such as the adenosine A(2A) receptor, are dynamic proteins, which undergo agonist-dependent redistribution from the cell surface to intracellular membranous compartments, such as endosomes. In order to study the kinetics of adenosine A(2A) receptor redistribution in living cells, we synthe...

journal_title：European journal of pharmacology

authors： Brand F,Klutz AM,Jacobson KA,Fredholm BB,Schulte G

更新日期：2008-08-20 00:00:00

abstract：:Hyperphosphatemia is a mineral bone-disease that increases cardiovascular complications and all-cause mortality in chronic kidney disease (CKD) patients. Oral phosphate binders absorb the dietary phosphate to prevent its high plasma levels. Moreover, they can adsorb some uremic toxins and decrease inflammation. A few ...

journal_title：European journal of pharmacology

authors： Rahbar Saadat Y,Niknafs B,Hosseiniyan Khatibi SM,Ardalan M,Majdi H,Bahmanpoor Z,Abediazar S,Zununi Vahed S

更新日期：2020-02-05 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:According to the American Society of Clinical Oncology or ASCO's clinical practice guidelines, administration of Tamoxifen for hormone receptor positive patients improved outcomes. However, many studies have been conducted in this issue, with the rise of Tamoxifen resistance in recent decades. There are many alternati...

journal_title：European journal of pharmacology

authors： Mansouri S,Naghavi-Al-Hosseini F,Farahmand L,Majidzadeh-A K

更新日期：2017-06-05 00:00:00

abstract：:The binding profile of cyclazosin, a new prazosin-related alpha 1-adrenoceptor antagonist, at alpha 1-, alpha 2-adrenoceptors, dopamine D2 and 5-HT1A receptors was compared to that of 5-methylurapidil, spiperone, risperidone and other prazosin-related ligands. In addition, cyclazosin was investigated at native and clo...

journal_title：European journal of pharmacology

authors： Giardinà D,Crucianelli M,Melchiorre C,Taddei C,Testa R

更新日期：1995-12-04 00:00:00

abstract：:Possible changes in noradrenergic function were investigated in rat frontal cerebral cortex after acute treatment (1, 2 h) with the GABAB agonist, baclofen. A single i.p. injection of d,l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (N...

journal_title：European journal of pharmacology

authors： Losada ME

更新日期：1991-05-02 00:00:00

abstract：:3-(Benzo[b]furan-5-yl)-2', 6'-dihydroxy-4'-methylpropiophenone-2'-O-(6-O-methoxycarbonyl)-bet a-D -glucopyranoside (T-1095) is a derivative of phlorizin, a potent inhibitor of Na(+)-glucose cotransporters. We determined the antidiabetic effect of T-1095 in neonatally streptozotocin-treated diabetic rats. Orally admini...

journal_title：European journal of pharmacology

authors： Oku A,Ueta K,Nawano M,Arakawa K,Kano-Ishihara T,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T

更新日期：2000-03-10 00:00:00

abstract：:The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial ...

journal_title：European journal of pharmacology

authors： Kwak YD,Marutle A,Dantuma E,Merchant S,Bushnev S,Sugaya K

更新日期：2011-01-10 00:00:00

abstract：:Janus kinase (JAK) inhibitors have recently been developed for allergic diseases. We focused on the 2 different JAK inhibitors, tofacitinib (selective for JAK3) and oclacitinib (selective for JAK1 and 2), to clarify the mechanism of anti-inflammatory and anti-itching potency of these drugs. In the process of detecting...

journal_title：European journal of pharmacology

authors： Fukuyama T,Tschernig T,Qi Y,Volmer DA,Bäumer W

更新日期：2015-10-05 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gaseous molecule and is endogenously produced in the brain by cystathionine beta-synthase, 3-mercaptopyruvate-sulfurtransferase, cysteine aminotransferase and cystathionine γ-lyase. Physiologically, H2S acts as a neuromodulator and regulates synaptic activity of neurons and glia to promote ...

journal_title：European journal of pharmacology

authors： He JT,Li H,Yang L,Mao CY

更新日期：2019-04-15 00:00:00

abstract：:Longitudinal organ bath preparations of the rat duodenum, jejunum and ileum were tested for their responsiveness to GABA-receptor agonists. The GABAA-receptor agonists, GABA and 3APS, induced non-adrenergic, non-cholinergic relaxations and/or contractions, although the magnitude and type of response varied depending u...

journal_title：European journal of pharmacology

authors： Krantis A,Harding RK

更新日期：1987-09-11 00:00:00

abstract：:Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile tu...

journal_title：European journal of pharmacology

authors： Tye NC,Horsman L,Wright FC,Large BT,Pullar IA

更新日期：1977-09-01 00:00:00

abstract：:Sprague-Dawley rats received oral doses of enalapril maleate (5 mg/kg), a potent, nonsulfhydryl, angiotensin converting enzyme inhibitor, or saline. Sixty min later, morphine sulfate, 5 mg/kg, or saline was injected subcutaneously. Response to a thermal stimulus was monitored before and up to 5 h ter morphine injectio...

journal_title：European journal of pharmacology

authors： Mojaverian P,Swanson BN,Ferguson RK

更新日期：1984-02-17 00:00:00

abstract：:The effects of loxapine and its hydroxylated metabolites 7-hydroxyloxapine and 8-hydroxyloxapine on 3H-spiroperidol binding to rat striatal membranes were investigated. Whereas 7-hydroxyloxapine and loxapine displayed strong affinities for 3H-spiroperidol binding sites, 8-hydroxyloxapine was essentially inactive. The ...

journal_title：European journal of pharmacology

authors： Coupet J,Rauh CE

更新日期：1979-04-15 00:00:00

abstract：:Major depression is a highly prevalent disorder and is predicted to be the second leading cause of disease burden by 2020. Although many antidepressant drugs are currently available, they are far from optimal. Approximately 50% of patients do not respond to initial first line antidepressant treatment, while approximat...

journal_title：European journal of pharmacology

authors： O'Leary OF,Dinan TG,Cryan JF

更新日期：2015-04-15 00:00:00

abstract：:Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in...

journal_title：European journal of pharmacology

authors： Bowers MB Jr

更新日期：1984-03-16 00:00:00

abstract：:Calcium entry blockers can effectively preserve high-energy phosphates in ischemic heart. However, little is known about the optimal timing of drug therapy. The moment of nisoldipine administration in relation to its protective efficacy during ischemia and reperfusion was studied in rat hearts. Nisoldipine (50 nM), gi...

journal_title：European journal of pharmacology

authors： De Jong JW

更新日期：1985-11-26 00:00:00

abstract：:We investigated the relationship between tension development and the cytosolic free Ca2+ level ([Ca2+]i) on exposure of the endothelium-denuded isolated rat aorta to palmitoyl-L-alpha-lysophosphatidylcholine. Lysophosphatidylcholine concentration-dependently induced a gradual increase in [Ca2+]i. Application of 10(-4)...

journal_title：European journal of pharmacology

authors： Suenaga H,Kamata K

更新日期：1999-08-06 00:00:00

abstract：:The effects of histamine H1- and H2-receptor antagonists on histamine-stimulated renin secretion were examined in anesthetized dogs. Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine. Moreover, tripelennamine alone increased renin secretion. These effects are probably ...

journal_title：European journal of pharmacology

authors： Radke KJ,Willis LR,Zimmerman GW,Weinberger MH,Selkurt EE

更新日期：1986-04-29 00:00:00

abstract：:The pathological changes of parasympathetic nerves are considered as an independent prognostic factor of the survival rate for patients with chronic liver disease. The non-selective muscarinic acetylcholine receptors (mAchR) agonists and antagonists can affect the proliferation of hepatocytes, but little is known abou...

journal_title：European journal of pharmacology

authors： Luo L,Xi C,Xu T,Zhang G,Qun E,Zhang W

更新日期：2017-07-15 00:00:00

abstract：:CGS7184 (ethyl 1-[[(4-chlorophenyl)amino]oxo]-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate) is a synthetic large-conductance Ca(2+)-activated potassium (BK(Ca)) channel opener. The existing literature suggests that potassium channels are involved in cardioprotection, particularly during ischemia-reperfusion eve...

journal_title：European journal of pharmacology

authors： Wrzosek A,Tomaskova Z,Ondrias K,Lukasiak A,Szewczyk A

更新日期：2012-09-05 00:00:00

abstract：:Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the...

journal_title：European journal of pharmacology

authors： Marumo T,Hishikawa K,Matsuzaki Y,Imai N,Takase O,Shimosawa T,Okano H,Fujita T

更新日期：2007-11-14 00:00:00

abstract：:The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Stimu...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Liska J

更新日期：1998-05-15 00:00:00

abstract：:We have investigated whether the histamine H3-receptors influence nonadrenergic noncholinergic (NANC) bronchoconstriction in guinea-pig in vivo. Atropine, propranolol, mepyramine and cimetidine were administered to block the effects of beta-adrenoceptor-, acetylcholine, H1- and H2-receptor-mediated responses, respecti...

journal_title：European journal of pharmacology

authors： Ichinose M,Barnes PJ

更新日期：1989-12-12 00:00:00

abstract：:The effect of three calcium entry blockers--verapamil, nifedipine and felodipine--on diuresis, natriuresis, the renin-aldosterone axis, and atrial natriuretic peptide (ANP) levels was studied in 30 previously untreated patients with mild to moderate essential hypertension. All three blockers produced significant antih...

journal_title：European journal of pharmacology

authors： Shamiss A,Peleg E,Rosenthal T,Ezra D

更新日期：1993-03-16 00:00:00

abstract：:Gaboxadol (THIP; 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) is an agonist at GABA(A) receptors. THIP concentrations (0.01-50 mM) were applied rapidly to Sf9 cells expressing the human alpha(1)beta(2)gamma(2S) GABA(A) receptors. The EC(50) values for the peak current in THIP alone or THIP plus 1 microM diazepam we...

journal_title：European journal of pharmacology

authors： Smith M,Lindquist CE,Birnir B

更新日期：2003-09-30 00:00:00

abstract：:Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor bl...

journal_title：European journal of pharmacology

authors： Nijkamp FP,De Jong W

更新日期：1975-06-01 00:00:00

abstract：:To characterise the safety, tolerability, pharmacodynamics (bronchodilatory effect) and pharmacokinetics of inhaled umeclidinium in patients with chronic obstructive pulmonary disease (COPD). The first investigation was a single dose, randomised, double-blind, placebo-controlled study (clinicaltrials.gov: NCT00515502)...

journal_title：European journal of pharmacology

authors： Tal-Singer R,Cahn A,Mehta R,Preece A,Crater G,Kelleher D,Pouliquen IJ

更新日期：2013-02-15 00:00:00

abstract：:Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity. In this study, we characterized the pharmacological properties of isolated bladder smooth muscle from pigs following partial outlet obstruction ...

journal_title：European journal of pharmacology

authors： Milicic I,Buckner SA,Daza A,Coghlan M,Fey TA,Brune ME,Gopalakrishnan M

更新日期：2006-02-17 00:00:00