Abstract：
:3H-Mepyramine (3H-MEP) binds to slide-mounted tissue sections with characteristics indicating the labelling of a H1-histamine receptor. It is saturable (Bmax 12 pg/g tissue), of a high affinity (KD 0.5 mM) and possesses a drug specificity similar to that observed for H1 receptors in a variety of systems. In agreement with other biochemical studies, the association constant and the number of binding sites appear lower in the rat than in the guinea pig. Once the optimal conditions for labelling the receptors were found in the biochemical studies, tissue sections were prepared for autoradiographic studies. The receptor density varied markedly in the different brain regions. For example, there was a high density of H1 receptors in the molecular layer of the guinea pig cerebellum. In the guinea pig hippocampal formation, the highest densities were found in the molecular layer of the dentate gyrus while lower levels were found in the dendritic fields of the pyramidal cells. Significant densities of receptors were found in other areas of the rat and guinea pig brain as well.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Palacios JM,Young WS 3rd,Kuhar MJdoi
10.1016/0014-2999(79)90478-3subject
Has Abstractpub_date
1979-10-01 00:00:00pages
295-304issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(79)90478-3journal_volume
58pub_type
杂志文章abstract：:The actions of iontophoretically applied quipazine (QPZ) and 6-chloro-2-[1-piperazinyl]-pyrazine (CPP) were compared with those of serotonin (5-HT) on rat spinal motoneurones. QPZ and CPP qualitatively resembled 5-HT in that both facilitated single unit activity evoked by glutamate. Like 5-HT, the facilitation they pr...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(82)90600-8
更新日期：1982-06-16 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin. This experimental paradigm was used to prove the effectiveness of a monoclonal anti-CGRP antibody. The experiments were performed in anaesthetized rats in which intragastric capsaicin (0.5...
journal_title：European journal of pharmacology
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doi：10.1016/0014-2999(93)90645-x
更新日期：1993-11-30 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(80)90503-8
更新日期：1980-10-17 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2008.05.019
更新日期：2008-07-28 00:00:00
abstract：:There is now evidence from human studies to suggest that cardiac beta-adrenoceptor density and coupling to adenylate cyclase may be regulated in a subtype selective fashion. An animal model was used to investigate this further. Rats were infused for 6 days with the non-selective full agonist isoprenaline (n = 6) or th...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0922-4106(93)90109-m
更新日期：1993-05-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2017-07-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2004-05-03 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
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更新日期：2015-04-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-10-15 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2021-02-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2013.10.016
更新日期：2013-11-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(03)01316-5
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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更新日期：2009-08-01 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1982-08-13 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2008.06.077
更新日期：2008-09-04 00:00:00
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更新日期：2020-12-15 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1986-11-19 00:00:00
abstract：:Zolpidem has abuse potential, particularly among individuals with histories of drug abuse. This double-blind, placebo-controlled, cross over pilot study investigated the subjective effects of zolpidem (10 mg) in drug-naïve females. Over the course of a 5-h period vital signs were monitored and a series of computerized...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2008.09.011
更新日期：2008-11-19 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1984-04-20 00:00:00
abstract：:The activity of the four glycoterpenoids: two saponins, verbascosaponin A and verbascosaponin, and two iridoids, scropolioside A and scrovalentinoside, isolated from Scrophularia auriculata ssp. pseudoauriculata, were studied in different models of acute and chronic inflammation. Both saponins significantly inhibited ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(99)00846-8
更新日期：2000-02-18 00:00:00
abstract：:Gastrins and cholecystokinins contract the isolated taenia coli of the guinea-pig. Porcine CCK-39 produced the greatest contractile response and human gastrin-17 I and -34 the weakest. Pentagastrin had the highest affinity to the receptors and non-sulphated CCK-8 the lowest. The contractions produced by the CCK peptid...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(83)90244-3
更新日期：1983-06-03 00:00:00
