Effect of tryptaminergic drugs on electroshock fighting behaviour in rats.

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:Restraint for 1 h induced significant antinociceptive activity, as assessed by the hot plate test, in female mice. The antinociceptive activity was significant throughout the 1 h period of observation starting immediately after restraint. Prior administration of the histamine H2 receptor agonist dimaprit (1.5-6.0 mg/k...

journal_title：European journal of pharmacology

authors： Wong CL

更新日期：1995-06-12 00:00:00

abstract：:Endothelin-1-(1-31) is a new bioactive 31-amino-acid-length peptide generated from big endothelin-1 by chymase or other chymotrypsin-type proteases with various pathophysiologic functions. In this study, we have detected the specific and monophasic binding of [125I]endothelin-1-(1-31) in porcine lung membranes. Compet...

journal_title：European journal of pharmacology

authors： Kitamura H,Cui P,Sharmin S,Yano M,Kido H

更新日期：2003-03-28 00:00:00

abstract：:Peripheral nerve injury, which gives rise to persistent chronic pain, has become an area of intense research activity, largely because it represents a disorder with a high unmet medical need. In this study, serum biomarkers of the spinal nerve ligation model were successfully investigated with the metabolomic method. ...

journal_title：European journal of pharmacology

authors： Mao YF,Liu XR,Liao XZ,Lv YH,Xu H,Deng XM,Yan SK,Xiong YC,Zhang WD

更新日期：2009-08-01 00:00:00

abstract：:Diabetic hyperglycemia causes a variety of pathological changes. Astragaloside IV (AS-IV) was widely used for the treatment of cardiovascular diseases in China. The aim of this study was to determine the effect of AS-IV on bone marrow mesenchymal stem cells (MSCs) and the underlying mechanism in diabetes. We used reve...

journal_title：European journal of pharmacology

authors： Li M,Yu L,She T,Gan Y,Liu F,Hu Z,Chen Y,Li S,Xia H

更新日期：2012-12-05 00:00:00

abstract：:Influenza is a major disease in humans. The reemergence of avian influenza A viruses has indicated that hyperinflammatory responses are closely related to the severity of disease. Influenza virus infection induces nuclear transcription factor kappaB (NF-kappaB) activation. NF-kappaB and NF-kappaB-dependent gene produc...

journal_title：European journal of pharmacology

authors： Onose A,Hashimoto S,Hayashi S,Maruoka S,Kumasawa F,Mizumura K,Jibiki I,Matsumoto K,Gon Y,Kobayashi T,Takahashi N,Shibata Y,Abiko Y,Shibata T,Shimizu K,Horie T

更新日期：2006-07-17 00:00:00

abstract：:The effect of potassium on the binding of digoxin or digoxigenin to isolated Na+, K+-ATPase was compared with that of potassium on the positive inotropic action of the agents in guinea-pig hearts. The binding of digoxigenin to the enzyme in vitro was reduced to a greater extent by potassium than was the binding of dig...

journal_title：European journal of pharmacology

authors： Akera T,Wiest SA,Brody TM

更新日期：1979-08-15 00:00:00

abstract：:(-)Piquindone is a new antipsychotic pyrroloisoquinoline derivative that binds to dopamine D2 receptors. We used in vitro quantitative autoradiography to determine the distribution of [3H](-)piquindone binding sites in rat forebrain. [3H](-)Piquindone binding to brain slices was sodium dependent, saturable and of high...

journal_title：European journal of pharmacology

authors： Nock B,Sedvall G,Mcewen BS

更新日期：1986-03-04 00:00:00

abstract：:In this study the desensitizing power of increasing concentrations of resiniferatoxin applied topically to the bladder mucosa, and the irritating properties of the most effective desensitizing dose, were determined with the aid of the spinal expression of the proto-oncogene c-fos. Desensitization was assessed by the d...

journal_title：European journal of pharmacology

authors： Avelino A,Cruz F,Coimbra A

更新日期：1999-07-28 00:00:00

abstract：:Bisphosphonates, which are extensively used in bone-related disorders, have been reported to inhibit atherosclerosis and neointimal hyperplasia. In the present study, we investigated the effects of a bisphosphonate, zoledronate, on the proliferation, adhesion, migration and microstructure of vascular smooth muscle cel...

journal_title：European journal of pharmacology

authors： Wu L,Zhu L,Shi WH,Zhang J,Ma D,Yu B

更新日期：2009-01-05 00:00:00

abstract：:Some behavioural effects of flunitrazepam were investigated in two sets of experiments in C57BL/6 mice. In the first set, flunitrazepam administration (0.025 or 0.05 mg/kg) enhanced the locomotor activity of mice. In the second set, memory impairments were observed following posttraining (immediately or 30 min, but no...

journal_title：European journal of pharmacology

authors： Castellano C,Filibeck U,Pavone F

更新日期：1984-09-03 00:00:00

abstract：:Clearance of apoptotic cells, so-called efferocytosis, by alveolar macrophages (AMs) is important for lung homeostasis and is impaired in pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease and asthma. Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and ...

journal_title：European journal of pharmacology

authors： Inoue M,Ishibashi Y,Nogawa H,Yasue T

更新日期：2012-02-29 00:00:00

abstract：:Crocetin, an aglycone of crocin, is found both in the saffron crocus (Crocus starus L.) and in gardenia fruit (Gardenia jasminoides Ellis). We evaluated the protective effects of crocetin against the retinal ischemia induced by 5h unilateral ligation of both the pterygopalatine artery (PPA) and the external carotid ar...

journal_title：European journal of pharmacology

authors： Ishizuka F,Shimazawa M,Umigai N,Ogishima H,Nakamura S,Tsuruma K,Hara H

更新日期：2013-03-05 00:00:00

abstract：:The repeated administration of N-methyl-beta-carboline-3-carboxamide (FG 7142) to mice leads to 'chemical kindling', i.e. the development of seizures in response to doses which were initially insufficient to produce convulsive activity. To determine if chemical kindling produced changes in the GABAA receptor/chloride ...

journal_title：European journal of pharmacology

authors： Lewin E,Peris J,Bleck V,Zahniser NR,Harris RA

更新日期：1989-01-24 00:00:00

abstract：:GABAA receptors are pentameric chloride ion channels that are opened by GABA. We have screened a cell line derived from human glioblastoma, U3047MG, for expression of GABAA receptor subunit isoforms and formation of functional ion channels. We identified GABAA receptors subunit α2, α3, α5, β1, β2, β3, δ, γ3, π, and θ ...

journal_title：European journal of pharmacology

authors： Babateen O,Jin Z,Bhandage A,Korol SV,Westermark B,Forsberg Nilsson K,Uhrbom L,Smits A,Birnir B

更新日期：2015-02-05 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

journal_title：European journal of pharmacology

authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

更新日期：2001-01-05 00:00:00

abstract：:In addition to S(-)-nicotine, several minor tobacco alkaloids ((+/-)-nornicotine, anabaseine, S(-)-anabasine, and S(-)-N-methylanabasine) are present in tobacco smoke. This study demonstrates that these alkaloids increase fractional 3H release in a concentration-dependent manner from rat striatal slices preloaded with...

journal_title：European journal of pharmacology

authors： Dwoskin LP,Teng L,Buxton ST,Ravard A,Deo N,Crooks PA

更新日期：1995-03-24 00:00:00

abstract：:The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO ...

journal_title：European journal of pharmacology

authors： Haigh JR,Feely M

更新日期：1988-03-01 00:00:00

abstract：:The comparative dromotropic activity of timolol (TML) and propranolol (PPL) was studied by means of His bundle electrograms in two groups of pentobarbital-anesthetized dogs: group I, 7 non-atropinized dogs; group II, 8 atropinized dogs. beta-Blocking agents were injected in 4 cumulative doses in each dog at 3 days' in...

journal_title：European journal of pharmacology

authors： Jaillon P,Heckle J,Weissenburger J,Cheymol G

更新日期：1978-01-15 00:00:00

abstract：:Three membrane preparations of rat cortex were used to examine the effects of GABA, bicuculline and bicucine on specific 3H-diazepam binding. In the crude synaptosomal fraction, GABA had no effect on either the maximal binding capacity (Bmax) or dissociation constant (KD) of 3H-diazepam binding. Bicuculline and bicuci...

journal_title：European journal of pharmacology

authors： Chiu TH,Rosenberg HC

更新日期：1979-07-01 00:00:00

abstract：:Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected ...

journal_title：European journal of pharmacology

authors： Lee YW,Kim DH,Jeon SJ,Park SJ,Kim JM,Jung JM,Lee HE,Bae SG,Oh HK,Son KH,Ryu JH

更新日期：2013-03-15 00:00:00

abstract：:The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are metabolised by cells by hydrolysis to arachidonic acid followed by esterification into phospholipids. Here, we report that nitric oxide (NO) donors significantly increase the amount of tritium accumulated in the cell membranes of RBL2H3 rat ba...

journal_title：European journal of pharmacology

authors： Thors L,Fowler CJ

更新日期：2009-10-25 00:00:00

abstract：:(-)-3/-Norepinephrine (3H-NE) binding to the microsomal fraction of the rabbit aorta has been studied. Binding appears to increase linearly with time up to at least 30 min, shows no evidence of stereoselectivity and may be inhibited only by compounds possessing the catechol or 3-methoxy-4hydroxyphenyl moieties, with t...

journal_title：European journal of pharmacology

authors： Ruffolo RR,Mccreery RL,Patil PN

更新日期：1976-08-01 00:00:00

abstract：:We investigated the involvement of dopamine D1 and D2 receptor subtypes in the effects of GBR 12909, a selective dopamine uptake inhibitor, on latent learning in the performance of a water-finding task and on locomotor activity in mice. GBR 12909 (10 and 20 mg/kg) impaired latent learning, and this effect was countera...

journal_title：European journal of pharmacology

authors： Ichihara K,Nabeshima T,Kameyama T

更新日期：1993-04-06 00:00:00

abstract：:We investigated the effects of beta-estradiol, dehydroepiandrosterone and dehydroepiandrosterone sulfate on intracellular calcium concentration ([Ca(2+)](i)) increases induced by gamma-aminobutyric acid (GABA), high K(+) and N-methyl-D-aspartate acid (NMDA) in cultured hippocampal neurons. Acute treatment with beta-es...

journal_title：European journal of pharmacology

authors： Kurata K,Takebayashi M,Kagaya A,Morinobu S,Yamawaki S

更新日期：2001-03-30 00:00:00

abstract：:A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging f...

journal_title：European journal of pharmacology

authors： Seutin V,Verbanck P,Massotte L,Dresse A

更新日期：1989-05-19 00:00:00

abstract：:This work investigates the actions of LASSBio-1289, (E)-N-methyl-N'-(thiophen-3-methylene)benzo[d][1,3]dioxole-5-carbohydrazide, on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats. Two weeks following the MCT injection, LASSBio-1289 (50 or 75mg/kg, p.o.) or vehicle was administrated once dail...

journal_title：European journal of pharmacology

authors： Pereira SL,Kummerle AE,Fraga CA,Barreiro EJ,Rocha Nde N,Ferraz EB,do Nascimento JH,Sudo RT,Zapata-Sudo G

更新日期：2013-02-28 00:00:00

abstract：:Three agents with K+ channel blocking activity, procaine, 4-aminopyridine (4-AP) and tetraethylammonium (TEA), were tested for inhibition of vasorelaxation and 86Rb+ efflux induced by cromakalim (BRL 34915), pinacidil and nicorandil in rabbit isolated mesenteric artery. The potency order for inhibition of vasorelaxati...

journal_title：European journal of pharmacology

authors： Wilson C,Coldwell MC,Howlett DR,Cooper SM,Hamilton TC

更新日期：1988-08-02 00:00:00

abstract：:The earliest hallmarks of sporadic Alzheimer's disease (sAD) are impaired glucose metabolism, chronic neuroinflammation, diminished synaptic plasticity and subsequent cognitive decline. The safest antidiabetic drug metformin has shown both glucose metabolism-improving and cognition-enhancing action in type 2 diabetes ...

journal_title：European journal of pharmacology

authors： Pilipenko V,Narbute K,Pupure J,Langrate IK,Muceniece R,Kluša V

更新日期：2020-08-15 00:00:00