Abstract：
:The main goal of this project was to study the effect of amiodarone upon ventricular fibrillation and defibrillation thresholds (VFT and VDT) in the canine heart under normal and ischemic conditions. Both parameters were assessed in 11 dogs, each experiment consisting of three consecutive phases: (a) control, which resulted in VFT = 27.9 (S.D. = 15.5) and VDT = 43.9 (S.D. = 4.5); (b) drug, with VFT = 63.5 (S.D. = 32.8) and VDT = 57.8 (S.D. = 11.3), and (c) coronary occlusion, with VFT = 44.7 (S.D. = 21.6) and VDT = 57.1 (S.D. = 11.0). These values are overall means scaled to ventricular weight (microA/g for VFT and mA/g for VDT). Both VFT and VDT in (b) and (c) were, on the average, greater than in (a) and these differences were statistically significant (P less than 0.01, paired t-test). The animals were kept normothermic (37.3 degrees C, S.D. = 0.6) within normal values for the acid-base state. We concluded that amiodarone increased the VFT significantly. Similarly, it increased VDT. However, although the latter change was statistically significant, we believe it would not be important from a physiological or clinical point of view.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Arredondo MT,Guillen SG,Quinteiro RAdoi
10.1016/0014-2999(86)90079-8subject
Has Abstractpub_date
1986-06-05 00:00:00pages
23-8issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(86)90079-8journal_volume
125pub_type
杂志文章abstract：:In the present work we evaluated the anticonvulsant effects of two novel antagonists of the glycine co-agonist site (glycineB receptor) within the N-methyl-D-aspartate (NMDA) receptor complex, MRZ 2/576 (a tricyclic pyrido-phtalazin dione derivative) and L-701,324 (7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)quinoline)...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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doi：10.1016/0014-2999(76)90156-4
更新日期：1976-10-01 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and in the induction of corticosteroid (CS) insensitivity. Chronic ozone exposure leads to a model of COPD with lung inflammation and emphysema. Mitogen-activated protein kinase phosphatase-1 (MKP-1) may underl...
journal_title：European journal of pharmacology
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abstract：:Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimu...
journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(88)90537-7
更新日期：1988-07-14 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90602-9
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abstract：:The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(87)90567-x
更新日期：1987-09-23 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1975-08-01 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1997-05-12 00:00:00
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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abstract：:An enhanced vasoconstrictor activity of cutaneous arteries participates in the reduction of skin blood flow induced by cooling stimulation. Raynaud's phenomenon, which is characterized by intense cooling-induced constriction of cutaneous arteries, is more common in women during the period from menarche to menopause. W...
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journal_title：European journal of pharmacology
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doi：10.1016/j.ejphar.2008.02.002
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pub_type： 杂志文章
doi：10.1016/s0014-2999(03)02016-8
更新日期：2003-08-22 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2008.06.077
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(85)90146-3
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1998-08-21 00:00:00
abstract：:The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a d...
journal_title：European journal of pharmacology
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abstract：:We investigated the role of K(ATP) channel on acute urinary retention (AUR) induced bladder dysfunction. Eight-week-old female Sprague-Dawley rats were divided into seven groups: a sham-operated control group, an AUR group, and five AUR groups treated with: two different K(ATP) channel openers namely nicorandil (3 or ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：2010-06-10 00:00:00
abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(00)00575-6
更新日期：2000-09-22 00:00:00
