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Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor.

Abstract：

:The calmodulin inhibitor 1,3-dihydro-1-[1-((4-methyl-4H,6H-pyrrolo[1,2-a]-[4,1]benzoxazepin - 4-yl)methyl)-4-piperidinyl]-2H-benzimidazol-2-one maleate (CGS 9343B) caused a reversible block of voltage-activated Ca2+, Na+, and K+ currents in differentiated rat pheochromocytoma (PC12) cells. The drug also inhibited nicotinic acetylcholine receptor (nAChR) channel currents but not inward currents evoked by extracellular ATP. Depolarization-induced intracellular Ca2+ transients were almost completely inhibited in growth cones and cell bodies by CGS 9343B. Our results suggest actions of CGS 9343B on ion fluxes unrelated to calmodulin inhibition.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Neuhaus R,Reber BF

doi

10.1016/0922-4106(92)90182-u

keywords:

subject

Has Abstract

pub_date

1992-06-05 00:00:00

pages

183-5

issue

2

eissn

0014-2999

issn

1879-0712

journal_volume

226

pub_type

杂志文章

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