Serotonin: a never-ending story.

abstract：:N6-2-(4-Aminophenyl)ethyl-adenosine (APNEA, a non-selective agonist of the adenosine A3 receptors), at the subprotective dose of 1 mg/kg against electroconvulsions, significantly potentiated the anticonvulsive action of phenobarbital, diphenylhydantoin and valproate against maximal electroshock, being ineffective at l...

journal_title：European journal of pharmacology

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1997-05-30 00:00:00

abstract：:We investigated whether tolerance develops to the vasorelaxant effects of a new vasodilator, (+-)-(E)-4-ethyl-2-[(E)-hydroxy-imino]-5-nitro-3-hexenamide (FK409), in isolated canine coronary artery strips and to its hypotensive effect in rats, and whether FK409 activates soluble guanylate cyclase isolated from vascular...

journal_title：European journal of pharmacology

authors： Isono T,Sato N,Yamamoto T,Sawada T,Yamazaki S,Miura S,Furuichi A,Ozaki R,Koibuchi Y,Ohtsuka M

更新日期：1994-08-01 00:00:00

abstract：:The use-dependent effects of bunazosin on the maximal rate of rise (Vmax) of the action potential and conduction velocity were studied in isolated papillary muscles of guinea-pig. Standard microelectrode techniques were used to monitor the conduction and action potential of the muscles. In the presence of 30 microM bu...

journal_title：European journal of pharmacology

authors： Hasegawa J,Noguchi N,Sawaguchi M,Doi T,Hisatome I,Kotake H,Mashiba H

更新日期：1990-12-04 00:00:00

abstract：:The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatmen...

journal_title：European journal of pharmacology

authors： Zerrouk A,Auguet M,Dabiré H,Brisac AM,Safar M,Chabrier PE

更新日期：1999-06-11 00:00:00

abstract：:This study compared the peripheral analgesic effects of a novel opioid agonist 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU), to that of non-peptide (morphine, fentanyl) and peptide opioid agonists (Met-enkephalin; met-ENK and β-endorphin; β-END) in a model of localized inflammatory pain evoked by intraplantar (i.pl.)...

journal_title：European journal of pharmacology

authors： Khalefa BI,Mousa SA,Shaqura M,Lackó E,Hosztafi S,Riba P,Schäfer M,Ferdinandy P,Fürst S,Al-Khrasani M

更新日期：2013-08-05 00:00:00

abstract：:The study compared the efficacy of acute versus chronic metrifonate treatment to improve initial and reversal learning of the water maze spatial navigation task in medial septal-lesioned rats. Acute oral administration of 30 mg/kg metrifonate at 30 min, but not at 150 or 360 min, before training improved the initial a...

journal_title：European journal of pharmacology

authors： Riekkinen M,Schmidt BH,Riekkinen P Jr

更新日期：1997-11-05 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the biosynthesis of prostaglandins from arachidonic acid and plays a critical role in some pathologies including inflammation, neurodegenerative diseases and cancer. Cryptotanshinone is a major constituent of tanshinones, which are extracted from the medicinal he...

journal_title：European journal of pharmacology

authors： Jin DZ,Yin LL,Ji XQ,Zhu XZ

更新日期：2006-11-07 00:00:00

abstract：:When the prostate cancer cells become unresponsive to androgen therapy, resistance to chemotherapy becomes imminent, resulting in high mortality. To combat this situation, lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatum spores, was tested against hormone sensitive (LnCaP)...

journal_title：European journal of pharmacology

authors： Bishayee K,Chakraborty D,Ghosh S,Boujedaini N,Khuda-Bukhsh AR

更新日期：2013-01-05 00:00:00

abstract：:We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 2...

journal_title：European journal of pharmacology

authors： Takahata O,Krolikowski JG,McCallum JB,Lathrop DA,Bosnjak ZJ

更新日期：1998-08-21 00:00:00

abstract：:We investigated the effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes. Of the branched-chain amino acids, only leucine (10(-5)-10(-3) M) induced hepatocyte DNA synthesis and proliferation in a time- and dose-dependent manner. The addition of valine or...

journal_title：European journal of pharmacology

authors： Kimura M,Ogihara M

更新日期：2005-03-14 00:00:00

abstract：:The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephr...

journal_title：European journal of pharmacology

authors： Fortes ZB,Scivoletto R,Garcia-Leme J

更新日期：1989-10-24 00:00:00

abstract：:Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...

journal_title：European journal of pharmacology

authors： D'Amico M,Rossi F,Warner TD

更新日期：1997-06-05 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:Calsequestrin (CASQ) is a major Ca(2+) storage protein within the sarcoplasmic reticulum (SR) of both cardiac and skeletal muscles. CASQ reportedly acts as a Ca(2+) buffer and Ca(2+)-channel regulator through its unique Ca(2+)-dependent oligomerization, maintaining the free Ca(2+) concentration at a low level (0.5-1mM...

journal_title：European journal of pharmacology

authors： Kang C,Nissen MS,Sanchez EJ,Lam KS,Milting H

更新日期：2010-11-10 00:00:00

abstract：:Aim of the present study was to evaluate the effects of physical stressors (electric foot-shocks) on effect of the antidepressant drug, clomipramine and plasma corticosterone levels in male and female rats tested in a model of behavioral despair (forced swim test,). Male and female rats of the Wistar strain were injec...

journal_title：European journal of pharmacology

authors： Consoli D,Fedotova J,Micale V,Sapronov NS,Drago F

更新日期：2005-09-27 00:00:00

abstract：:The polyphenolic flavonoid silymarin that is the milk thistle extract has been found to possess an anti-cancer effect against various human epithelial cancers. In this study, to explore the regulative effect of silymarin on human ovarian cancer line A2780s and PA-1 cells, 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltet...

journal_title：European journal of pharmacology

authors： Fan L,Ma Y,Liu Y,Zheng D,Huang G

更新日期：2014-11-15 00:00:00

abstract：:Complete control of emesis caused by cyclophosphamide (CPA) is of immense interest to both patients and physicians. Serotonin 5-HT3- and tachykinin NK1-receptor antagonists are widely used antiemetics in clinic, but they fail to completely control CPA-induced emesis. New antiemetic targets for the full control of CPA-...

journal_title：European journal of pharmacology

authors： Alkam T,Chebolu S,Darmani NA

更新日期：2014-01-05 00:00:00

abstract：:Infusion of renal side population (SP) cells, enriched with adult stem-like cells, can ameliorate acute renal failure. We investigated the effects of an angiotensin II type 1 (AT(1)) receptor antagonist, valsartan on SP cell changes in renal injury by ureteral obstruction. Renal SP fraction was reduced by 38%, and the...

journal_title：European journal of pharmacology

authors： Marumo T,Hishikawa K,Matsuzaki Y,Imai N,Takase O,Shimosawa T,Okano H,Fujita T

更新日期：2007-11-14 00:00:00

abstract：:Substance P causes histamine release from rat peritoneal mast cells probably through direct activation of a specific G protein at micromolar concentrations. We found that peritoneal mast cells of a substrain of Wistar rats (Std:Wistar) responds to nanomolar concentrations of substance P by releasing histamine in a con...

journal_title：European journal of pharmacology

authors： Ogawa K,Nabe T,Yamamura H,Kohno S

更新日期：1999-06-18 00:00:00

abstract：:The inhibitory effect of forskolin-stimulated 3',5'-cyclic monophosphate (c-AMP) synthesis in isolated rat adipocytes has been measured for eight typical adenosine receptor agonists. The percent inhibition was evaluated using concentrations of each compound corresponding to 100 times their Ki, inhibitory binding const...

journal_title：European journal of pharmacology

authors： Borea PA,Varani K,Dalpiaz A,Capuzzo A,Fabbri E,IJzerman AP

更新日期：1994-03-15 00:00:00

abstract：:Bacterial colonization might influence the clinical response of psoriasis patients to the therapeutic efficacy of immunosuppressive drugs. Macroride antibiotics are used for the treatment of psoriasis patients; however, few studies have investigated the immunoregulatory efficacy of macrorides in bacterial superantigen...

journal_title：European journal of pharmacology

authors： Kamogawa S,Kagami K,Maeda M,Arai K,Okubo Y,Tsuboi R,Hirano T

更新日期：2009-01-14 00:00:00

abstract：:Microinjections of substance P (SP, 100 pmol) into the dorsal raphe nucleus (DRN) in conscious rats increased blood pressure and heart rate for 30-40 min. Concomitantly, the extracellular levels of 5-hydroxytryptamine (5-HT) in the ventral hippocampus, monitored by microdialysis, increased by 30% for 20 min compared w...

journal_title：European journal of pharmacology

authors： Gradin K,Qadri F,Nomikos GG,Hillegaart V,Svensson TH

更新日期：1992-08-06 00:00:00

abstract：:Type 1 diabetes (T1D) is a multifactorial autoimmune disease that develops as a consequence of macrophage- and T cell-dependent pancreatic β-cell death. Multiple approaches for induction of anti-inflammatory/regulatory mechanisms that would attenuate T1D have been utilized, with little or no beneficial effects. To ach...

journal_title：European journal of pharmacology

authors： Koprivica I,Gajic D,Saksida T,Cavalli E,Auci D,Despotovic S,Pejnovic N,Stosic-Grujicic S,Nicoletti F,Stojanovic I

更新日期：2019-12-01 00:00:00

abstract：:Using a number of agonist and antagonist compounds, we attempted to characterize the responses and receptors involved in the effects of 5-hydroxytryptamine (5-HT) in the in situ blood perfused rat mesentery. An intra-arterial (i.a.) bolus injection of 5-HT increased mesenteric perfusion pressure in a dose-dependent wa...

journal_title：European journal of pharmacology

authors： Fernández MM,Morán A,Martín ML,San Román L

更新日期：2000-08-04 00:00:00

abstract：:Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a way of preventing cancer who takes advantage of plant phytochemicals and synthetic c...

journal_title：European journal of pharmacology

authors： Zhu Y,Yang Q,Liu H,Song Z,Chen W

更新日期：2020-11-15 00:00:00

abstract：:The purpose of the current study was to assess neuropeptidergic alterations during a phase of the drug addiction cycle associated with drug craving as compared to a time period when the drug had been recently self-administered. Male Wistar rats were allowed to self-administer cocaine, heroin or saline for 6 h for 5 co...

journal_title：European journal of pharmacology

authors： Cappendijk SL,Hurd YL,Nylander I,van Ree JM,Terenius L

更新日期：1999-01-22 00:00:00

abstract：:Impaired ventricular repolarization can lead to long QT syndrome (LQT), a proarrhythmic disease with high risk of developing lethal ventricular tachyarrhythmias. The compound ICA-105574 is a recently developed hERG activator and it enhances IKr current with very high potency by removing the channel inactivation. The p...

journal_title：European journal of pharmacology

authors： Meng J,Shi C,Li L,Du Y,Xu Y

更新日期：2013-10-15 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:The effects of three vinca derivatives on [3H]batrachotoxin binding in rat cortical synaptosomes, on the inhibition of whole-cell Na+ currents evoked in voltage-clamped cortical neurones of the rat, on the protection against veratridine-induced cell death in cortical cultures and on the maximal electroshock-induced se...

journal_title：European journal of pharmacology

authors： Erdo SA,Molnár P,Lakics V,Bence JZ,Tömösközi Z

更新日期：1996-10-24 00:00:00

abstract：:Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains various compounds with biological effects, such as anti-viral, anti-inflammatory, immunoregulatory, anti-tumor and neuroprotective effect...

journal_title：European journal of pharmacology

authors： Nakatani Y,Kobe A,Kuriya M,Hiroki Y,Yahagi T,Sakakibara I,Matsuzaki K,Amano T

更新日期：2017-11-15 00:00:00