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Behavioral studies on the putative gamma-type endorphin receptor using different antibodies.

Abstract：

:To investigate the significance of endogenous, neuroleptic-like gamma-type endorphins and their putative receptors, polyclonal and monoclonal antibodies against gamma-type endorphins, which may bio-inactivate the ligands for the receptors, and monoclonal anti-idiotype antibodies, which presumably bind to the receptors, were injected into the nucleus accumbens of the rat brain. The desenkephalin-gamma-endorphin-induced antagonism of the hypomotility response elicited by challenge with apomorphine injected into the nucleus accumbens was used as test system. Both the anti-desenkephalin-gamma-endorphin antibodies and anti-idiotype antibodies blocked the action of exogenous desenkephalin-gamma-endorphin. Thus, the anti-idiotype antibodies may serve as receptor antagonists. Chronic treatment (injection into the nucleus accumbens) with the anti-idiotype antibodies induced sustained hypermotility, decreased habituation and impaired passive avoidance behavior. In such treated animals local treatment with apomorphine did not elicit hypomotility. It is suggested that gamma-type endorphins influence the setpoint for feedback regulation in dopaminergic neurons equipped with gamma-type endorphin receptor systems.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Van Ree JM,Wolterink G,Igarashi Y,Vanderschuren L,Wiegant VM,Rust CJ,Bruning HW

doi

10.1016/0014-2999(95)00157-g

subject

Has Abstract

pub_date

1995-06-12 00:00:00

pages

187-96

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(95)00157-G

journal_volume

279

pub_type

杂志文章

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