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Endogenous noradrenergic tone controls symptoms of allodynia in the spinal nerve ligation model of neuropathic pain.

Abstract：

:Endogenous inhibitory controls were studied in the spinal nerve ligation model of neuropathic pain. Atipamezole, a selective alpha2-adrenoceptor antagonist, produced both mechanical and cold allodynia in those rats which had not developed clear neuropathic symptoms. The same doses (50 microg i.t. or 1 mg/kg s.c.) did not increase the severity of symptoms in rats which had developed them. The opioid receptor antagonist naloxone (20 microg i.t. or 1 mg/kg s.c.) had no effect on the neuropathic symptoms. These results indicate that mechanical and cold allodynia are under endogenous noradrenergic rather than opioidergic control in this model of neuropathic pain.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Xu M,Kontinen VK,Kalso E

doi

10.1016/s0014-2999(98)00910-8

keywords:

subject

Has Abstract

pub_date

1999-01-29 00:00:00

pages

41-5

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(98)00910-8

journal_volume

366

pub_type

杂志文章

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