Failure of opiates to reverse dopamine inhibition of prolactin secretion in vitro.

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine i...

journal_title：European journal of pharmacology

authors： Moosavi M,SoukhakLari R,Moezi L,Pirsalami F

更新日期：2018-01-15 00:00:00

abstract：:The effect of some tryptaminergic drugs on electroshock fighting behaviour in rats was determined. Reserpine and tetrabenazine reduced the fighting responses while 5-hydroxytryptophan increased the fighting responses in normal as well as reserpine-treated animals. p-Chlorophenylalanine, a specific depletor of brain se...

journal_title：European journal of pharmacology

authors： Anand M,Gupta GP,Bhargava KP

更新日期：1976-10-01 00:00:00

abstract：:High stereoselectivity was observed for the enantiomers of trihexyphenidyl and trihexyphenidyl methiodide at muscarinic M1-receptors in field-stimulated rabbit vas deferens and at M2 alpha- and M2 beta-receptors in guinea-pig atrium and ileum, respectively. Considerably higher affinities (up to 1700-fold) were found f...

journal_title：European journal of pharmacology

authors： Lambrecht G,Feifel R,Moser U,Aasen AJ,Waelbroeck M,Christophe J,Mutschler E

更新日期：1988-10-11 00:00:00

abstract：:Ketamine, a non-selective inhibitor of NMDA (N-methyl-D-aspartate) channels is used in anesthetic or sub-anesthetic doses to induce analgesia, amnesia, to suppress fear, anxiety and depression. Although the ketamine's effect on memory acquisition is known, its effects on other aspects of memory are controversial. Morr...

journal_title：European journal of pharmacology

authors： Moosavi M,Yadollahi Khales G,Rastegar K,Zarifkar A

更新日期：2012-02-29 00:00:00

abstract：:Although the vasorelaxant effects of taurine have been studied in rabbit ear artery, rat isolated aorta and mesenteric artery, its pharmacological properties in other vascular beds and underlying mechanism(s) are still not well clarified. The present study was designed to observe the effects of taurine on the contract...

journal_title：European journal of pharmacology

authors： Niu LG,Zhang MS,Liu Y,Xue WX,Liu DB,Zhang J,Liang YQ

更新日期：2008-02-02 00:00:00

abstract：:The long-term survival of rats with healed myocardial infarction and congestive heart failure treated with milrinone, enalapril and the combination of milrinone plus enalapril, was documented. Seven days after sham or coronary ligation, 200 rats (99 sham and 101 myocardial infarcted) were randomized based on electroca...

journal_title：European journal of pharmacology

authors： Sweet CS,Ludden CT,Stabilito II,Emmert SE,Heyse JF

更新日期：1988-02-16 00:00:00

abstract：:Changrolin (2, 6-bis[pyrrolidin-1-ylmethyl]-4-[quinazolin-4-ylamino] phenol) is an anti-arrhythmic drug derived from β-dichroine, an active component of the Chinese medicinal herb, Dichroa febrifuga Lour. To elucidate the mechanism underlying the anti-arrhythmic effect of changrolin, we used the whole-cell patch-clamp...

journal_title：European journal of pharmacology

authors： Chen WH,Yang D,Wang WY,Zhang J,Wang YP

更新日期：2010-11-25 00:00:00

abstract：:The concentrations of p-tyramine (p-TA), m-tyramine (m-TA), dopamine (DA) and their principal metabolites, p-hydroxyphenylacetic acid (p-HPAA), m-hydroxyphenylacetic acid (m-HPAA) and homovanillic acid (HVA) were determined in the corpus striatum of Swiss mice at various times after the subcutaneous administration of ...

journal_title：European journal of pharmacology

authors： McQuade PS,Juorio AV

更新日期：1982-09-24 00:00:00

abstract：:Angiotensin AT1 receptor antagonists are divided into two types, surmountable and insurmountable, based on the way they inhibit angiotensin II-induced vasoconstriction. To elucidate what causes the difference, we studied how antagonists associate with and dissociate from AT1 receptor sites in rat liver membranes. Thre...

journal_title：European journal of pharmacology

authors： Hara M,Kiyama R,Nakajima S,Kawabata T,Kawakami M,Ohtani K,Itazaki K,Fujishita T,Fujimoto M

更新日期：1995-04-28 00:00:00

abstract：:Thaliporphine (0.1-100 microM) produced sustained, concentration-dependent contraction in isolated rings of rat aorta. Thaliporphine (ED50 = 1.5 +/- 0.5 microM) was less potent than endothelin (ED50 = 3.9 +/- 0.4 nM), but was more potent than Bay K 8644 (ED50 = 5.5 +/- 0.6 microM). Thaliporphine also contracted guinea...

journal_title：European journal of pharmacology

authors： Teng CM,Yu SM,Lee SS,Ko FN,Su MJ,Huang TF

更新日期：1993-03-16 00:00:00

abstract：:The aim of this study was to investigate the relaxation effect of farrerol on rat aortic vascular smooth muscle cells (VSMCs) and its underlying mechanism. VSMCs were cultured primarily and were used to examine the relaxation effect of farrerol. Cells surface and length were measured by dynamic observation, or by rhod...

journal_title：European journal of pharmacology

authors： Qin X,Hou X,Zhang K,Li Q

更新日期：2019-06-15 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...

journal_title：European journal of pharmacology

authors： Kennedy RH,Seifen E,Kafiluddi R

更新日期：1986-09-23 00:00:00

abstract：:Canine femoral arteries responded to acetylcholine with relaxations; these were abolished in potassium free solution, restored by potassium or rubidium but not by cesium or amonium. Potassium and rubidium were equipotent in inducing ouabain-sensitive relaxation, while amonium and cesium were less potent. The results (...

journal_title：European journal of pharmacology

authors： De Mey J,Vanhoutte PM

更新日期：1980-10-03 00:00:00

abstract：:The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations depended on dose and were reached < or = 1 h after an oral dose of oxcarbazepine and < 2 h after monohydroxy derivative. In mice,...

journal_title：European journal of pharmacology

authors： Wamil AW,Schmutz M,Portet C,Feldmann KF,McLean MJ

更新日期：1994-12-27 00:00:00

abstract：:Bradykinin (BK; 10(-10)-10(-7) M) relaxes phenylephrine-contracted rabbit isolated pulmonary arterial rings. The mechanical destruction of the endothelial layer obliterates acetylcholine (ACh) and A23187-induced relaxation without influencing BK-, isoproterenol-, sodium nitroprusside- and papaverine-induced relaxation...

journal_title：European journal of pharmacology

authors： Chand N,Mahoney TP Jr,Diamantis W,Sofia RD

更新日期：1987-06-04 00:00:00

abstract：:Co-dergocrine (Hydergine), an ergot preparation composed of four dihydrogenated peptide ergot alkaloids (dihydroergocornine, dihydroergocristine, dihydro-alpha-ergokryptine, dihydro-beta-ergokryptine, 3:3:2:1), has been reported to exert in vivo effects suggesting an interaction with dopaminergic systems. The present ...

journal_title：European journal of pharmacology

authors： Markstein R

更新日期：1982-12-24 00:00:00

abstract：:Perfused rabbit hearts removed 3H-5-hydroxytryptamine (3H-5-HT) from a perfusion solution containing 2.6 ng/ml and a tissue-to-medium ratio of about 10 was achieved after a 55 min perfusion period. 12.4 +/- 1.0% of the cardiac total radioactivity consisted of metabolites and metabolites appeared in the venous effluent...

journal_title：European journal of pharmacology

authors： Fozard JR,Berry JL

更新日期：1975-06-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) plays a major role at the level of the hypothalamus and pituitary to control the body's response mechanisms to stressful stimuli. The recent discovery of CRF outside the central nervous system suggests that CRF may well play a similar role in peripheral tissues, most likely in a pa...

journal_title：European journal of pharmacology

authors： Schäfer M,Mousa SA,Stein C

更新日期：1997-03-26 00:00:00

abstract：:Dipeptidyl peptidase IV (DPP IV) is the primary inactivator of glucoregulatory incretin hormones. This has lead to development of DPP IV inhibitors as a new class of agents for the treatment of type 2 diabetes. Recent reports indicate that other antidiabetic drugs, such as metformin, may also have inhibitory effects o...

journal_title：European journal of pharmacology

authors： Duffy NA,Green BD,Irwin N,Gault VA,McKillop AM,O'Harte FP,Flatt PR

更新日期：2007-07-30 00:00:00

abstract：:Cabergoline 1-[(6-allylergolin-8 beta-yl)carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea is a recently developed ergot derivative with a long-lasting dopamine agonist action. We now studied the ability of cabergoline to counteract the development of a prolactin-secreting tumor (prolactinoma) induced in female rats ...

journal_title：European journal of pharmacology

authors： Dall'Ara A,Lima L,Cocchi D,Di Salle E,Cancio E,Devesa J,Müller EE

更新日期：1988-06-22 00:00:00

abstract：:Here, we present a neuroendocrine concept to review the circularly interacting energy homeostasis system between brain and body. Body-brain interaction is circular because the brain immediately integrates an input to an output, and because part of this response may be that the brain modulates the sensitivity of this p...

journal_title：European journal of pharmacology

authors： Kreier F,Kalsbeek A,Ruiter M,Yilmaz A,Romijn JA,Sauerwein HP,Fliers E,Buijs RM

更新日期：2003-11-07 00:00:00

abstract：:This study evaluated the contribution of supraspinal opioid receptors to the production of antinociception, in the rat. I.c.v. administration of a selective mu- (DAMGO) and a selective delta- (DPDPE), but not a selective kappa- (U50,488H) opioid receptor agonist, produced significant dose-dependent increase in mechani...

journal_title：European journal of pharmacology

authors： Miaskowski C,Taiwo YO,Levine JD

更新日期：1991-12-03 00:00:00

abstract：:Phenylethylamine (PEA) has been implicated in a number of central and peripheral nervous system disorders. Its possible mechanisms of action include stimulation via catecholamine release and direct stimulation by PEA. We have examined the effects of PEA on isolated vascular smooth muscle (VSM) to further explore the m...

journal_title：European journal of pharmacology

authors： Hansen TR,Greenberg J,Mosnaim AD

更新日期：1980-05-02 00:00:00

abstract：:The effects of intra-amygdalar neuropeptide Y infusions were assessed in rats using the social interaction test. Neuropeptide Y administered into the central nucleus of the amygdala did not alter behavior, while injections into the basolateral nucleus of the amygdala produced an increased social interaction time. Furt...

journal_title：European journal of pharmacology

authors： Sajdyk TJ,Vandergriff MG,Gehlert DR

更新日期：1999-03-05 00:00:00

abstract：:The models currently used to assess antinociceptive efficacy in animals are far from ideal. Those procedures that detect both opioid agonists and mixed agonist-antagonists fail to differentiate between them unless the noxious stimulus is adjusted. Furthermore, changes in the sensitivity of the test often result in pos...

journal_title：European journal of pharmacology

authors： Pizziketti RJ,Pressman NS,Geller EB,Cowan A,Adler MW

更新日期：1985-12-10 00:00:00

abstract：:Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole ca...

journal_title：European journal of pharmacology

authors： Aceto MD,Scates SM,Lowe JA,Martin BR

更新日期：1995-08-25 00:00:00

abstract：:Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated. Hydrogen sulphide is an endogenously produced signal transduction molecule with strong...

journal_title：European journal of pharmacology

authors： Dam VP,Scott JL,Ross A,Kinobe RT

更新日期：2012-06-15 00:00:00

abstract：:We have reported that tacrolimus (FK506), an immunosuppressive drug, and diclofenac, a non-steroidal anti-inflammatory drug, possess different modes of neuroprotective action. FK506 suppresses only thapsigargin-induced apoptosis in neuroblastoma SH-SY5Y cells while diclofenac reverses tunicamycin-induced as well as th...

journal_title：European journal of pharmacology

authors： Yamazaki T,Muramoto M,Okitsu O,Morikawa N,Kita Y

更新日期：2011-11-01 00:00:00

abstract：:The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those reported for native NMDA receptors. The order of affinity for [3H]glutamate was NR1-NR2B > NR1-NR2A approximately NR1-NR2D ...

journal_title：European journal of pharmacology

authors： Laurie DJ,Seeburg PH

更新日期：1994-08-16 00:00:00