Differing actions of beta-(2-thienyl)-gamma-aminobutyric acid in central and peripheral preparations.

abstract：:In our previous study, it was found that linoleoyl ethanolamide (LE) is present in sake lees, which are produced as a byproduct during the making of Japanese sake. LE is a fatty acid ethanolamide, which have been demonstrated to exert a variety of biological functions, and in this study, the anti-inflammatory effects ...

journal_title：European journal of pharmacology

authors： Ishida T,Nishiumi S,Tanahashi T,Yamasaki A,Yamazaki A,Akashi T,Miki I,Kondo Y,Inoue J,Kawauchi S,Azuma T,Yoshida M,Mizuno S

更新日期：2013-01-15 00:00:00

abstract：:Adenosine monophosphate activated kinase (AMPK), a regulator of cellular metabolism, has been shown to relax arterial smooth muscle via endothelium-dependent and independent mechanisms. We have examined the role of AMPK in different smooth muscles using the activating compound, 5-amino-4-imidazolecarboxamide riboside-...

journal_title：European journal of pharmacology

authors： Davis B,Rahman A,Arner A

更新日期：2012-11-15 00:00:00

abstract：:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic...

journal_title：European journal of pharmacology

authors： Eaton MJ,Lookingland KJ,Moore KE

更新日期：1996-03-28 00:00:00

abstract：:We have previously found that the induction of long-term potentiation in the synaptic pathway from the basolateral amygdala to the dentate gyrus (BLA-DG LTP) is regulated by L-type Ca(2+) channels, dopamine D(2) receptors and GABAergic inhibition. In the present study, we investigated possible relations among the thre...

journal_title：European journal of pharmacology

authors： Abe K,Fujimoto T,Niikura Y,Akaishi T,Misawa M

更新日期：2009-03-15 00:00:00

abstract：:Recently, stable gastric pentadecapeptide BPC 157 reversed the high MDA- and NO-tissue values to the healthy levels. Thereby, BPC 157 therapy cured rats with bile duct ligation (BDL) (sacrifice at 2, 4, 6, 8 week). BPC 157-medication (10 μg/kg, 10 ng/kg) was continuously in drinking water (0.16 μg/ml, 0.16 ng/ml, 12 m...

journal_title：European journal of pharmacology

authors： Sever AZ,Sever M,Vidovic T,Lojo N,Kolenc D,Vuletic LB,Drmic D,Kokot A,Zoricic I,Coric M,Vlainic J,Poljak L,Seiwerth S,Sikiric P

更新日期：2019-03-15 00:00:00

abstract：:The present study investigated whether there is any difference between the effects of benzodiazepine and non-benzodiazepine anxiolytics on maternal aggression in lactating mice, using an ethological technique. We used SM-3997, a 5-HT1A receptor ligand, as a non-benzodiazepine anxiolytic. Behavior towards an intruder m...

journal_title：European journal of pharmacology

authors： Yoshimura H,Ogawa N

更新日期：1991-07-23 00:00:00

abstract：:Compared with sham-operated guinea pigs, chronic heart failure produced by aortic constriction resulted in a 79% increase in alpha 1-adrenoceptor density as measured by [3H]prazosin binding (73 +/- 15 vs. 131 +/- 20 fmol/mg protein, P < 0.05); beta-adrenoceptor number, measured by (-)-[3H]dihydroalprenolol binding, in...

journal_title：European journal of pharmacology

authors： Karliner JS,Barnes P,Brown M,Dollery C

更新日期：1980-10-03 00:00:00

abstract：:Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor ...

journal_title：European journal of pharmacology

authors： Nambi P,Pullen M,Wu HL,Brooks DP

更新日期：1991-03-19 00:00:00

abstract：:Acute leukemia is a malignant clonal hematopoietic stem cell disease. In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited t...

journal_title：European journal of pharmacology

authors： Wang Y,Zhang J,Wang Q,Zhang T,Yang Y,Yi Y,Gao G,Dong H,Zhu H,Li Y,Lin H,Tang H,Chen X

更新日期：2013-10-15 00:00:00

abstract：:Three naturally occurring peptides, pGlu-Glu-Pro amide, pGlu-Phe-Pro amide and pGlu-Gln-Pro amide, with similar structures to thyrotropin releasing hormone (TRH) have recently been identified but no studies of their in vivo activities have been reported previously. We describe here the ability of pGlu-Phe-Pro amide an...

journal_title：European journal of pharmacology

authors： Cremades A,Peñafiel R,Rausell V,Del Rio-Garcia J,Smyth DG

更新日期：1998-09-25 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. PPARgamma regulates several metabolic pathways by binding to sequence-specific PPAR response elements in the promoter region of target genes, including lipid bi...

journal_title：European journal of pharmacology

authors： Belvisi MG,Hele DJ,Birrell MA

更新日期：2006-03-08 00:00:00

abstract：:Statin therapy is used ubiquitously to reduce cholesterol levels, and recent studies have revealed statin use may be associated with a reduced risk of inflammatory bowel disease (IBD). A comprehensive assessment of the literature was performed to investigate whether statin use may influence the risk of new-onset IBD. ...

journal_title：European journal of pharmacology

authors： Bhagavathula AS,Clark C,Rahmani J

更新日期：2021-01-15 00:00:00

abstract：:The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying highe...

journal_title：European journal of pharmacology

authors： Mandal TK,Das NS

更新日期：2009-04-01 00:00:00

abstract：:The origin of the thrombocytopenia and leucopenia induced by protamine-heparin complexes is unknown. We studied the biochemical and cellular effects of protamine (6 mg x kg-1, i.v.) injected after heparin (5 mg x kg-1, i.v.) in New Zealand rabbits. After protamine injection (0.5 min) increases in blood platelet-activa...

journal_title：European journal of pharmacology

authors： Aïssa J,Nathan N,Arnoux B,Benveniste J

更新日期：1996-04-29 00:00:00

abstract：:The alpha 1-adrenoceptors present in the liver of rhesus monkeys was characterized using [3H]prazosin. This radioligand binds to monkey liver membranes with high affinity (KD 0.33 nM) to a moderately abundant number of sites (97 fmol/mg of protein). These sites were characterized pharmacologically, by binding competit...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Romero-Avila MT,González-Espinosa C

更新日期：1996-09-12 00:00:00

abstract：:Field stimulation of isolated rat vas deferens preparations caused a twitch contraction followed by a slower phasic contraction. Exogenously applied ATP and noradrenaline caused rapid contractions and slowly developing contractions respectively. Pretreatment with phentolamine antagonised the phasic response to stimula...

journal_title：European journal of pharmacology

authors： Satchell D

更新日期：1986-12-16 00:00:00

abstract：:In conscious rats, intracerebroventricular (i.c.v.) treatment with the GABA agonist muscimol (1-100 ng) suppressed the pressor responses to ANG II (100 ng i.c.v.) in a dose-dependent and reversible fashion. Treatment i.c.v. with GABA (1-500 micrograms) produced a similar but shorter inhibition. Inhibition of endogenou...

journal_title：European journal of pharmacology

authors： Unger T,Bles F,Ganten D,Lang RE,Rettig R,Schwab NA

更新日期：1983-05-20 00:00:00

abstract：:This report describes the molecular pharmacological properties of LR-B/081 (methyl 2-[[4-butyl-2-methyl-6-oxo-5-[[2'-(1H-tetrazol-5- yl) [1,1'-biphenyl]-4-yl]methyl]-1 (6H)-pyrimidinyl]methyl]- 3-thiophenecarboxilate), a novel non-peptide angiotensin II receptor antagonist. This compound potently displaced [3H]angiote...

journal_title：European journal of pharmacology

authors： Renzetti AR,Criscuoli M,Salimbeni A,Subissi A

更新日期：1995-07-18 00:00:00

abstract：:Certain enkephalin analogues, including those which contain the conformationally restricted amino acid E-(2R,3S)-cyclopropylphenylalanine [2R,3S)-delta E Phe), have been shown to have high affinity for brain delta opioid receptors but are much less active in mouse vas deferens bioassays. To investigate whether there a...

journal_title：European journal of pharmacology

authors： Vaughn LK,Wire WS,Davis P,Shimohigashi Y,Toth G,Knapp RJ,Hruby VJ,Burks TF,Yamamura HI

更新日期：1990-02-20 00:00:00

abstract：:The alpha 1-adrenoceptor agonist, SDZ NVI-085 ((-)-(4aR,10aR)-3,4,4a,5,10,10a-hexahydro-6-methoxy-4- methyl-9-(methylthio)-2H-naphth[2,3-b]-1,4-oxazine.HCl; 1 mg/kg i.p.), decreased body temperature of guinea-pigs. Two 5-HT1D receptor antagonists, GR127935 (N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(...

journal_title：European journal of pharmacology

authors： Kalkman HO,Neumann V

更新日期：1995-10-24 00:00:00

abstract：:Effects of (2RS, 3SR)-2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8, 8-pentamethyl-6H-furo-[2,3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic drug with beta-adrenoceptor blocking property and antiarrhythmic activity, on the action potentials of isolated papillary muscles and the membrane currents of single ve...

journal_title：European journal of pharmacology

authors： Uemura H,Sakamoto N,Nakaya H

更新日期：1999-11-03 00:00:00

abstract：:Neurokinins activate a series of tetrodotoxin (TTX)-insensitive rhythmic contractions of the rat isolated ureter. Field stimulation or capsaicin (1-3 microM) produced a transient inhibition of neurokinin-activated ureteral motility in preparations from control but not from capsaicin-pretreated (50 mg/kg s.c.) rats. Th...

journal_title：European journal of pharmacology

authors： Maggi CA,Santicioli P,Giuliani S,Abelli L,Meli A

更新日期：1986-07-31 00:00:00

abstract：:To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. E...

journal_title：European journal of pharmacology

authors： He Y,Zeng H,Yu Y,Zhang J,Liu Q,Yang B

更新日期：2017-11-15 00:00:00

abstract：:Rat pheochromocytoma PC12W cell membranes have previously been shown to exclusively contain the AT2 receptor subtype. The present study extended these binding data and explored the functional expression of these binding sites. Our binding competition studies show a potency series of Ang II = Ang III greater than saral...

journal_title：European journal of pharmacology

authors： Leung KH,Roscoe WA,Smith RD,Timmermans PB,Chiu AT

更新日期：1992-09-01 00:00:00

abstract：:Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible appl...

journal_title：European journal of pharmacology

authors： Hattori R,Inoue R,Sase K,Eizawa H,Kosuga K,Aoyama T,Masayasu H,Kawai C,Sasayama S,Yui Y

更新日期：1994-04-15 00:00:00

abstract：:The effects of chronic neuroleptic treatment on the concentrations of homovanillic acid (HVA) and 3,4-dihydroxy-phenylacetic acid (DOPAC) in the rat substantia nigra (SN) and corpus striatum (CS) were determined. Acute haloperidol and alpha-flupenthixol increased HVA and DOPAC in the CS but after chronic treatment no ...

journal_title：European journal of pharmacology

authors： Nicolaou NM

更新日期：1980-06-13 00:00:00

abstract：:IRL1620, a specific endothelin ETB receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range studied. Repeated administration of IRL1620 induced tachyphylaxis only of the contractile component, wh...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Paiva AC

更新日期：1995-10-24 00:00:00

abstract：:The in vitro biological characterisation of the first potent and selective non-peptide neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl] cylopentyl] acetyl]-N-[2-[1,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3H-1,2, 4-triazol-4-yl]et...

journal_title：European journal of pharmacology

authors： Doods H,Gaida W,Wieland HA,Dollinger H,Schnorrenberg G,Esser F,Engel W,Eberlein W,Rudolf K

更新日期：1999-11-19 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) is a critical regulator of many genes involved in the pathogenesis of bacterial meningitis. Recently, activation of NF-kappaB was shown to be a key event in the inflammatory host response and the development of intracranial complications during experimental pneumococcal meningitis. Si...

journal_title：European journal of pharmacology

authors： Kastenbauer S,Koedel U,Weih F,Ziegler-Heitbrock L,Pfister HW

更新日期：2004-09-13 00:00:00

abstract：:We investigated the acute and chronic effects of alpha 2-adrenoceptor and muscarinic receptor agonists on dihydropyridine-sensitive voltage-dependent Ca2+ channels in spinal cord-dorsal root ganglion cocultures. Clonidine and oxotremorine inhibited the voltage-dependent Ca2+ influx (42 +/- 2% and 35 +/- 6% with 100 mi...

journal_title：European journal of pharmacology

authors： Nah SY,Attali B,Vogel Z

更新日期：1993-01-04 00:00:00