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Effect of YM-126414 on glucose uptake and redistribution of glucose transporter isotype 4 in muscle cells.

Abstract：

:We discovered a novel compound, YM-126414 [1,3, 3-trimethyl-2-(2-phenylaminovinyl)-3H-indolium perchlorate], which stimulates glucose uptake in skeletal muscle cells in vitro. This compound increased the rate of consumption of glucose by C2C12 mouse myoblast cells in a dose-dependent manner (EC(50)=10 nM). To investigate the mechanism of this stimulation, we determined the redistribution of insulin-regulatable glucose transporter isotype 4 (Glut4). When fully differentiated C2C12 cells stably expressing myc-tagged Glut4 protein were treated with YM-126414, redistribution was dramatically increased in a dose-dependent manner (EC(50)=21 nM). These results indicate that YM-126414 is a novel glucose uptake stimulator for muscle cells by causing up-regulation of Glut4 redistribution in differentiated muscle cells. Our findings for the in vitro effects of YM-126414 suggest a direction for the development of new drugs for the treatment of type 2 diabetes.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Shimokawa T,Kagami M,Kato M,Kurosaki E,Shibasaki M,Katoh M

doi

10.1016/s0014-2999(00)00880-3

keywords:

subject

Has Abstract

pub_date

2000-12-20 00:00:00

pages

1-5

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(00)00880-3

journal_volume

410

pub_type

杂志文章

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