Abstract:
:The present study examined the adverse effects of delta-9-tetrahydrocannabinol (i.p injection in albino mice) on free radical damage of testicular lipids (lipid peroxidation) at low doses and the role of antioxidant enzymes defense system at high dose and particularly at the withdrawal of the drug after applying higher dose (recovery dose). At lower doses (total doses ranging from 6 mg to 28 mg), there was a significant increase of lipid peroxidation and decrease in testicular lipid content. But the effects were slightly lowered at high dose (total dose 70 mg) and at the withdrawal of the drug (recovery dose). Similarly, marked decrease of antioxidant enzyme systems (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione content were noticed at low doses. But the effects were slightly higher at high dose and at the withdrawal of the drug. Similarly, low-dose treatments caused significant shrinkage of tubular diameter and detrimental changes in seminiferous epithelium of testis resulting in lowered plasma testosterone and pituitary gonadotropins (follicular stimulating and luteinizing hormone levels. But at high dose and particularly at withdrawal of the drug, regression of seminiferous tubules and recovery of various germ cell layers of testes through the revival of testosterone hormone and pituitary gonadotropins were observed.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Mandal TK,Das NSdoi
10.1016/j.ejphar.2009.01.025subject
Has Abstractpub_date
2009-04-01 00:00:00pages
178-87issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(09)00076-4journal_volume
607pub_type
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