Kainic acid stimulates GABA release from a subpopulation of cerebellar astrocytes.

Abstract:

:The effect of acute exposure to micromolar concentrations of kainic acid was studied in rat cerebellar astroglial cultures consisting of two antigenically and functionally distinct subpopulations of astrocytes. Kainate (20-100 microM) released [3H]GABA preaccumulated by A2B5-positive stellate astrocytes in a concentration-, Na+- and Ca2+-dependent way, and did not interfere with [3H]GABA transport. We hypothesize that kainate depolarizes this class of cells by activating cationic channels and that this results in an imbalance of GABAergic transmission.

journal_name

Eur J Pharmacol

authors

Gallo V,Suergiu R,Levi G

doi

10.1016/0014-2999(86)90624-2

subject

Has Abstract

pub_date

1986-12-16 00:00:00

pages

319-22

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(86)90624-2

journal_volume

132

pub_type

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