Preferential inhibition of inducible nitric oxide synthase by ebselen.

abstract：:The cocaine analog 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (RTI-55 or beta CIT) has a higher affinity for the dopamine transporter and may be potentially useful in interfering with cocaine's actions in brain. However, imaging studies have demonstrated displacement of tracer doses of [123I]RTI-...

journal_title：European journal of pharmacology

authors： Gatley SJ,Volkow ND,Chen R,Fowler JS,Carroll FI,Kuhar MJ

更新日期：1996-01-25 00:00:00

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:Drugs known to interact with Na+ channels were compared as antagonists of Ca2+-induced contractions of K+-depolarized taenia preparations from guinea-pig caecum. Tetracaine (apparent pA2 5.3 +/- 0.2), quinidine (5.2 +/- 0.1) quinine (5.1 +/- 0.1), d-propranolol (4.7 +/- 0.1), 1-propranolol (4.7 +/- 0.1), lignocaine (4...

journal_title：European journal of pharmacology

authors： Spedding M,Berg C

更新日期：1985-01-22 00:00:00

abstract：:The effects of ketamine and barbiturates (pentobarbital, thiopental, methohexital) were studied in an isolated rabbit Langendorff preparation. All agents tested depressed contractility. Ketamine, as well as the lipophilic barbiturates (thiopental, methohexital), caused a relatively greater depression at higher pacing ...

journal_title：European journal of pharmacology

authors： Davies AE,McCans JL

更新日期：1979-10-26 00:00:00

abstract：:Nanog is a major transcription factor related to cellular multipotency that plays important roles in the development of tumor cells, drug resistance, migration, and stemness; indicating its great potential as a therapeutic target for various malignancies including colorectal cancer (CRC). Therefore, this study was aim...

journal_title：European journal of pharmacology

authors： Khosravi N,Shahgoli VK,Amini M,Safaei S,Mokhtarzadeh A,Mansoori B,Derakhshani A,Baghbanzadeh A,Baradaran B

更新日期：2021-01-16 00:00:00

abstract：:The vascular effects of bradykinin were studied in rat perfused mesenteric vascular beds with active tone. Bolus injections of bradykinin (1-1000 pmol) but not des-Arg(9)-bradykinin (bradykinin B(1) receptor agonist) induced triphasic vascular responses: the initial sharp vasodilation followed by transient vasoconstri...

journal_title：European journal of pharmacology

authors： Nawa H,Kawasaki H,Nakatsuma A,Isobe S,Kurosaki Y

更新日期：2001-12-14 00:00:00

abstract：:Morphine 6-glucuronide, a major metabolite of morphine with potent analgesic actions, is a potent inhibitor of intestinal motility when administered to rats by the intracerebroventricular (i.c.v.) route. Morphine 6-glucuronide was 62-fold more active than morphine in inhibiting gastrointestinal transit, whereas it was...

journal_title：European journal of pharmacology

authors： Massi P,Giagnoni G,Basilico L,Gori E,Rubino T,Parolaro D

更新日期：1994-03-03 00:00:00

abstract：:Effects of nicotine, and nicotine+vitamin E on glutathione reductase (Glutathione: NADP(+) oxidoreductase, EC 1.8.1.7) activity in the muscle, heart, lungs, testicles, kidney, stomach, brain and liver tissues were investigated in vivo and also in vitro. The groups were: nicotine [0.5 mg/kg/day, intraperitoneal (i.p.)]...

journal_title：European journal of pharmacology

authors： Erat M,Ciftci M,Gumustekin K,Gul M

更新日期：2007-01-12 00:00:00

abstract：:Several recent reports have demonstrated a role for selective cannabinoid CB2 receptor agonists in pain modulation, showing both analgesic and antihyperalgesic activities. While the mechanism of action is poorly understood, it has been postulated that these effects may be indirect, involving release of endogenous opio...

journal_title：European journal of pharmacology

authors： Whiteside GT,Gottshall SL,Boulet JM,Chaffer SM,Harrison JE,Pearson MS,Turchin PI,Mark L,Garrison AE,Valenzano KJ

更新日期：2005-12-28 00:00:00

abstract：:Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis w...

journal_title：European journal of pharmacology

authors： Lee HZ,Hsu SL,Liu MC,Wu CH

更新日期：2001-11-23 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:[14C]Guanidinium ion influx into Na+ channel preparations from mouse and rat cerebral cortex (purified synaptosomes, and synaptoneurosomes) was characterized and its properties were compared with those for 22Na+ influx. Tetrodotoxin-sensitive influx of [14C]guanidinium ion was stimulated by aconitine, veratridine, and...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1990-01-23 00:00:00

abstract：:The role of the glutamate 'metabotropic' receptor was investigated in an experimental model of focal ischaemia-induced neurodegeneration. The metabotropic agonist, trans-1-amino cyclopentane-1,3-dicarboxylic acid (t-ACPD, 20 mg/kg i.p.), was administered to mice immediately after middle cerebral artery occlusion (MCAO...

journal_title：European journal of pharmacology

authors： Chiamulera C,Albertini P,Valerio E,Reggiani A

更新日期：1992-06-05 00:00:00

abstract：:Lipopolysaccharide (LPS) administration in rats induces a characteristic syndrome termed 'sickness behavior', including profound changes on locomotor activity and circulating stress and inflammatory mediators. The aim of the present investigation was to evaluate whether the behavioral and the peripheral biomarker resp...

journal_title：European journal of pharmacology

authors： Bison S,Razzoli M,Arban R,Michielin F,Bertani S,Carboni L

更新日期：2011-07-01 00:00:00

abstract：UNLABELLED:The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar rats were used after the induction of a chronic acetic acid ulcer. The animals were treated orally for 8 and 15 days, twice daily,...

journal_title：European journal of pharmacology

authors： Berenguer B,Alarcón de la Lastra C,Moreno FJ,Martín MJ

更新日期：2002-05-03 00:00:00

abstract：:The effects of chronic neuroleptic treatment on the concentrations of homovanillic acid (HVA) and 3,4-dihydroxy-phenylacetic acid (DOPAC) in the rat substantia nigra (SN) and corpus striatum (CS) were determined. Acute haloperidol and alpha-flupenthixol increased HVA and DOPAC in the CS but after chronic treatment no ...

journal_title：European journal of pharmacology

authors： Nicolaou NM

更新日期：1980-06-13 00:00:00

abstract：:Neurotensin induced the release of histamine from both purified and non-purified rat peritoneal mast cells by a non-cytotoxic mechanism. It was effective at a concentration as low as 10(-8) M. The dose-response curve for the neurotensin effect was triphasic: and initial gentle rise, a plateau (2.5 X 10(-7) -2.5 X 10(-...

journal_title：European journal of pharmacology

authors： Kurose M,Saeki K

更新日期：1981-12-03 00:00:00

abstract：:Hydrogen sulfide (H2S) is a gasotransmitter synthesized in peripheral tissues by the enzyme cystathionine gamma-lyase (CSE). This gas has been documented to be involved in a wide variety of processes including inflammation and nociception. The aim of the present study was to investigate the role of the peripheral H2S ...

journal_title：European journal of pharmacology

authors： Donatti AF,Araujo RM,Soriano RN,Azevedo LU,Leite-Panissi CA,Branco LG

更新日期：2014-09-05 00:00:00

abstract：:We investigated the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on macromolecule extravasation in the microcirculation of awake hamsters by computer-assisted image analysis of the distribution of FITC (fluorescein isothiocyanate)-dextran fluorescence in dorsal fold skin preparations. This analy...

journal_title：European journal of pharmacology

authors： Gimeno G,Carpentier PH,Desquand-Billiald S,Hanf R,Finet M

更新日期：1998-04-10 00:00:00

abstract：:The interference of azelastine with pleurisy induced by antigen was investigated in actively sensitized rats. The antigenic challenge (ovalbumin, 12 micrograms/cavity) caused early plasma leakage, which peaked within 4 h, accompanied by intense neutrophil infiltration. Pleural exudate decayed 24 h after antigen provoc...

journal_title：European journal of pharmacology

authors： Lima MC,Martins MA,Perez SA,Silva PM,Cordeiro RS,Vargaftig BB

更新日期：1991-05-17 00:00:00

abstract：:Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected ...

journal_title：European journal of pharmacology

authors： Lee YW,Kim DH,Jeon SJ,Park SJ,Kim JM,Jung JM,Lee HE,Bae SG,Oh HK,Son KH,Ryu JH

更新日期：2013-03-15 00:00:00

abstract：:The effect of intracutaneous adrenaline and noradrenaline (5 X 10(-12) and 5 X 10(-11) mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly pot...

journal_title：European journal of pharmacology

authors： O'Duffy G,Chahl LA

更新日期：1979-08-15 00:00:00

abstract：:The i.c.v. administration of 0.5 microgram pertussis toxin to mice led to a non-competitive reduction (approximately 60 to 70%) of the supraspinal analgesia evoked by i.c.v. injection of ED90 doses of [D-Ala2,N-MePhe4,Gly-ol5]enkephalin, [D-Ala2,N-MePhe4,Met-(O)5-ol]enkephalin, [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1988-08-02 00:00:00

abstract：:It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies have shown a clear involvement of GABA (gamma-amino butyr...

journal_title：European journal of pharmacology

authors： Kommalage M,Höglund AU

更新日期：2005-11-21 00:00:00

abstract：:We have characterized the tachykinin NK(2) receptor-mediated contraction and vectorial ion transport responses in the muscularis mucosae and mucosa of the rat isolated distal colon, respectively. The tachykinin NK(2) receptor-selective antagonist nepadutant (c([(beta-D-GlcNAc)Asn-Asp-Trp-Phe-Dpr-Leu]c(2beta-5beta))) p...

journal_title：European journal of pharmacology

authors： Patacchini R,Cox HM,Ståhl S,Tough IR,Maggi CA

更新日期：2001-03-01 00:00:00

abstract：:Bupropion is a weakly potent central nervous system (CNS) stimulant that is marketed both as an antidepressant and as an anti-smoking aid. The mechanism(s) by which it produces its effects is not well understood. In the present study, the effect of bupropion was examined in rats trained to discriminate the stimulus ef...

journal_title：European journal of pharmacology

authors： Young R,Glennon RA

更新日期：2002-05-17 00:00:00

abstract：:We investigated the pharmacological effects of a new anti-hyperglycemic agent, JTT-608 [trans-4-(4-methylcyclohexyl)-4-oxobutyric acid], in normal and neonatally streptozotocin-treated rats. In normal rats, JTT-608 improved glucose tolerance at 3-30 mg/kg, doses that did not cause a decrease in fasting blood glucose l...

journal_title：European journal of pharmacology

authors： Ohta T,Furukawa N,Yonemori F,Wakitani K

更新日期：1999-02-12 00:00:00

abstract：:Previously, sex differences have been observed in the behavioral effects of acute and chronic cocaine administration. In the present experiment, male and female rats were trained to discriminate intraperitoneal injections of 10.0 mg/kg cocaine from its vehicle. It was hypothesized that the subjective effects of cocain...

journal_title：European journal of pharmacology

authors： Anderson KG,van Haaren F

更新日期：1999-10-08 00:00:00

abstract：:Hydrolysis of ([3H]Leu5)-enkephalin into the tripeptide [3H]Tyr-Gly-Gly can be detected using particulate fractions from a variety of peripheral organs. In some tissues, e.g. exocrine and endocrine glands, this dipeptidyl carboxypeptidase ("enkephalinase") activity is even higher than in brain. ...

journal_title：European journal of pharmacology

authors： Llorens C,Schwartz JC

更新日期：1981-01-05 00:00:00

abstract：:Substance P stimulates substance P receptors but also inhibits ion conductance through nicotinic acetylcholine receptors. Substance P analogs, classified as agonists or antagonists based on their actions on smooth muscle, were tested to determine if they also could act at nicotinic receptors on the pheochromocytoma, P...

journal_title：European journal of pharmacology

authors： Eardley D,McGee R Jr

更新日期：1985-08-07 00:00:00